Patents by Inventor Michael Kraus

Michael Kraus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for analyzing particle-enhanced agglutination reactions in centrifugal analyzers by determining the brightening of turbidity
    Patent number: 5571728
    Abstract: The invention relates to a method for determining analytes, in which a sample of a biological material which possibly contains this analyte is incubated with at least one binding partner which is specific for the analyte and which is immobilized on a particulate carrier material, and the change in turbidity brought about by the analyte is determined.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: November 5, 1996
    Assignee: Behringwerke Aktiengesellschaft
    Inventor: Michael Kraus
  • Method for the determination of antibodies against lipocortins
    Patent number: 5316915
    Abstract: The invention relates to a method for the determination of antibodies against lipocortins (annexins) in a body fluid of a species, using proteins from the lipocortin family bound to a solid phase and using a labeled bioaffinity binding partner which is directed against single classes or a plurality of classes of immunoglobulins of this species.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: May 31, 1994
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Michael Kraus, Jurgen Romisch
  • Method of producing thrombin from factor II using calcium ions for the conversion on an anion exchanger
    Patent number: 5143838
    Abstract: A method of producing thrombin from Factor II (prothrombin) comprising the steps of:a) applying a solution of citrated plasma or citrated plasma fraction containing Factor II onto an equilibrated anion exchanger to bind Factor II thereto;b) applying a solution containing calcium ions to the exchanger to convert the Factor II to thrombin, andc) selectively eluting the thrombin from the carrier.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: September 1, 1992
    Assignee: Biotest Pharma GmbH
    Inventors: Michael Kraus, Wolfgang Moller
  • Method of enrichment of coagulation factors II, VII, IX and X
    Patent number: 5071961
    Abstract: A method of enrichment of coagulation Factors II, VII, IX and X in preparations obtained from plasma, plasma fractions, or other liquids containing the factors, by adsorbing the factor or factors onto a polymeric matrix that carries an .alpha.-hydroxylamine group, and eluting the factors. When the chromatography conditions are appropriate, it is also easy to prepare a highly concentrated Factor IX preparation with a purity of more than 10 U per mg of protein.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: December 10, 1991
    Assignee: Biotest Pharma GmbH
    Inventors: Michael Kraus, Wolfgang Moller, Bertram Eichentopf
  • Method of isolating blood-clotting factor IX
    Patent number: 5061789
    Abstract: A method of isolating blood-clotting Factor IX. A solution containing the Factor IX is adsorbed onto an adsorbent carrying .alpha.-hydroxylamine groups, and the factor is eluted. The Factor IX from the eluate is adsorbed onto a matrix carrying sulfated carbohydrates, with the conductivity adjusted to 13-17 mS/cm, and eluted with a salt gradient. The pure Factor IX is concentrated and freeze-dried.
    Type: Grant
    Filed: May 1, 1990
    Date of Patent: October 29, 1991
    Assignee: Biotest Pharma GmbH
    Inventors: Wolfgang Moller, Michael Kraus