Patents by Inventor Michael L. Hutton

Michael L. Hutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting and treating dementia
    Patent number: 9486541
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: November 8, 2016
    Assignees: Mayo Foundation for Medical Education and Research, VIB VZW, Universteit Antwerpen, The University of British Columbia, The University of Manchester
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20130345142
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: July 1, 2013
    Publication date: December 26, 2013
    Applicants: Mayo Foundation for Medical Education and Research, Vib VZW, The University of Manchester, The University of British Columbia, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • Detecting and treating dementia
    Patent number: 8486635
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: July 16, 2013
    Assignees: Mayo Foundation for Medical Education and Research, The University of British Columbia, The University of Manchester, VIB VZW, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20100105034
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: May 30, 2007
    Publication date: April 29, 2010
    Inventors: Michael L. Hutton, Matthew Colin Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts
  • Pathogenic Tau mutations in transgenic mice
    Patent number: 6664443
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: December 16, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael L. Hutton, Jada M. Lewis, Eileen M. McGowan
  • Pathogenic tau mutations
    Patent number: 6475723
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: November 5, 2002
    Assignees: Mayo Foundation for Medical Education and Research, Washington University, Erasmus Universiteit Rotterdam, The Victoria University of Manchester
    Inventors: Michael L. Hutton, Peter Heutink, Alison M. Goate, Stuart M. Brown
  • PATHOGENIC TAU MUTATIONS
    Publication number: 20020026651
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.
    Type: Application
    Filed: April 30, 1999
    Publication date: February 28, 2002
    Inventors: Michael L. Hutton, Peter Heutink, Alison M. Goate, Stuart M. Brown