Patents by Inventor Michael Lebl

Michael Lebl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200348307
    Abstract: The present disclosure relates to methods and kits for analysis of polypeptides. In some embodiments, the present methods and kits employ barcoding and nucleic acid encoding of molecular recognition events, and/or detectable labels.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 5, 2020
    Applicant: Encodia, Inc.
    Inventors: John M. BEIERLE, Robert C. JAMES, Luca MONFREGOLA, Kevin GUNDERSON, Michael LEBL, Lei SHI
  • Publication number: 20110105366
    Abstract: The invention is directed to a method of fabricating a microarray. The method includes: (a) providing a substrate having at least two layers of different chemical reactivity, wherein a well in an outer layer exposes an inner layer; (b) contacting the substrate with a first reagent specifically reactive with the outer layer to produce a first modified layer; (c) contacting the substrate with a second reagent specifically reactive with the inner layer of the substrate to produce a modified inner layer, wherein the modified inner layer has a higher affinity for a biopolymer than the modified outer layer, and (d) depositing the biopolymer onto the modified inner layer within the well, wherein the higher affinity of the modified inner layer facilitates localization of the biopolymer onto the well. Methods of fabricating a microarray which include polishing a substrate or functionalizing a plurality of features with a reactive reagent also are provided.
    Type: Application
    Filed: June 18, 2008
    Publication date: May 5, 2011
    Applicant: ILLUMINA, INC.
    Inventors: Michael Lebl, David L. Heiner, Chanfeng Zhao, David Barker
  • Patent number: 6045755
    Abstract: In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: April 4, 2000
    Assignee: Trega Biosciences,, Inc.
    Inventors: Michael Lebl, Vit Pokorny, Viktor Krchnak