Abstract: The present invention relates to a method of producing a peptide consisting of the amino acids 63 to 110 of dermcidin (SEQ ID NO: 3) comprising (a) culturing a host cell carrying a nucleic acid molecule encoding the peptide in an expressible form, and (b) optionally isolating the peptide from the culture. Furthermore, the invention relates to a nucleic acid molecule encoding a fusion protein comprising or consisting of (a) a peptide heterologous with regard to dermcidin protein-tag; and, C-terminally thereof (b) a peptide having the antimicrobial activity of dermcidin wherein the fusion protein contains an arginine residue located immediately N-terminally of the peptide of (b).

Abstract: The present invention relates to the use of rosmarinic acid as a sweetness enhancer, to sweetener compositions comprising a sweetener and rosmarinic acid, to methods of making the sweetener compositions and to tabletop sweetener compositions comprising rosmarinic acid. Further, the invention relates to consumables comprising a consumable product and rosmarinic acid. Preferred consumable products are water-based consumables, solid dry consumables, dairy products, dairy-derived products and dairy-alternative products.

Abstract: The present invention primarily relates to the use of trans-tert-butyl cyclohexanol as skin irritation-reducing agent as well as compositions (formulations) having a skin irritation-reducing action comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent.

Abstract: We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds.

Abstract: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of these receptors for the identification of functional ligands is also encompassed.

Abstract: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of these receptors for the identification of functional ligands is also encompassed.

Abstract: The invention relates to the use of one or more cyclic lipopeptides, such as surfactins A, B, and C and derivatives and mixtures thereof, as a taste modulator and/or sweetness enhancer for comestible compositions containing at least one natural or artificial sweetener. The comestible compositions include food, beverages, medicinal products and cosmetics and contain preferably mono-, di- or oligosaccharides as sweeteners. The invention further relates to said comestible compositions containing a cyclic lipopeptide as taste modulator.

Abstract: The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.

Abstract: The present invention relates to a cosmetic composition for the cleaning of the skin, said composition comprising or consisting of one or more compounds of formula (I) wherein represents a single bond or double bond; R1 and R2 are independently selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, linear or branched C1 to C4 alkinyl, and linear or branched C1 to C4 alkanoyl; R4 is selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, and linear or branched C1 to C4 alkinyl; and R3 and R5 are independently selected from H, OH and halogen, or R3 and R5 together are O to form an epoxid, wherein represents a single bond in case R3 and R5 together are O. Also provided are means and methods for the prevention or reduction of biofilm formation on an intracorporeal device and/or for the removal of biofilm from an intracorporeal device, wherein said biofilm comprises or consists of bacteria of the genus Propionibacterium.

Abstract: Process for modulation of a taste and/or aftertaste in foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one high intensity sweetener HIS by addition of a taste modulator comprising a salt preparation, and use of a salt preparation for taste modulation of foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one HIS.

Abstract: Process for modulation of a taste and/or aftertaste in foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one high intensity sweetener HIS by addition of a taste modulator comprising at least one polyoxyethylene sorbitan fatty acid ester which is suitable for food, and use of a at least one polyoxyethylene sorbitan fatty acid ester which is suitable for food for taste modulation of foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one HIS.

Abstract: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of said receptors for the identification of functional ligands is also encompassed.

Abstract: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of said receptors for the identification of functional ligands is also encompassed.

Abstract: Process for taste modulation of compositions of matter which comprise at least one High Intensity Sweetener HIS, which comprises adding at least two azo compounds in a total concentration of 0.1 to 30 ppm or 0.1 to 30 mg/l as taste modulators to a composition of matter which comprises at least one HIS.

Abstract: Use of at least one type of water-dispersible carotenoid nanoparticles as taste modulators in compositions of matter; process for taste modulation of compositions of matter in which at least one type of water-dispersible carotenoid nanoparticles is added to compositions of matter; and also taste modulators for compositions of matter comprising (A) at least one type of water-dispersible carotenoid nanoparticles and (B) at least one azo compound, comprising at least one azo group.

Abstract: The present invention is a fluorescent (or LED) illuminated backlight panel. Cold-cathode lamps, external electrode fluorescent lamps, thin fluorescent lamps, or LED strips are inserted into a transparent or translucent twinwall plastic sheet, similar in construction to corrugated cardboard. The lamp (or LED) spacing is easily changed in order to alter the intensity of the light emitted by the lightpanel, the number of lamps (or LEDs) used and to change the “evenness” of the light across the panel. The twinwall plastic sheet is thin, durable and lightweight, protecting the fragile lamps and providing a simple method of mounting and wiring. The plastic sheet may also be slit on one, or both sides, yielding a flexible lightpanel; graduated dots or lines may be printed onto the surface of the plastic sheet or translucent materials may be used on the surface of the plastic sheet to assist in making the intensity of the light across the surface of the sheet more even.

Abstract: The invention relates to the use of one or more oligopeptide/s, preferably a tripeptide such as aladapcin, as a taste modulator and/or sweetness enhancer for comestible compositions preferably those containing at least one natural or artificial sweetener. The comestible compositions include food, beverages, medicinal products and cosmetics and contain preferably mono-, di- or oligosaccharides as sweeteners. The invention further relates to said comestible compositions containing an oligopeptide as taste modulator.

Abstract: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of said receptors for the identification of functional ligands is also encompassed.

Abstract: The present invention is a fluorescent (or LED) illuminated backlight panel. Cold-cathode lamps, external electrode fluorescent lamps, thin fluorescent lamps, or LED strips are inserted into a transparent or translucent twinwall plastic sheet, similar in construction to corrugated cardboard. The lamp (or LED) spacing is easily changed in order to alter the intensity of the light emitted by the lightpanel, the number of lamps (or LEDs) used and to change the “evenness” of the light across the panel. The twinwall plastic sheet is thin, durable and lightweight, protecting the fragile lamps and providing a simple method of mounting and wiring. The plastic sheet may also be slit on one, or both sides, yielding a flexible lightpanel; graduated dots or lines may be printed onto the surface of the plastic sheet or translucent materials may be used on the surface of the plastic sheet to assist in making the intensity of the light across the surface of the sheet more even.

Abstract: A child-resistant yet senior-friendly packaging for tablets, capsules or similar pharmaceutical products. The packaging is a blister pack (12) with at least one cup (22) that receives tablets (18) in an external package, arranged between a base part (14) and a cover part (16), and that is closed by a cover film (24) that can be pressed through. The cover film (24) of the blister pack (12) is directed towards the base part (14) and the base part (14) comprises an opening (38) through which the product can be withdrawn. The cup (22) of the blister pack (12) is displaceably guided in a slot (30) in the cover part (16) and can be brought in alignment with the opening (38) in the base part (14) so that the cover film (24) can be pressed through and the tablet (18) can be withdrawn. A tear tab (32) is detachably linked with the cover part (16) via a perforated line (36) and covers the slot (30) at least partially.