Abstract: A rotor for a reluctance machine and a method of producing a rotor for a reluctance machine is provided. The rotor is formed as a soft magnetic element which is cylindrical in shape. The soft magnetic element has recesses for forming flux barriers, one or more flux barriers being at least partially filled with a filler material, and the filler material of said flux barriers extending up to the rotor periphery and forming part of the rotor periphery.

Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).

Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).

Abstract: A rotor for a reluctance machine and a method of producing a rotor for a reluctance machine is provided. The rotor is formed as a soft magnetic element which is cylindrical in shape. The soft magnetic element has recesses for forming flux barriers, one or more flux barriers being at least partially filled with a filler material, and the filler material of said flux barriers extending up to the rotor periphery and forming part of the rotor periphery.

Abstract: A method for producing a rotor for a reluctance machine, in particular for a synchronous reluctance machine, and a rotor produced by the method, are provided. The laminated rotor core is produced by punching and stacking two or more adjacent laminations of the core. The adjacent laminations are held together by at least one connection point created during the punch stacking, the at least one connection point simultaneously forming a flux barrier of the rotor. The rotor comprises a laminated core, which is stacked from at least two lamination sheets, with the at least two adjacent lamination cuts being connected to each other by at least one connection point forming at least one flux barrier of the rotor.