Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: A head-mounted device is provided that includes one or more cameras configured to acquire a raw video feed and one or more displays configured to present a passthrough video feed to a user. Generation of the passthrough video feed can involve processing the raw video feed using an image signal processor and auxiliary compute blocks. One or more of the auxiliary compute blocks can be bypassed in response to detecting one or more failures associated with the auxiliary compute blocks. Configured and operated in this way, the head-mounted device can fall back to a more reliable passthrough video feed without having to power cycle the head-mounted device when a failure occurs.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: A method for forming a porous implant suitable for a cavity from which tissue has been removed includes incorporating a gas or a pore forming agent into an alginate solution; transferring the alginate solution with the gas or the pore forming agent into a solidified body mold having a desired shape with an outer surface; removing the water from the solidified body; and subjecting the solidified body to a conversion solution to convert the outer surface to a less soluble alginate creating a composition comprising the outer surface having less soluble alginate and a core having more soluble alginate.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: At least one of a measure of trust or a measure of spoofing risk associated with a sender of a message is determined. A measure of similarity between an identifier of the sender of the message and an identifier of at least one trusted contact of a recipient of the message is determined. The measure of similarity is combined with at least one of the measure of trust or the measure of spoofing risk to at least in part determine a combined measure of risk associated with the message. Based at least in part on the combined measure of risk associated with the message, a verification action is performed including by automatically providing an inquiry message that requests a response to be provided.

Abstract: At least one of a measure of trust or a measure of spoofing risk associated with a sender of a message is determined. A measure of similarity between an identifier of the sender of the message and an identifier of at least one trusted contact of a recipient of the message is determined. The measure of similarity is combined with at least one of the measure of trust or the measure of spoofing risk to at least in part determine a combined measure of risk associated with the message. Based at least in part on the combined measure of risk associated with the message, a verification action is performed including by automatically providing an inquiry message that requests a response to be provided.

Abstract: Systems and methods for providing a payment messaging interface may include receiving, at a computing device comprising a processor, transaction information regarding the transaction. Once the transaction information is received, the transaction information may be translated into a data structure that corresponds to a payment processor. Once the transaction information has been translated, the data structure may be transmitted to the payment processor.

Abstract: At least one of a measure of trust or a measure of spoofing risk associated with a sender of a message is determined. A measure of similarity between an identifier of the sender of the message and an identifier of at least one trusted contact of a recipient of the message is determined. The measure of similarity is combined with at least one of the measure of trust or the measure of spoofing risk to at least in part determine a combined measure of risk associated with the message. Based at least in part on the combined measure of risk associated with the message, a verification action is performed including by automatically providing an inquiry message that requests a response to be provided.

Abstract: At least one of a measure of trust or a measure of spoofing risk associated with a sender of a message is determined. A measure of similarity between an identifier of the sender of the message and an identifier of at least one trusted contact of a recipient of the message is determined. The measure of similarity is combined with at least one of the measure of trust or the measure of spoofing risk to at least in part determine a combined measure of risk associated with the message. The sender of the message is not included in the at least one trusted contact of the recipient of the message. Based at least in part on the combined measure of risk associated with the message, the message is modified to alter content of a data field that includes an identification of the sender of the message.

Abstract: A first risk analysis of a message is performed. In the event the first risk analysis results in a determination that the message meets a first criteria, at least a portion of the message is modified prior to sending a modified version of the message to a specified recipient of the message, and a second risk analysis of the message is performed. The first risk analysis is performed before sending the modified version of the message and the modified version of the message is sent to the specified recipient of the message prior to a conclusion of the second risk analysis. In the event the second risk analysis results in a determination that the message meets a second criteria, content of the message that was previously prevented from being accessed by the specified recipient is provided to the specified recipient of the message.

Abstract: A method for forming a porous implant suitable for a cavity from which tissue has been removed includes incorporating a gas or a pore forming agent into an alginate solution; transferring the alginate solution with the gas or the pore forming agent into a solidified body mold having a desired shape with an outer surface; removing the water from the solidified body; and subjecting the solidified body to a conversion solution to convert the outer surface to a less soluble alginate creating a composition comprising the outer surface having less soluble alginate and a core having more soluble alginate.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: A first risk analysis of a message is performed. In the event the first risk analysis results in a determination that the message meets a first criteria, at least a portion of the message is modified prior to sending a modified version of the message to a specified recipient of the message, and a second risk analysis of the message is performed. The first risk analysis is performed before sending the modified version of the message and the modified version of the message is sent to the specified recipient of the message prior to a conclusion of the second risk analysis. In the event the second risk analysis results in a determination that the message meets a second criteria, content of the message that was previously prevented from being accessed by the specified recipient is provided to the specified recipient of the message.

Abstract: In one form, the invention is directed to a method for forming a porous implant suitable for a cavity from which tissue has been removed, including mixing soluble alginate and a radiopaque imaging agent with water; incorporating a gas or a pore forming agent into the alginate-water mixture; transferring the alginate-water mixture with the gas or the pore forming agent into a mold to form the mixture into a solid body of desired shape; removing the water from the body; and converting at least part of the soluble alginate to a less soluble alginate. In another form, the invention includes forming a mixture by mixing about 0.5 percent to about 4 percent by weight chitosan into an acidified aqueous solution containing 1 percent to 25 percent by weight acetic acid, along with about 0.5 percent to about 5 percent by weight of a powdered radiopaque imaging agent.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

Abstract: Systems and methods for activating a remote device may include receiving, at a computing device, an authorization request regarding the transaction. The authorization request may be received from a user mobile device. Once the authorization request is received, the translation information may be translated into a data structure that corresponds to a payment processor. The data structure may be transmitted to the payment processor. An authorization message may be transmitted to a point-of sale device.