Patents by Inventor Michael L. Kotewicz

Michael L. Kotewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloned genes encoding reverse transcriptase lacking RNase H activity
    Patent number: 5405776
    Abstract: The invention relates to a gene which encodes reverse transcriptase having DNA polymerase activity and substantially no RNase H activity. The invention also relates to vectors containing the gene and hosts transformed with the vectors of the invention. The invention also relates to a method of producing reverse transcriptase having DNA polymerase activity and substantially no RNase H activity by expressing the reverse transcriptase genes of the present invention in a host. The invention also relates to a method of producing cDNA from mRNA using the reverse transcriptase of the invention. The invention also relates to a kit for the preparation of cDNA from mRNA comprising the reverse transcriptase of the invention.
    Type: Grant
    Filed: January 24, 1992
    Date of Patent: April 11, 1995
    Assignee: Life Technologies, Inc.
    Inventors: Michael L. Kotewicz, Gary F. Gerard
  • Cloned genes encoding reverse transcriptase lacking RNase H activity
    Patent number: 5244797
    Abstract: The invention relates to a gene which encodes reverse transcriptase having DNA polymerase activity and substantially no RNase H activity. The invention also relates to vectors containing the gene and hosts transformed with the vectors of the invention. The invention also relates to a method of producing reverse transcriptase having DNA polymerase activity and substantially no RNase H activity by expressing the reverse transcriptase genes of the present invention in a host. The invention also relates to a method of producing cDNA from mRNA using the reverse transcriptase of the invention. The invention also relates to a kit for the preparation of cDNA from mRNA comprising the reverse transcriptase of the invention.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: September 14, 1993
    Assignee: Life Technologies, Inc.
    Inventors: Michael L. Kotewicz, Gary F. Gerard
  • Reverse transcriptase and method for its production
    Patent number: 5017492
    Abstract: The cloning of truncated versions of Moloney murine leukemia virus reverse transcriptase enzyme in E. coli is disclosed. The truncated reverse transcriptase enzymes have improved half-life when compared to native reverse transcriptase.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: May 21, 1991
    Assignee: Life Technologies, Inc.
    Inventors: Michael L. Kotewicz, James M. D'Alessio, Gary F. Gerard