Abstract: A harvesting unit with a combine, having a user cab. A harvesting apparatus, advanced by the combine, has a frame and a harvesting assembly on the frame configured to process severed crop over a width between spaced sides of the frame. A fluid delivery system discharges pressurized fluid in discrete streams each directed to at least one of: a) facilitate severance of crop by the harvesting assembly; and b) facilitate advancement of severed crop rearwardly in relationship to the frame for further processing. A user can selectively vary at least one of: a) a volume of pressurized fluid; and b) a direction of pressurized fluid in the discrete streams. A control system has at least one actuator accessible and operable from outside of the cab through a user input to cause the at least one of the volume of pressurized fluid discharged, and direction of the pressurized fluid, in the discrete streams to be varied.

Abstract: The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe3+, and sulfosalicylic acid and from acetate, Fe3+, and salicylic acid.

Abstract: An extension assembly for a processed crop storage tank on a combine. A closure assembly for a top opening on the tank has at least one panel with one surface area that is exposed to bound a part of an exterior space above the storage space with the closure assembly open. The extension assembly has a first extension panel with a first surface with a first area and a connecting system through which the first extension panel is operatively connected to the combine. The first extension panel is changeable between a deployed position and a stored position. In the deployed position the first surface and one surface define a combined exposed surface area that is greater than the first area of the first surface. The combined surface area is exposed to confine processed crop in the exterior space with the closure assembly open.

Abstract: A method of forming a layered candle assembly includes positioning a candle core in a form. A layer of powdered wax is loaded into the form. The powdered wax layer has an outer region and an inner region. Mechanical force is applied to compress the outer region of the powdered wax layer and form an upper interface surface that is substantially non-horizontal. The outer perimeter of the interface surface is visible to an observer in the finished candle assembly. A liquefied fuel substance is poured over the top of the powdered wax layer to form a layer of solid wax. A wick may be added to at a desirable stage in the method of forming the layered candle assembly. The powdered wax and solid wax layers may each have a color or a combination of colors and/or a scent component or a combination of scent components.

Abstract: A method of forming a layered candle assembly includes positioning a candle core in a form. A layer of powdered wax is loaded into the form. The powdered wax layer has an outer region and an inner region. Mechanical force is applied to compress the outer region of the powdered wax layer and form an upper interface surface that is substantially non-horizontal. The outer perimeter of the interface surface is visible to an observer in the finished candle assembly. A liquefied fuel substance is poured over the top of the powdered wax layer to form a layer of solid wax. A wick may be added to at a desirable stage in the method of forming the layered candle assembly. The powdered wax and solid wax layers may each have a color or a combination of colors and/or a scent component or a combination of scent components.

Abstract: The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe3+, and sulfosalicylic acid and from acetate, Fe3+, and salicylic acid.

Abstract: A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): Each of A, N*, X, Y, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.

Abstract: A method of treating a disorder such as epilepsy, multiple sclerosis, glaucoma and uveitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia, or trigeminal autonomic cephalalgias. The method includes administering to a subject in need thereof substituted 1,2,4-triazine compounds of formula (I): Each of A, N*, X, Y, Z, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.

Abstract: Provided herein are compositions and methods for eliciting an immune response against Porphyromonas gingivalis. The compositions and methods relate to P. gingivalis polypeptides and fragments and variants thereof and the corresponding polynucleotides which are useful in the diagnosis, prevention and therapy of P. gingivalis infections (e.g. periodontitis). Antibodies against the polypeptides and compositions and methods including these antibodies are also disclosed. The disclosure also describes methods for the detection, prevention and treatment of P. gingivalis infection (e.g. periodontitis).

Abstract: A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.

Abstract: A cryogen cooling system to cool a superconducting magnet is disclosed herein utilizing embedded vertical tubing with a large heat exchanging surface area. The tubing encompasses the magnet which is further surrounded by a 4 Kelvin thermal shield for extended ride-through. In one embodiment, the system is a hyperpolarizer having an internal high-pressure gas storage for quench gas and to initiate cool-down. Aspects of the invention utilize a minimal volume of pressurized gas, for example, four (4) liters of pressurized gaseous helium in a 150 mL liquid helium system. As such, the prior vent stack has been removed, along with the helium vessel and quench paths/ducts. The method of using the system is further simplified during ramping while the cool-down process utilizing liquids supplied from external dewars has been eliminated. Significant advantages include reducing the helium volume (and cost associated therewith) and allowing for a hermetically sealed vacuum system that is leak-proof.

Abstract: A thermal switching device is presented. The thermal switching device includes a plurality of serpentine capillaries having a first end and a second end, where the first end is configured to be operatively coupled to a heating unit and the second end is configured to be operatively coupled to a cooling unit, and where the plurality of serpentine capillaries is configured to transfer heat from the heating unit to the cooling unit by circulating a working fluid in the plurality of serpentine capillaries.

Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system, or a pharmaceutically acceptable salt or solvate thereof.

Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system, or a pharmaceutically acceptable salt or solvate thereof.

Abstract: Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.

Abstract: A method of forming a layered candle assembly includes positioning a candle core in a form. A layer of powdered wax is loaded into the form. The powdered wax layer has an outer region and an inner region. Mechanical force is applied to compress the outer region of the powdered wax layer and form an upper interface surface that is substantially non-horizontal. The outer perimeter of the interface surface is visible to an observer in the finished candle assembly. A liquefied fuel substance is poured over the top of the powdered wax layer to form a layer of solid wax. A wick may be added to at a desirable stage in the method of forming the layered candle assembly. The powdered wax and solid wax layers may each have a color or a combination of colors and/or a scent component or a combination of scent components.

Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula (I): in which z is a single bond or an optionally substituted linking group, R1 is a halo-alkyl group; and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system; or a salt thereof.

Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ?NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof.

Abstract: A method of treating a disorder. The method includes administering to a subject in need thereof a compound of formula (I): Each of A, N*, X, Y, Z, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.

Abstract: A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.