Patents by Inventor Michael Kornacker

Michael Kornacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ICOS ligand variant immunomodulatory proteins and uses thereof
    Patent number: 12110339
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: October 8, 2024
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20240002466
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: March 10, 2023
    Publication date: January 4, 2024
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • CD112 variant immunomodulatory proteins and uses thereof
    Patent number: 11834490
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD112 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 5, 2023
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer, Dan Ardourel, Joseph L. Kuijper
  • PD-L2 variant immunomodulatory proteins and uses thereof
    Patent number: 11732022
    Abstract: Provided herein are immunomodulatory proteins comprising variant PD-L2 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: August 22, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • VARIANT ICOS LIGAND IMMUNOMODULATORY PROTEINS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20230235012
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: February 21, 2023
    Publication date: July 27, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Michael Kornacker, Ryan Swanson
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11639375
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 2, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • Variant ICOS ligand immunomodulatory proteins and related compositions and methods
    Patent number: 11613566
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: March 28, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Michael Kornacker, Ryan Swanson
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11498967
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: November 15, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11479609
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: October 25, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD155 variant immunomodulatory proteins and uses thereof
    Patent number: 11471488
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD155 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: October 18, 2022
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11359022
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: June 14, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • Immunomodulatory proteins with tunable affinities
    Patent number: 11319359
    Abstract: Provided are immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 3, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11230588
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: January 25, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117949
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117950
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117948
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11096988
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 24, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11078282
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 3, 2021
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker
  • ICOS ligand variant immunomodulatory proteins and uses thereof
    Patent number: 10882914
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: January 5, 2021
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney
    Publication number: 20080014593
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 31, 2007
    Publication date: January 17, 2008
    Inventors: Lauren Barber, Angela Cacace, John Feder, Thomas Nelson, Chandra Ramanathan, Rolf-Peter Ryseck, Michael Neubauer, Michael Kornacker