Abstract: The present disclosure provides engineered tissue constructs having a population of cells. such as hepatocytes and stromal cells. and methods of implanting the same (e.g., for treating a disease or disorder, such as acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof).

Abstract: The present disclosure provides engineered tissue constructs having hepatocytes and stromal cells and methods of making and using the same (e.g., for treating acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof). The engineered tissue constructs may provide a microenvironment that promotes the persistence of hepatocyte survival for at least three months.

Abstract: A device, attachments, and method for grooming or cleaning the fur of an animal. The device includes a main unit, a steam delivery system operatively engaged with the main unit, and a liquid delivery system operatively engaged with the main unit. The steam delivery system is operable to selectively deliver a quantity of steam to the animal's fur and the liquid delivery system is operable to selectively deliver a volume of liquid to the animal's fur. The steam delivery system and liquid delivery system are selectively independently activated to perform a grooming or cleaning task with the device. One or more attachments are connectable with the main unit via a hose. Some of the attachments include a plurality of tines that extend outwardly in the direction of movement of the attachment along the animal's body and capture and lift hairs for improved application of liquid, shampoo, or air thereto.

Abstract: A cutting device for cutting rock includes a disc and a plurality of cutting elements secured to the disc. The disc is supported for rotation about an axis of rotation, and the disc includes a peripheral edge extending around the axis of rotation. The plurality of cutting elements are spaced apart along the peripheral edge of the disc and positioned in a cutting plane. Each of the cutting elements includes a base portion and a cutting portion including a cutting edge, and the cutting portion has a width that is larger than a width of the base portion.

Abstract: A cutting device for engaging a rock face includes a disc body supported for rotation about an axis of rotation, and a plurality of peripheral portions removably secured to the disc body. Each of the peripheral portions including a plurality of cutting bits positioned on a peripheral edge. The peripheral edge of each peripheral portion is aligned with the peripheral edges of adjacent peripheral portions.

Abstract: A cutting device for cutting rock includes a disc and a plurality of cutting elements secured to the disc. The disc is supported for rotation about an axis of rotation, and the disc includes a peripheral edge extending around the axis of rotation. The plurality of cutting elements are spaced apart along the peripheral edge of the disc and positioned in a cutting plane. Each of the cutting elements includes a base portion and a cutting portion including a cutting edge, and the cutting portion has a width that is larger than a width of the base portion.

Abstract: A conception device includes a dome having a collapsible sidewall, an annular rim, an integral dome rib, and three or more gripping flanges along the inner surface of the rim. The gripping flanges may effectively position and secure the device over the cervix for the concentration of semen on the cervical os to effect fertilization independently or with the aid of biologically active agents. The device may additionally include a handle extending from the annular rim at an angle.

Abstract: A cutting device for cutting rock includes a disc and a plurality of cutting elements secured to the disc. The disc is supported for rotation about an axis of rotation, and the disc includes a peripheral edge extending around the axis of rotation. The plurality of cutting elements are spaced apart along the peripheral edge of the disc and positioned in a cutting plane. Each of the cutting elements includes a base portion and a cutting portion including a cutting edge, and the cutting portion has a width that is larger than a width of the base portion.

Abstract: A cutting device for engaging a rock face includes a disc body supported for rotation about an axis of rotation, and a plurality of peripheral portions removably secured to the disc body. Each of the peripheral portions including a plurality of cutting bits positioned on a peripheral edge. The peripheral edge of each peripheral portion is aligned with the peripheral edges of adjacent peripheral portions.

Abstract: A cutting device for engaging a rock face includes a disc body supported for rotation about an axis of rotation, and a plurality of peripheral portions removably secured to the disc body. Each of the peripheral portions including a plurality of cutting bits positioned on a peripheral edge. The peripheral edge of each peripheral portion is aligned with the peripheral edges of adjacent peripheral portions.

Abstract: A cutting device for engaging a rock face includes a disc body supported for rotation about an axis of rotation, and a plurality of peripheral portions removably secured to the disc body. Each of the peripheral portions including a plurality of cutting bits positioned on a peripheral edge. The peripheral edge of each peripheral portion is aligned with the peripheral edges of adjacent peripheral portions.

