Abstract: The invention provides novel substituted amino triazoles of Formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as well as pharmaceutical compositions comprising the same. The compounds of the invention are inhibitors of acidic mammalian chitinase (AMCase) and are useful, in a non-limiting embodiment, for treating asthma. The invention further provides methods of using compounds and/or compositions of the invention to treat asthma and/or to monitor asthma treatment.

Abstract: Disclosed are novel substituted amino triazoles of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of Formula (I) are inhibitors of Acidic mammalian chitinase (AMCase) and are useful, in a non-limiting example, for treating asthma. Also provided are pharmaceutical compositions containing at least one compound of the present invention, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and at least one pharmaceutically acceptable carrier, solvent, adjuvant or diluent, and methods of using such compounds and/or compositions to treat asthma and/or to monitor asthma treatment.

Abstract: The invention provides compounds of Formula I: 1