Abstract: The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with dysregulation of the complement alternative pathway by administering a Complement Factor B (CFB) specific inhibitor to a subject.

Abstract: A method of processing. The method includes attaching a plurality of studs to a blank comprising a material having a first size approximating a second size of a part to be machined from the blank. The method also includes attaching a number of the plurality of studs to a tool tab. The method also includes attaching the tool tab to a tooling fixture. The method also includes removing material from the blank to form a finished part, wherein the plurality of studs remain attached to the blank during removing. The method also includes detaching the plurality of studs from the finished part.

Abstract: A method is provided for improving the machinability of a titanium alloy includes heating the alloy at a temperature and time period that imparts to the alloy a microstructure having between about 10 and 15 vol. % alpha phase in a beta phase matrix. According to one embodiment, the alloy is thereafter annealed at a temperature lower than the temperature for the initial heating step, and for a duration that is longer than the time period for the initial heating step.

Abstract: A method for processing parts. In one advantageous embodiment, a setoff set of studs are welded to a part to form a set of fixed studs. A set of tabs are attached to the set of fixed studs. The set of tabs are affixed to a manufacturing tool.

Abstract: A method for processing parts. In one advantageous embodiment, a setoff set of studs are welded to a part to form a set of fixed studs. A set of tabs are attached to the set of fixed studs. The set of tabs are affixed to a manufacturing tool.

Abstract: A method is provided for improving the machinability of a titanium alloy includes heating the alloy at a temperature and time period that imparts to the alloy a microstructure having between about 10 and 15 vol. % alpha phase in a beta phase matrix. According to one embodiment, the alloy is thereafter annealed at a temperature lower than the temperature for the initial heating step, and for a duration that is longer than the time period for the initial heating step.

Abstract: A portable precision flange grinder grinds a flange on a duct. The flange has an axis, a radius, and a periphery. A mount mounts the grinder within the duct. The mount attaches to openings at ends of the duct. A grinding wheel grinds a flange on a duct and arranged to rotate along a periphery of the flange. A first linkage translates the grinding wheel along an axis of the flange to bring the grinding wheel laterally in grinding contact with the flange. The first linkage engages with the mount along an axis of the flange. A second linkage translates the grinding wheel along a radius of the flange bringing the grinding wheel radially in grinding contact with the flange. The second linkage attaches to the first linkage. A bearing assembly rotates the grinding wheel about the periphery of the flange. The bearing assembly is attached to the first linkage.

Abstract: A portable precision flange grinder grinds a flange on a duct. The flange has an axis, a radius, and a periphery. A mount mounts the grinder within the duct. The mount attaches to openings at ends of the duct. A grinding wheel grinds a flange on a duct and arranged to rotate along a periphery of the flange. A first linkage translates the grinding wheel along an axis of the flange to bring the grinding wheel laterally in grinding contact with the flange. The first linkage engages with the mount along an axis of the flange. A second linkage translates the grinding wheel along a radius of the flange bringing the grinding wheel radially in grinding contact with the flange. The second linkage attaches to the first linkage. A bearing assembly rotates the grinding wheel about the periphery of the flange. The bearing assembly is attached to the first linkage.

Abstract: A synchronously pumped optical parametric oscillator (OPO) using a temperature tuned 90 degree phase matched LBO crystal is disclosed which provides a broad selection of output wavelengths. In one embodiment a Ti:sapphire pump source having a cavity length matched to the OPO cavity length pumps a cavity with an LBO crystal located at the cavity waist of the cavity mode. Resources are included to, tune the OPO to a desired wavelength, repetitively scan through a series of desired wavelengths, and adjust the cavity length to obtain a synchronous pumping condition and diagnose a wavelength at which the OPO is operating. A frequency doubled beam in the LBO crystal is generated as a substantially collinear alignment beam.

Abstract: A synchronously pumped optical parametric oscillator (OPO) using a temperature-tuned 90.degree. phase matched LBO crystal is disclosed which provides a broad selection of output wavelengths. A Ti:Sapphire pump source having a cavity length matched to the OPO cavity length pumps a cavity with an LBO crystal located at the cavity waist of the cavity mode.

Abstract: A hole is formed in a high-strength steel part and a lubricant consisting essentially of one or more metal powders, preferably of nickel or molybdenum; a metal powder which is more reactive than the steel of the workpiece such as zinc; and an organic medium is applied. A forming mandrel having a generally cylindrical shape with a frustoconical portion on either end is centered over the hole. The mandrel is pushed through the hole at a rate such that the steel adjacent the hole is coldworked and its microstructure is transformed from an austenitic to a normal tempered martensitic structure.

Abstract: A mode locked pulsed laser incorporates an intracavity element to compensate for the dispersion caused by other intracavity elements. This element reduces the tendency of the pulse to broaden in the cavity due to group velocity dispersion and results in very short pulses. In the laser of the present invention, mode locking is initiated by detecting the beat frequency between adjacent longitudinal modes using a high speed photodiode. This signal is amplified and then the frequency is divided by two. The signal is passed through an electronically adjustable phase shifter and then to a power amplifier. This signal is applied to the acousto-optic modelocker. If the cavity length drifts the beat frequency between the longitudinal modes changes. The rf signal applied to the modulator changes in exactly the right manner to track the drift in cavity length. Thus the modelocker is automatically synched to the round trip of the laser cavity.

Abstract: A mode locked pulsed laser incorporates an intracavity element to compensate for the dispersion caused by other intracavity elements. This element reduces the tendency of the pulse to broaden in the cavity due to group velocity dispersion and results in very short pulses. In the laser of the present invention, mode locking is initiated by detecting the beat frequency between adjacent longitudinal modes using a high speed photodiode. This signal is amplified and then the frequency is divided by two. The signal is passed through an electronically adjustable phase shifter and then to a power amplifier. This signal is applied to the acousto-optic modelocker. If the cavity length drifts the beat frequency between the longitudinal modes changes. The rf signal applied to the modulator changes in exactly the right manner to track the drift in cavity length. Thus the modelocker is automatically synched to the round trip of the laser cavity.