Abstract: Provided herein are methods of treating a subject by administering a combination of an activatable cytokine construct (ACC) and a PD-1/PD-L1 pathway inhibitor in which the ACC includes: a first monomer construct including an optional first peptide mask (PM1), an optional third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1; and a second monomer construct including an optional second peptide mask (PM2), an optional forth cleavable moiety (CM4), a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), wherein the CM2 is positioned between the CP2 and the DD2; wherein the DD1 and the DD2 bind to each other thereby forming a dimer of the first monomer construct and the second monomer construct; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control l

Abstract: Radio-controlled fishing apparatus is provided including a hand-held radio signal generator which is integrally formed with a telescoping fishing rod. A fishing line extends from the rod to a miniature boat which includes a radio signal receiver and an electric motor which drives a propeller. The method of use includes guiding the boat to a suitable fishing location or along a trolling route by the radio signal generator whereupon a fish striking the attached bait can be manually reeled in, along with the boat. A slip attachment connected to the fishing line allows the line to quickly release from the boat thereby freeing the line as the fish is played, but allowing the boat to be simultaneously returned to the operator with the fish.