Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A CPE device may include a plurality of CPE modules implemented in hardware. The plurality of CPE modules may include a first module and a second module. The first module and the second module may be arrangeable in a stacked configuration. The first module may include a first interconnection interface component disposed on a top surface of the first module. The second module may include a second interconnection interface component disposed on a bottom surface of the second module. The second interconnection interface component may be configured to complementarily couple to the first interconnection interface component when the first module and the second module are arranged in the stacked configuration.

Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying the liquid into powder particles, removing oxygen from surfaces of the powder particles to reduce a bulk oxygen content to approximately ?20 ppm, and consolidating the powder particles into a monolithic article.

Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C 0.03 max Mn 1.0 max Si 0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu 0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.

Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying of the liquid into powder particles, outgassing to remove oxygen from the surface of the powder particles, and consolidating the powder particles into a monolithic article.

Abstract: Various systems and methods for implementing EMG-based liveness detection are described herein. An EMG-based liveness detection system incorporated into a wearable device includes a plurality of electrodes to sense EMG signal data of a user; an amplifier to amplify the EMG signal data; a filter to remove signal noise from the EMG signal data; an analog-to-digital converter to analyze the EMG signal data and convert it to digital data; and a controller to: authenticate the user; perform an EMG-based liveness test of the user based on the digital data; and disable the wearable device when the EMG-based liveness test fails.

Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C 0.03 max Mn 1.0 max Si 0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu 0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.

Abstract: A corrosion resistant, neutron absorbing, austenitic alloy powder is disclosed having the following composition in weight percent. C 0.08 max. Mn up to 3 Si up to 2 P 0.05 max. S 0.03 max. Cr 17-27 Ni 11-20 Mo + (W/1.92) ??up to 5.2 BEq 0.78-13.0 O ?0.1 max. N ??up to 0.2 Y less than 0.005 The alloy contains at least about 0.25% B, at least about 0.05% Gd, and the balance of the alloy composition is iron and usual impurities. BEq is defined as % B+4.35×(% Gd). An article of manufacture made from consolidated alloy powder is also disclosed which is characterized by a plurality of boride and gadolinide particles dispersed within a matrix. The boride and gadolinide particles are predominantly M2B, M3B2, M3X, and M5X in form, where X is gadolinium or a combination of gadolinium and boron and M is one or more of the elements silicon, chromium, nickel, molybdenum, iron.

Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying of the liquid into powder particles, outgassing to remove oxygen from the surface of the powder particles, and consolidating the powder particles into a monolithic article.

Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C ?0.03 max Mn ?1.0 max Si ?0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu ?0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.

Abstract: A corrosion resistant, neutron absorbing, austenitic alloy powder is disclosed having the following composition in weight percent. C 0.08 max. Mn up to 3 Si up to 2 P 0.05 max. S 0.03 max. Cr 17-27 Ni 11-20 Mo + (W/1.92) ??up to 5.2 BEq 0.78-13.0 O ?0.1 max. N ??up to 0.2 Y less than 0.005 The alloy contains at least about 0.25% B, at least about 0.05% Gd, and the balance of the alloy composition is iron and usual impurities. BEq is defined as % B+4.35×(% Gd). An article of manufacture made from consolidated alloy powder is also disclosed which is characterized by a plurality of boride and gadolinide particles dispersed within a matrix. The boride and gadolinide particles are predominantly M2B, M3B2, M3X, and M5X in form, where X is gadolinium or a combination of gadolinium and boron and M is one or more of the elements silicon, chromium, nickel, molybdenum, iron.

Abstract: An age hardenable martensitic steel alloy having a unique combination of very high strength and good toughness consists essentially of, in weight percent, about______________________________________ C 0.21-0.34 Mn 0.20 max. Si 0.10 max. P 0.008 max. S 0.003 max. Cr 1.5-2.80 Mo 0.90-1.80 Ni 10-13 Co 14.0-22.0 Al 0.1 max. Ti 0.05 max. Ce 0.030 max. La 0.010 max. ______________________________________the balance essentially iron. In addition, cerium and sulfur are balanced so that the ratio Ce/S is at least about 2 and not more than about 15. A small but effective amount of calcium can be present in place of some or all of the cerium and lanthanum.

Abstract: A web coater is provided with a doctor blade having an active edge or tip engaging the web at a predetermined position. The force applied by such active edge is adjusted by movement of jaws gripping the opposite edge of the blade. The jaws are moved along a curve empirically established to maintain the active edge of the blade in a predetermined fixed position during the adjustment. The angle of incidence of the active edge of the blade relative to the web is also maintained constant by pivoting a blade supporting frame about an axis coincident with the active edge. A controller is supplied with empirically established data developed by utilizing test blades to establish polynomial formulas having constants corresponding to each of the various blades intended to be used by the coater. The controller also automatically compensates for blade wear.

Abstract: A high strength, high fracture toughness steel alloy consisting essentially of, in weight percent, about______________________________________ C 0.2-0.33 Mn 0.20 max. Si 0.1 max. P 0.008 max. S 0.004 max. Cr 2-4 Ni 10.5-15 Mo 0.75-1.75 Co 8-17 Ce Effective amount-0.030 La Effective amount-0.01 Fe Balance ______________________________________and an article made therefrom are disclosed. A small but effective amount of calcium can be present in this alloy in substitution for some or all of the cerium and lanthanum. The alloy is an age-hardenable martensitic steel alloy which provides a unique combination of tensile strength and fracture toughness. The alloy provides excellent mechanical properties when hardened by vacuum heat treatment with inert gas cooling and has a low ductile-to-brittle transition temperature.

Abstract: A web coater is provided with a doctor blade having an active edge or tip engaging the web at a predetermined position. The force applied by such active edge is adjusted by movement of jaws gripping the opposite edge of the blade. The jaws are moved along a curve empirically established to maintain the active edge of the blade in a predetermined fixed position during the adjustment. The angle of incidence of the active edge of the blade relative to the web is also maintained constant by pivoting a blade supporting frame about an axis coincident with the active edge. A controller is supplied with empirically established data developed by utilizing test blades to establish polynomial formulas having constants corresponding to each of the various blades intended to be used by the coater. The controller also automatically compensates for blade wear.

Abstract: An improved hot work tool steel has higher hardness capability and better temper resistance above 1100 F. and better wear resistance than AISI type H13 and better toughness and ductility then AISI type H10 or type H21. The steel alloy contains essentially the following in weight percent:______________________________________ Carbon 0.55 Max. Manganese 1.5 Max. Silicon 2.0 Max. Chromium 3.5-6.0 Molybdenum 1.5-3.0 Vanadium 0.50-1.50 ______________________________________and the balance is essentially iron except for the usual impurities found in commerical grades of hot work tool steels. Carbon and chromium are balanced within the composition such that% carbon.gtoreq.0.098.times.% chromium.

Abstract: A low cobalt maraging steel has a yield strength of at least about 240 ksi (about 1655 MPa) in the aged condition in combination with good toughness as indicated by a longitudinal Charpy V-notch impact toughness of at least aobut 20 ft-lb (about 27 J), as well as good notch ductility. The alloy contains, in weight percent, about:______________________________________ w/o ______________________________________ C 0.02 Max. Ni 15-20 Mo 0.50-4.0 Co 0.5-5.0 Ti 0.90-1.35 Nb 0.03-0.35 Al 0.3 Max. B Up to 0.015 ______________________________________The balance is essentially iron, optional additions, and the usual impurities found in commercial grades of high nickel, low carbon maraging steels. The alloy is further characterized in that the ratio %Co:%Mo is at least about 0.3 and %Ti+%Nb.gtoreq.1.0.