Patents by Inventor Michael Lajos Gallo

Michael Lajos Gallo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC RECEPTORS, BIOSENSOR HOST CELLS AND METHODS/USES THEREOF
    Publication number: 20190359937
    Abstract: A receptor is provided having a heterologous binding site that activates, when bound, a signaling domain related to the TNF receptor superfamily. Methods/uses of the foregoing in whole cell biosensors are also provided. There is also provided a library comprising a plurality of unique biosensor cells for binding unknown binding substrates. Each unique biosensor is a host cell having a receptor which signals production of a positive selectable marker and/or a negative selectable marker in response to the receptor being bound. Also provided is a method of identifying biosensor cells from a library that is specifically activated by a target, involving (a) contacting the library with the target substrate under positive selection conditions; (b) contacting the library with a control substrate under negative selection conditions; and (c) identifying biosensor cells which survive (a) and (b) as biosensor cells which are specifically activated by the target.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 28, 2019
    Applicant: Innovative Targeting Solutions Inc.
    Inventors: Craig Robin Pigott, Michael Lajos Gallo, Jaspal Singh Kang
  • SINGLE VARIABLE DOMAIN T-CELL RECEPTORS
    Publication number: 20190255186
    Abstract: There is provided a single variable domain T-cell receptor (svd-TCR) comprising a first TCR variable domain, the first TCR variable domain specifically binding to an epitope, that is not a superantigen, in the absence of a second TCR variable domain. Also provided are compositions and cells comprising the svd-TCR as well as methods of identifying the svd-TCR.
    Type: Application
    Filed: December 2, 2016
    Publication date: August 22, 2019
    Inventors: Michael Lajos GALLO, Jaspal Singh KANG, Craig Robin PIGOTT, Abby LIN, Falene CHAI
  • Directed switch-mediated DNA recombination
    Publication number: 20030190751
    Abstract: Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S1), and 2) a target locus minimally containing a promoter, a switch region (S2), and a target sequence.
    Type: Application
    Filed: April 3, 2002
    Publication date: October 9, 2003
    Inventors: Aya Jakobovits, Michael Lajos Gallo, Xiao-Ping Yang
  • Directed switch-mediated DNA recombination
    Patent number: 6395515
    Abstract: Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S1), and 2) a target locus minimally containing a promoter, a switch region (S2), and a target sequence.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: May 28, 2002
    Assignees: Abgenix, Inc., Japan Tobacco, Inc.
    Inventors: Aya Jakobovits, Michael Lajos Gallo, Xiao-Ping Yang
  • Directed switch-mediated DNA recombination
    Patent number: 5985615
    Abstract: Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S.sub.1), and 2) a target locus minimally containing a promoter, a switch region (S.sub.2), and a target sequence.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: November 16, 1999
    Assignees: Abgenix, Inc., Japan Tobacco Inc.
    Inventors: Aya Jakobovits, Michael Lajos Gallo, Xiao-Ping Yang