Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

Abstract: Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g. Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, progressive supranuclear palsy, Lewy body disease, Kennedy's disease, and other related conditions), from neuropathies resulting from neurological damage (chemotherapy-induced peripheral neuropathy, diabetic neuropathy, and related conditions) and from cognitive disorders caused by pharmacological intervention (e.g. chemotherapy induced cognitive disorder, also known as chemobrain).

Abstract: A pressure exchanger includes a rotor forming a duct from a first duct opening to a second duct opening. The pressure exchanger further includes a floating piston configured to move within the duct between the first duct opening and the second duct opening to prevent mixing of a first fluid and a second fluid while exchanging pressure between the first fluid and the second fluid. The pressure exchanger further includes a first adapter plate configured to prevent the floating piston from exiting the duct at the first duct opening and a second adapter plate configured to prevent the floating piston from exiting the duct at the second duct opening. The first adapter plate forms a first aperture that directs the first fluid to the first duct opening and the second adapter plate forms a second aperture that directs the second fluid to the second duct opening.

Abstract: A drug delivery system for injecting a medicament may include a housing defining a cavity, a container received within the cavity and configured to receive a medicament with the container including a closure, a valve assembly received within the cavity and including a piercing member configured to pierce the closure of the container, and a connector arrangement provided between the container and the valve assembly, the connector arrangement movable between a first, pre-use position maintaining sterility between the closure of the container and the valve assembly and a second, use position permitting fluid communication between the container and the valve assembly.

Abstract: A method for the liquefaction of hydrogen is provided. The can include the steps of: precooling a hydrogen feed stream in a precooling cold box having a heat exchanger disposed therein to form a cooled hydrogen stream, wherein the heat exchanger is configured to cool down the feed stream within the precooling cold box by indirect heat exchange between the hydrogen feed stream and a precooling refrigerant; and withdrawing the cooled hydrogen stream from the precooling cold box; introducing the cooled hydrogen stream to a plurality of liquefaction cold boxes, wherein the cooled hydrogen stream liquefies within the plurality of liquefaction cold boxes by indirect heat exchange against a liquefaction refrigerant to form a product hydrogen stream in each of the plurality of liquefaction cold boxes, wherein the product hydrogen stream is in liquid form or pseudo-liquid form wherein there are M total precooling cold boxes and N total liquefaction cold boxes, wherein M is less than N.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: According to an example aspect of the present invention, there is provided A process for making a cellulose fibre or film comprising the steps of dissolving pulp in an ionic liquid containing a cationic 1,5,7-triazabicyclo[4.4.0]dec-5-enium [TBDH]+ moiety and an anion selected from the group according to Formula a), Formula b) and Formula c), wherein each of R, R2, R3, R4, R5, R7, R8, R9 and R10 is H or an organyl radical and X? is selected from the group consisting of halides, pseudohalides, carboxylates, alkyl sulphite, alkyl sulphate, dialkylphosphite, dialkyl phosphate, dialkyl phosphonites and dialkyl phosphonates, to provide a spinning dope, extruding the spinning dope through a spinneret to form one or more filaments, and a step selected from the group consisting of spinning cellulose fibres from the solution, and extruding a cellulose film from the solution.

Abstract: A switch-mode power supply circuit includes a low-side switching transistor, a high-side switching transistor, a low-side current sensing circuit, and a gate driver circuit. The low-side current sensing circuit is coupled to the low-side switching transistor and is configured to sense a current flowing through the low-side switching transistor. The gate driver circuit is coupled to the low-side current sensing circuit and the high-side switching transistor. The gate driver circuit is configured to generate a signal having a first drive strength to switch the high-side switching transistor based on current flowing through the low-side switching transistor being less than a threshold current, and to generate a signal having a second drive strength to switch the high-side switching transistor based on current flowing through the low-side switching transistor being greater than the threshold current. The first drive strength is greater than the second drive strength.

Abstract: A valve system for a catheter, such as an aspiration catheter, is disclosed and includes a valve having a proximal end and a distal end. The distal end of the valve is coupled to the catheter. The valve has a flexible lumen in a first state that is constricted or twisted. The valve system is housed within a hub, where actuation of a button on the hub causes the proximal and distal ends of the valve to rotate relative to each other to put the lumen in a second state that is unconstricted or untwisted state.

Abstract: The present specification is directed towards catheter devices having expandable and collapsible lumens. Air or fluid is pumped into the catheter wall to cause it to expand. Alternatively, wires are embedded within the wall and a direction of flow of electrical current through the wires is modulated to enable the catheter device to be in the collapsed or expanded state. For example, a first wire is embedded within the wall and is helically wound along a length of the catheter device. A second wire is provided that can be removably positioned within the lumen. The direction of flow of electric current through the first and second wires is modulated to enable the catheter device to be in the collapsed or expanded state.

Abstract: Gas distribution apparatus to provide uniform flows of gases from a single source to multiple processing chambers are described. A regulator is positioned at an upstream end of a shared volume having a plurality of downstream ends. A flow controller is positioned at each downstream end of the shared volume, the flow controller comprising an orifice and a fast pulsing valve. Methods of using the gas distribution apparatus and calibrating the flow controllers are also described.

