Patents by Inventor Michael L. Simpson
Michael L. Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8993327Abstract: Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.Type: GrantFiled: April 7, 2003Date of Patent: March 31, 2015Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Guy D. Griffin, Michael A. Guillorn, Vladimir L. Merkulov, Michael L. Simpson
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Patent number: 8343766Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: GrantFiled: November 28, 2011Date of Patent: January 1, 2013Assignee: UT-Battle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8142877Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoconduit material coupled to a surface of the substrate. The substrate defines an aperture and the nanoconduit material defines a nanoconduit that is i) contiguous with the aperture and ii) aligned substantially non-parallel to a plane defined by the surface of the substrate.Type: GrantFiled: November 13, 2007Date of Patent: March 27, 2012Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20120070895Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: ApplicationFiled: November 28, 2011Publication date: March 22, 2012Applicant: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8101388Abstract: The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.Type: GrantFiled: September 28, 2007Date of Patent: January 24, 2012Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8076124Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: GrantFiled: January 17, 2007Date of Patent: December 13, 2011Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 8003220Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.Type: GrantFiled: November 13, 2007Date of Patent: August 23, 2011Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7947976Abstract: Systems and methods are described for controlled alignment of catalytically grown nanostructures in a large-scale synthesis process. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.Type: GrantFiled: July 28, 2008Date of Patent: May 24, 2011Assignee: UT-Battelle, LLCInventors: Vladimir I. Merkulov, Anatoli V. Melechko, Michael A. Guillorn, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7943196Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.Type: GrantFiled: November 14, 2005Date of Patent: May 17, 2011Assignee: UT-Battelle, LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7641863Abstract: A nanoengineered membrane for controlling material transport (e.g., molecular transport) is disclosed. The membrane includes a substrate, a cover defining a material transport channel between the substrate and the cover, and a plurality of fibers positioned in the channel and connected to and extending away from a surface of the substrate. The fibers are aligned perpendicular to the surface of the substrate, and have a width of 100 nanometers or less. The diffusion limits for material transport are controlled by the separation of the fibers. In one embodiment, chemical derivatization of carbon fibers may be undertaken to further affect the diffusion limits or affect selective permeability or facilitated transport. For example, a coating can be applied to at least a portion of the fibers. In another embodiment, individually addressable carbon nanofibers can be integrated with the membrane to provide an electrical driving force for material transport.Type: GrantFiled: March 6, 2003Date of Patent: January 5, 2010Assignee: UT-Battelle LLCInventors: Mitchel J. Doktycz, Michael L. Simpson, Timothy E. McKnight, Anatoli V. Melechko, Douglas H. Lowndes, Michael A. Guillorn, Vladimir I. Merkulov
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Publication number: 20090087899Abstract: The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.Type: ApplicationFiled: September 28, 2007Publication date: April 2, 2009Inventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Publication number: 20090081415Abstract: Systems and methods are described for controlled alignment of catalytically grown nanostructures in a large-scale synthesis process. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.Type: ApplicationFiled: July 28, 2008Publication date: March 26, 2009Inventors: Vladimir I. Merkulov, Anatoli V. Melechko, Michael A. Guillorn, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20080290326Abstract: Systems and methods are described for controlled alignment of catalytically grown nanostructures in a large-scale synthesis process. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.Type: ApplicationFiled: July 28, 2008Publication date: November 27, 2008Inventors: Vladimir I. Merkulov, Anatoli V. Melechko, Michael A. Guillorn, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7408186Abstract: Systems and methods are described for controlled alignment of catalyticaly grown nanostructures in a large-scale synthesis process. A composition includes an elongated nanostructure including a first segment defining a first axis and a second segment coupled to the first segment, the second segment defining a second axis that is substantially nonparallel to the first axis. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.Type: GrantFiled: March 24, 2005Date of Patent: August 5, 2008Assignee: UT-Battelle LLCInventors: Vladimir I. Merkulov, Anatoli V. Melechko, Michael A. Guillorn, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20080182068Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.Type: ApplicationFiled: November 13, 2007Publication date: July 31, 2008Inventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir L. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Publication number: 20080171386Abstract: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.Type: ApplicationFiled: January 17, 2007Publication date: July 17, 2008Inventors: Timothy E. McKnight, Anatoli V. Melechko, Michael L. Simpson
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Patent number: 7371538Abstract: An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the photodetector is preferably used to raise efficiency.Type: GrantFiled: June 14, 2005Date of Patent: May 13, 2008Assignee: UT-Battelle, LLCInventors: Michael L. Simpson, Michael J. Paulus, Gary S. Sayler, Bruce M. Applegate, Steven A. Ripp
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Patent number: 7245068Abstract: Systems and methods are described for controlled alignment of catalyticaly grown nanostructures in a large-scale synthesis process. An apparatus includes an electrode including: a protruding section defining an edge; and a nonprotruding section coupled to the protruding section, where the edge is adapted to deflect an electric field generated with the electrode and at least one section selected from the group consisting of the protruding section and the nonprotruding section is adapted to support a substrate for the growth of elongated nanostructures.Type: GrantFiled: March 24, 2005Date of Patent: July 17, 2007Assignee: UT-Battelle, LLCInventors: Vladimir I. Merkulov, Anatoli V. Melechko, Michael A. Guillorn, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7229692Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus includes a substrate and a nanoconduit material coupled to a surface of the substrate, where the substrate defines an aperture and the nanoconduit material defines a nanoconduit that is i) contiguous with the aperture and ii) aligned substantially non-parallel to a plane defined by the surface of the substrate. An apparatus includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.Type: GrantFiled: February 9, 2004Date of Patent: June 12, 2007Assignee: UT-Battelle LLCInventors: Anatoli V. Melechko, Timothy E. McKnight, Michael A. Guillorn, Bojan Ilic, Vladimir I. Merkulov, Mitchel J. Doktycz, Douglas H. Lowndes, Michael L. Simpson
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Patent number: 7208286Abstract: Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably incorporated into the chromosome of the microorganism and an Optical Application Specific Integrated Circuit (OASIC). The microorganism is generally a bacterium.Type: GrantFiled: June 14, 2005Date of Patent: April 24, 2007Assignee: UT-Battelle LLCInventors: Michael L. Simpson, Michael J. Paulus, Gary S. Sayler, Bruce M. Applegate, Steven A. Ripp