Patents by Inventor Michael Kubbutat

Michael Kubbutat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APTAMER AND USE OF THE APTAMER IN THE DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20220073921
    Abstract: The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1 or a fragment thereof of at least 20 contiguous nucleotides of the nucleotide sequence SEQ ID NO: 2, wherein the aptamer comprises a polyethylene glycol (PEG) moiety conjugated to the 5? or the 3? end. The invention further relates to a composition comprising the aptamer, and the use of the aptamer in the diagnosis and treatment of cancer, particularly hormone refractory prostate tumours.
    Type: Application
    Filed: January 20, 2020
    Publication date: March 10, 2022
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Frédéric DUCONGÉ, Andreas LINGNAU, Holger WEBER, Michael KUBBUTAT, Günter MAYER
  • Thioether derivatives as protein kinase inhibitors
    Patent number: 9925193
    Abstract: The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: March 27, 2018
    Assignee: ProQinase GmbH
    Inventors: Michael Kubbutat, Christoph Schachtele, Jan Ehlert, Frank Totzke, Conrad Kunick, Sebastian Wolfel, Holger Weber
  • Kinase modulators for the treatment of cancer
    Patent number: 9416123
    Abstract: Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 16, 2016
    Assignee: Synovo GmbH
    Inventors: Michael William Burnet, Bassam Abu Thaher, Jan Ehlert, Michael Kubbutat, Christoph Schaechtele, Frank Totzke
  • THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20150328219
    Abstract: The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.
    Type: Application
    Filed: November 11, 2013
    Publication date: November 19, 2015
    Inventors: Michael KUBBUTAT, Christoph SCHÄCHTELE, Jan EHLERT, Frank TOTZKE, Conrad KUNICK, Sebastian WÖLFEL, Holger WEBER
  • KINASE MODULATORS FOR THE TREATMENT OF CANCER
    Publication number: 20140336225
    Abstract: Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.
    Type: Application
    Filed: March 28, 2014
    Publication date: November 13, 2014
    Inventors: Michael William Burnet, Bassam Abu Thaher, Jan Ehlert, Michael Kubbutat, Christoph Schaechtele, Frank Totzke
  • Benzazole analogues and uses thereof
    Publication number: 20110172241
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents —Y are attached to the 5- or 6-position of the benzazole.
    Type: Application
    Filed: March 23, 2011
    Publication date: July 14, 2011
    Applicant: 4SC AG
    Inventors: Thomas HERZ, Rolf KRAUSS, Michael KUBBUTAT, Martin LANG, Christoph SCHAECHTELE, Stefan TASLER, Frank TOTZKE
  • BENZAZOLE ANALOGUES AND USES THEREOF
    Publication number: 20090270410
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents -Y are attached to the 5- or 6-position of the benzazole.
    Type: Application
    Filed: July 7, 2009
    Publication date: October 29, 2009
    Applicant: 4SC AG
    Inventors: Thomas HERZ, Rolf KRAUSS, Michael KUBBUTAT, Martin LANG, Christoph SCHAECHTELE, Stefan TASLER, Frank TOTZKE
  • Benzazole analogues and uses thereof
    Patent number: 7576090
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents —Y are attached to the 5- or 6-position of the benzazole.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 18, 2009
    Assignee: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke
  • Benzazole analogues and uses thereof
    Patent number: 7514460
    Abstract: The present invention relates to N2-heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: April 7, 2009
    Assignee: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke
  • 2-arylbenzothiazole analogues and uses thereof
    Publication number: 20070021446
    Abstract: The present invention relates to compounds of the general formula (I) and salts, prodrugs, and stereoisomers thereof, wherein Y independently represents S, O, NR2, SO, SO2; A independently represents a fife- or six-membered aromatic carbocycle or heterocycle and wherein R1 to R20 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.
    Type: Application
    Filed: May 16, 2006
    Publication date: January 25, 2007
    Applicant: 4SC AG
    Inventors: Jan Ehlert, Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Wael Saeb, Christoph Schaechtele, Stefan Tasler, Frank Totzke, Ute Zirrgiebel
  • Benzazole analogues and uses thereof
    Publication number: 20060142570
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents —Y are attached to the 5- or 6-position of the benzazole.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Applicant: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke
  • Benzazole analogues and uses thereof
    Publication number: 20060135782
    Abstract: The present invention relates to N2-heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 22, 2006
    Applicant: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke