Abstract: Provided herein are precise gene replacement methods and transgenic non-human animals produced by such methods, in which an endogenous non-human animal gene of interest is precisely replaced with a human syntenic gene. The resulting genetically modified non-human animals are useful for evaluating molecular impact of pathogenic mutations within the context of the human genomic sequence in which they occur in patients and for screening for potential therapeutic agents.

Abstract: A method of providing at least one data carrier for a computer system includes downloading at least one image of a data carrier from a predetermined network source by a service processor of the computer system, the service processor being operable independently of a main processor and an operating system of the computer system; storing, by the service processor, the at least one downloaded image in a non-volatile bulk memory; incorporating, by the service processor, the at least one stored image as active data carrier of a virtual memory drive; and emulating a standard interface that accesses the virtual memory drive such that an operating system can access the active data carrier without manufacturer-specific driver software.

Abstract: A method of providing at least one data carrier for a computer system includes downloading at least one image of a data carrier from a predetermined network source by a service processor of the computer system, the service processor being operable independently of a main processor and an operating system of the computer system; storing, by the service processor, the at least one downloaded image in a non-volatile bulk memory; incorporating, by the service processor, the at least one stored image as active data carrier of a virtual memory drive; and emulating a standard interface that accesses the virtual memory drive such that an operating system can access the active data carrier without manufacturer-specific driver software.

Abstract: The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms.

Abstract: An uncoupling element is proposed for uncoupling vibrations in an exhaust gas conduit of an internal combustion engine, having a screw thread-shaped or annular waved, metal corrugated hose, which is inserted between a first conduit element arranged upstream and a second conduit element arranged downstream.