Patents by Inventor Michael Kriegler

Michael Kriegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions
    Patent number: 5324655
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF. Particularly disclosed is a DNA construct in which a gene encoding tumor necrosis factor (TNF) is directly linked to DNA encoding a human .gamma.-interferon signal peptide.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: June 28, 1994
    Assignee: Cetus Oncology Corporation
    Inventors: Michael Kriegler, Carl Perez