Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: A clip is provided for managing access through tissue. The clip is placed around an opening in tissue, although the opening may alternatively be formed after the clip is deployed. The clip can expand when medical devices are introduced through the clip and through the opening. When the medical devices are removed, the clip closed automatically to substantially close the opening.

Abstract: A clip is provided for managing access through tissue. The clip is placed around an opening in tissue, although the opening may alternatively be formed after the clip is deployed. The clip can expand when medical devices are introduced through the clip and through the opening. When the medical devices are removed, the clip closed automatically to substantially close the opening.

Abstract: A clip is provided for managing access through tissue. The clip is placed around an opening in tissue, although the opening may alternatively be formed after the clip is deployed. The clip can expand when medical devices are introduced through the clip and through the opening. When the medical devices are removed, the clip closed automatically to substantially close the opening.

Abstract: Systems and methods for uniformly expanding and heat setting medical devices. One method can include expanding a medical device by advancing the medical device over a preheated expander, the medical device being uniformly expanded as the medical device is advanced over the preheated expander; and heat setting the expanded medical device while the medical device is positioned over the expander, the preheated expander being maintained at a predetermined heat-setting temperature. The preheated expander can be positioned within a thermal chamber that maintains the preheated expander at the predetermined heat-setting temperature. The medical device can be physically separated from the preheated expander when the medical device is positioned over the expander and can be comprised of a shape-memory material. The preheated expander can remain heated during the expansion and heat setting of a plurality of medical devices.

Abstract: A method for manufacturing a medical device. The method can include forming a medical device from a tube having a first diameter; uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; and heat setting the expanded medical device at the second diameter while the medical device is positioned on the expander.

Abstract: A clip is provided for managing access through tissue. The clip is placed around an opening in tissue, although the opening may alternatively be formed after the clip is deployed. The clip can expand when medical devices are introduced through the clip and through the opening. When the medical devices are removed, the clip closed automatically to substantially close the opening.

Abstract: A system and method for manufacturing a medical device. The system can include a thermal chamber and an expander at least partially positioned within the thermal chamber. The expander can be configured to uniformly expand a medical device as the medical device is advanced over the heated expander and heat set the expanded medical device while the medical device is positioned on the heated expander. The method can include forming a medical device from a tube having a first diameter; uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; and heat setting the expanded medical device at the second diameter while the medical device is positioned on the expander.

Abstract: Systems and methods for uniformly expanding and heat setting medical devices. One method can include expanding a medical device by advancing the medical device over a preheated expander, the medical device being uniformly expanded as the medical device is advanced over the preheated expander; and heat setting the expanded medical device while the medical device is positioned over the expander, the preheated expander being maintained at a predetermined heat-setting temperature. The preheated expander can be positioned within a thermal chamber that maintains the preheated expander at the predetermined heat-setting temperature. The medical device can be physically separated from the preheated expander when the medical device is positioned over the expander and can be comprised of a shape-memory material. The preheated expander can remain heated during the expansion and heat setting of a plurality of medical devices.