Abstract: A method for transmitting, during an electronic payment made by at least one user, at least one second identifier of the at least one user. The method is implemented by a transmitting device and includes: obtaining at least one first identifier of the at least one user from at least one electronic payment element of the at least one user, the at least one first identifier being used for the electronic payment; generating the at least one second identifier of the user, the second identifier comprising at least one datum and one portion of the at least one first identifier; and when the electronic payment has completed, transmitting the at least one second identifier to a device for managing at least one electronic proof of purchase.

Abstract: An electrical power converter unit (2) includes: a first connection interface (10) comprising two leads (12, 14) forming a DC input/output interface for connecting a first electrical device to the power converter unit, a three-phase rectifier power converter circuit (16) and a second connection interface (30) for connecting a second electrical device to the power converter unit. The second connection interface includes a switching unit (46) adapted to switch between:—a DC input/output mode, in which first, second and third arms of the power converter circuit (16) are electrically connected together, forming one DC input/output; and—an AC input/output mode, in which the arms are disconnected from each other, forming separate input/outputs for a three-phase AC voltage.

Abstract: An oil filter for a motor vehicle has a filter cartridge which is disposed in an oil filter housing of the oil filter. The filter cartridge has a channel for filtered oil which is surrounded at least regionally by a filter material in the radial direction. At least one through opening is formed in a wall of the channel. An emergence of filtered oil via the at least one through opening into a channel for the filtered oil provided on sides of the oil filter housing is preventable by bringing the filter cartridge into a first position. An inlet into the channel provided on sides of the oil filter housing fluidically connectable to the at least one through opening by bringing the filter cartridge into a second position in which the filter cartridge is shifted relative to the first position in an axial direction.

Abstract: A SOT device includes a bismuth antimony dopant element (BiSbE) alloy layer over a substrate. The BiSbE alloy layer is used as a topological insulator. The BiSbE alloy layer includes bismuth, antimony, AND a dopant element. The dopant element is a non-metallic dopant element, a metallic dopant element, and combinations thereof. Examples of metallic dopant elements include Ni, Co, Fe, CoFe, NiFe, NiCo, NiCu, CoCu, NiAg, CuAg, Cu, Al, Zn, Ag, Ga, In, or combinations thereof. Examples of non-metallic dopant elements include Si, P, Ge, or combinations thereof. The BiSbE alloy layer can include a plurality of BiSb lamellae layers and one or more dopant element lamellae layers. The BiSbE alloy layer has a (012) orientation.

Abstract: Facility layouts and configurations for an automated crop production system for controlled environment agriculture. In particular implementations, the core of the facility comprises a controlled growth environment and a central processing system. The controlled growth environment includes systems for exposing crops housed in modules, such as grow towers, to controlled environmental conditions. The central processing system may include various stations and functionality both for preparing crop-bearing modules to be inserted in the controlled growth environment, for harvesting crops from the crop-bearing modules after they have been extracted from the controlled growth environment, and for cleaning or washing crop-bearing modules for re-use. The controlled growth environment may include vertical farming structure having vertical grow towers and associated conveyance mechanisms for moving the vertical grow towers along one or more grow lines.

Abstract: The present specification is directed towards catheter devices having expandable and collapsible lumens. Air or fluid is pumped into the catheter wall to cause it to expand. Alternatively, wires are embedded within the wall and a direction of flow of electrical current through the wires is modulated to enable the catheter device to be in the collapsed or expanded state. For example, a first wire is embedded within the wall and is helically wound along a length of the catheter device. A second wire is provided that can be removably positioned within the lumen. The direction of flow of electric current through the first and second wires is modulated to enable the catheter device to be in the collapsed or expanded state.

Abstract: A vertical farming structure having vertical grow towers and associated conveyance mechanisms for moving the vertical grow towers through a controlled environment, while being exposed to controlled conditions, such as lighting, airflow, humidity and nutritional support. The present disclosure describes a reciprocating cam mechanism that provides a cost-efficient mechanism for conveying vertical grow towers in the controlled environment. The reciprocating cam mechanism can be arranged to increase the spacing of the grow towers as they are conveyed through the controlled environment to index the crops growing on the towers. The present disclosure also describes a tower shuttle mechanism that provides operational flexibility by decoupling the loading and unloading operations of the grow towers from the vertical farming structure and, therefore, allowing multiple grow towers to be extracted for harvesting in a batch process before loading new grow towers into the vertical farming structure in a separate process.

Abstract: A MRAM device includes a magnetic tunnel junction containing a reference layer having a fixed magnetization direction, a free layer, and a nonmagnetic tunnel barrier layer located between the reference layer and the free layer, a negative-magnetic-anisotropy assist layer having negative magnetic anisotropy that provides an in-plane magnetization within a plane that is perpendicular to the fixed magnetization direction, and a first nonmagnetic spacer layer located between the free layer and the negative-magnetic-anisotropy assist layer.

Abstract: The combined use of polyol esters and cationic polyelectrolytes as additives in cosurfactant-containing aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.