Abstract: A conception device includes a dome having a collapsible sidewall, an annular rim, an integral dome rib, and three or more gripping flanges along the inner surface of the rim. The gripping flanges may effectively position and secure the device over the cervix for the concentration of semen on the cervical os to effect fertilization independently or with the aid of biologically active agents. The device may additionally include a handle extending from the annular rim at an angle.

Abstract: A cutting device for a cutting head includes a disc, a plurality of cutting elements secured to the disc, and a plurality of wear elements secured to the disc. The disc rotates about an axis of rotation, and the disc includes a peripheral edge. The cutting elements are spaced apart from one another along the peripheral edge of the disc. The wear elements are spaced apart from one another and from the cutting elements.

Abstract: Enabling an authenticated user to access content associated with an authenticated user as though the authenticated user had a selected user relationship with the authenticated user. The user relationship may comprise a relationship degree, a relationship category, a relationship rating, and/or the like. An invitation to join an electronic service, such as an online social network, is sent to the unauthenticated user at an address known to the authenticated user. The invitation includes a time-limited token, such as a URL, that includes an invitation identifier, which relates the invitation to the authenticated user content. The token may be encrypted in the invitation. The unauthenticated user returns the token as a request to preview the authenticated user content without first becoming an authenticated user of the electronic service. If the token is still valid, access is granted. The unauthenticated user may also request to establish a connection with the authenticated user.

Abstract: A cutting device for cutting rock includes a disc and a plurality of cutting elements secured to the disc. The disc is supported for rotation about an axis of rotation, and the disc includes a peripheral edge extending around the axis of rotation. The plurality of cutting elements are spaced apart along the peripheral edge of the disc and positioned in a cutting plane. Each of the cutting elements includes a base portion and a cutting portion including a cutting edge, and the cutting portion has a width that is larger than a width of the base portion.

Abstract: A cutting device for engaging a rock face includes a disc body supported for rotation about an axis of rotation, and a plurality of peripheral portions removably secured to the disc body. Each of the peripheral portions including a plurality of cutting bits positioned on a peripheral edge. The peripheral edge of each peripheral portion is aligned with the peripheral edges of adjacent peripheral portions.

Abstract: A cutting device for a cutting head includes a disc, a plurality of cutting elements secured to the disc, and a plurality of wear elements secured to the disc. The disc rotates about an axis of rotation, and the disc includes a peripheral edge. The cutting elements are spaced apart from one another along the peripheral edge of the disc. The wear elements are spaced apart from one another and from the cutting elements.

Abstract: Enabling an authenticated user to access content associated with an authenticated user as though the authenticated user had a selected user relationship with the authenticated user. The user relationship may comprise a relationship degree, a relationship category, a relationship rating, and/or the like. An invitation to join an electronic service, such as an online social network, is sent to the unauthenticated user at an address known to the authenticated user. The invitation includes a time-limited token, such as a URL, that includes an invitation identifier, which relates the invitation to the authenticated user content. The token may be encrypted in the invitation. The unauthenticated user returns the token as a request to preview the authenticated user content without first becoming an authenticated user of the electronic service. If the token is still valid, access is granted. The unauthenticated user may also request to establish a connection with the authenticated user.

Abstract: Enabling an unauthenticated user to access content associated with an authenticated user as though the unauthenticated user had a selected user relationship with the authenticated user. The user relationship may comprise a relationship degree, a relationship category, a relationship rating, and/or the like. An invitation to join an electronic service, such as an online social network, is sent to the unauthenticated user at an address known to the authenticated user. The invitation includes a time-limited token, such as a URL, that includes an invitation identifier, which relates the invitation to the authenticated user content. The token may be encrypted in the invitation. The unauthenticated user returns the token as a request to preview the authenticated user content without first becoming an authenticated user of the electronic service. If the token is still valid, access is granted. The unauthenticated user may also request to establish a connection with the authenticated user.

Abstract: A conception device includes a dome having a collapsible sidewall, an annular rim, and three or more gripping flanges along the inner surface of the rim. The gripping flanges may effectively position and secure the device over the cervix for the concentration of semen on the cervical os to effect fertilization independently or with the aid of biologically active agents. The device may additionally include a handle extending from the annular rim at an angle.