Patents by Inventor Michael Kukla
Michael Kukla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230281230Abstract: A computerized system and methods are provided for the automated extraction of contextually relevant information, and the automatic processing of actionable information from generic document sets. More specifically, automated systems and techniques for the extraction and processing of opportunity documents, are provided, which avoid inaccuracies and inefficiencies resulting from conventional and/or human-based document processing techniques.Type: ApplicationFiled: January 30, 2023Publication date: September 7, 2023Inventors: James Michael Kukla, Jeehye Yun
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Patent number: 11567979Abstract: A computerized system and methods are provided for the automated extraction of contextually relevant information, and the automatic processing of actionable information from generic document sets. More specifically, automated systems and techniques for the extraction and processing of opportunity documents, are provided, which avoid inaccuracies and inefficiencies resulting from conventional and/or human-based document processing techniques.Type: GrantFiled: October 15, 2020Date of Patent: January 31, 2023Assignee: RedShred LLCInventors: James Michael Kukla, Jeehye Yun
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Publication number: 20210240748Abstract: A computerized system and methods are provided for the automated extraction of contextually relevant information, and the automatic processing of actionable information from generic document sets. More specifically, automated systems and techniques for the extraction and processing of opportunity documents, are provided, which avoid inaccuracies and inefficiencies resulting from conventional and/or human-based document processing techniques.Type: ApplicationFiled: October 15, 2020Publication date: August 5, 2021Inventors: James Michael Kukla, Jeehye Yun
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Patent number: 10810240Abstract: A computerized system and methods are provided for the automated extraction of contextually relevant information, and the automatic processing of actionable information from generic document sets. More specifically, automated systems and techniques for the extraction and processing of opportunity documents, are provided, which avoid inaccuracies and inefficiencies resulting from conventional and/or human-based document processing techniques.Type: GrantFiled: November 7, 2016Date of Patent: October 20, 2020Assignee: RedShred LLCInventors: James Michael Kukla, Jeehye Yun
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Publication number: 20170132313Abstract: A computerized system and methods are provided for the automated extraction of contextually relevant information, and the automatic processing of actionable information from generic document sets. More specifically, automated systems and techniques for the extraction and processing of opportunity documents, are provided, which avoid inaccuracies and inefficiencies resulting from conventional and/or human-based document processing techniques.Type: ApplicationFiled: November 7, 2016Publication date: May 11, 2017Inventors: James Michael Kukla, Jeehye Yun
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Publication number: 20080108653Abstract: The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.Type: ApplicationFiled: October 30, 2007Publication date: May 8, 2008Inventors: Henry Breslin, Hans De Winter, Michael Kukla
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Publication number: 20060276509Abstract: The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.Type: ApplicationFiled: August 7, 2006Publication date: December 7, 2006Inventors: Henry Breslin, Hans De Winter, Michael Kukla
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Publication number: 20060189614Abstract: This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino-C1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1 is optionally substituted phenyl; for the manufacture of a medicine for the treatment oType: ApplicationFiled: August 12, 2005Publication date: August 24, 2006Inventors: Paul Janssen, Jan Heeres, Henri Moereels, Michael Kukla, Donald Ludovici
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Publication number: 20060063789Abstract: This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21—C1-6alkyl; R21—O—; R21—S—; R21—C(?O)—; R21—S(?O)p—; R7—S(?O)p—; R7—S(?O)p—NH—; R21—S(?O)p—NH—; R7—C(?O)—; —NHC(?O)H; —C(?O)NHNH2; R7—C(?O)—NH—;Type: ApplicationFiled: October 29, 2002Publication date: March 23, 2006Inventors: Eddy Jean Freyne, Peter Antonius, Marc Willems, Werner Johan, Paul Janssen, Paulus Joannes, Jan Heeres, Marc de Jonge, Lucien Koymans, Frederik Daeyaert, Michael Kukla, Hugo Gabriel, Bony Nuydens, Marc Mercken, Donald Ludovici, Herwig Janssen, Paul Maria, Graziella Janssen, Jasmine Werner, Maroussia Janssen, Theodora Arts
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Publication number: 20060009474Abstract: The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(?O)—R8; —S(?O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formulaType: ApplicationFiled: September 13, 2005Publication date: January 12, 2006Inventors: Michael Kukla, Donald Ludovici, Robert Kavash, Bart De Corte, Jan Heeres, Paul Janssen, Lucien Koymans, Marc de Jonge, Koen Van Aken, Alain Krief
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Publication number: 20050288278Abstract: This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, substituted C1-6alkyl, or substituted C1-6alkyloxyC1-6alkylcarbonyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalo-methylthio, —S(?O)pR6, —NH—S(?O)pR6, —C(?O)R6, —NHC(?O)H, —C(?O)NHNH2, —NHC(?O)R6, —C(?NH)R6 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substType: ApplicationFiled: August 16, 2005Publication date: December 29, 2005Inventors: Bart De Corte, Marc De Jonge, Jan Heeres, Chih Ho, Paul Janssen, Robert Kavash, Lucien Koymans, Michael Kukla, Donald Ludovici, Koen Van Aken
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Publication number: 20050277641Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein ?a1=a2?a3=a4—forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(?O)pR4, —NH—S(?O)pR4, —C(?O)R4, —NHC(?O)H, —C(?O)NHNH2, —NHC(?O)R4, —C(?NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyraType: ApplicationFiled: August 27, 2003Publication date: December 15, 2005Inventors: Bart De Corte, Marc de Jonge, Jan Heeres, Paul Janssen, Robert Kavash, Lucien Koymans, Michael Kukla, Donald Ludovici, Koen Van Aken
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Publication number: 20050197354Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl.Type: ApplicationFiled: April 21, 2005Publication date: September 8, 2005Inventors: Koenraad Jozef Andries, Bart De Corte, Marc De Jonge, Jan Heeres, Chih Ho, Marcel Janssen, Paul Janssen, Lucien Koymans, Michael Kukla, Donald Ludovici, Koen Van Aken
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Publication number: 20050192305Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted: or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl,; and R4 is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R5 is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl: or L is —X1—R6 or —X2-Alk-R7 wherein R6 and R7Type: ApplicationFiled: April 21, 2005Publication date: September 1, 2005Inventors: Koenraad Jozef Andries, Bart De Corte, Marc De Jonge, Jan Heeres, Chih Ho, Marcel Janssen, Paul Janssen, Lucien Koymans, Michael Kukla, Donald Ludovici, Koen Van Aken