Patents by Inventor Michael Kotlikoff

Michael Kotlikoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional nucleic acid ligands to fluorescent proteins
    Patent number: 8445655
    Abstract: The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: May 21, 2013
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Michael Kotlikoff, John T. Lis, Bo Shui, Hua Shi
  • FUNCTIONAL NUCLEIC ACID LIGANDS TO FLUORESCENT PROTEINS
    Publication number: 20090197271
    Abstract: The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed.
    Type: Application
    Filed: June 18, 2007
    Publication date: August 6, 2009
    Applicant: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Michael Kotlikoff, Hua Shi, Bo Shui, John T. Lis
  • Vectors for conditional gene inactivation
    Patent number: 7449179
    Abstract: A method of preparing gene trapping libraries, and gene targeted cells for conditional inactivation of genes, is provided. The invention provides a vector having a mutational element cassette and a gene trap cassette, each cassette having site-specific recombination sequences.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: November 11, 2008
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Hong-Bo Xin, Michael Kotlikoff
  • Vectors for conditional gene inactivation
    Publication number: 20040077089
    Abstract: A method of preparing gene trapping libraries, and gene targeted cells for conditional inactivation of genes, is provided.
    Type: Application
    Filed: November 6, 2003
    Publication date: April 22, 2004
    Inventors: Hong-Bo Xin, Michael Kotlikoff