Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: An inspection apparatus includes a specimen stage configured to retain a specimen, at least three imaging devices arranged in a triangular array positioned above the specimen stage, each of the at least three imaging devices configured to capture an image of the specimen, one or more sets of lights positioned between the specimen stage and the at least three imaging devices, and a control system in communication with the at least three imaging devices.

Abstract: Fibrous structures comprising spunbond filaments and solid additives and methods for making such fibrous structures are provided.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: A multiplexer includes a charging circuit; a plurality of sampling switches receiving a plurality of input signals; and a plurality of boosting circuits connected between the sampling switches and the charging circuit and sharing the charging circuit. First and second charging switches of the charging circuit are controlled by a first clock signal. Each of the boosting circuits includes a first boosting switch connected to a first node of the charging circuit and a gate of one of the sampling switches, a second boosting switch connected between a second node of the charging circuit and the one sampling switch, and a level shifter configured to control the first boosting switch and the second boosting switch in response to a second clock signal and a selection signal.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. Microservices on the transaction exchange platform may interact with the transaction objects based on configured workflows associated with the transactions. Processing on the transaction exchange platform may facilitate clearing and settlement of transactions. Some aspects may provide for dynamic and flexible reconfiguration of workflows and/or microservices. Other aspects may provide for data snapshots and workflow tracking, allowing for monitoring, quality control, and auditability of transactions on the transaction exchange platform.

Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

Abstract: Devices for removing implanted objects from body vessels are provided. A device includes a sheath assembly having a cutting tip. The cutting tip includes a cutting surface that is adapted to cut tissue coupled to an implanted object as the cutting tip rotates. The sheath assembly further includes an outer shield carried outside of the cutting tip. The outer shield includes a distal opening, and the outer shield is translatable relative to the cutting tip from a first position to a second position and vice versa. In the first position the cutting surface of the cutting tip is disposed within the outer shield, and in the second position the cutting tip extends through the distal opening and the cutting surface is at least partially disposed outside of the outer shield.

Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide customized feedback content during a meditation experience. For example, an example process may include obtaining physiological data via one or more sensors, determining that an attentive state based on the physiological data, customizing feedback content based on a user attribute to change the attentive state during the meditation mode, and providing the customized feedback content during the meditation mode after a delay time based on the user attribute.

Abstract: The presently disclosed subject matter relates to multi-material electrical contacts, and methods of making multi-material electrical contact comprising a functionally graded monolithic structure, having a first metal and a second metal, an amount of the second metal as compared to an amount of the first metal increases with distance in the structure from a first surface to a second opposing surface of the structure such that the second metal content increases continuously or incrementally throughout the height of the electrical contact.

Abstract: According to various embodiments, a direct magnetic gradiometer having intrinsic subtraction of rotation signals from two oppositely polarized atomic ensembles within a single multi-pass cell is disclosed. The gradiometer includes three convex spherical mirrors aligned in a V-shape geometry. The three convex spherical mirrors include a front mirror and two back mirrors. The gradiometer further includes a probe laser beam. The laser beam is configured to be initially focused at a near-zero angle into a hole at a center of the front mirror such that the laser beam expands at the back mirrors and nearly overlaps with itself while undergoing multiple reflections between the front and back mirrors. The laser beam is further configured to be refocused to the front mirror at different spots in a number equal to half of total beam passes before exiting.

Abstract: An automated system and method for assisting in decision making for the treatment of stroke patients is provided, and specifically for assisting a physician whether the patient should be administered a drug or transferred to another hospital to undergo an endovascular thrombectomy procedure. A variety of factors are input into the system with limited human intervention and a tool automatically determines the probability of whether the patient will have a better outcome if transferred or not. The factors include clinical factors, imaging factors and time to transfer factors. The tool includes processes for automatically determining several imaging factors, including the determination of clot length, collateral blood flow, the presence of forward blood flow within and around the clot, and the clot permeability. The tool has capability to continuously update the treatment protocol and other output results using current clinical, health system or other relevant information or feedback.

Abstract: A filling method and process for a flower cartridge for use with a portable electronic heating device for the smokeless delivery of active ingredients and volatile compounds released from heating natural consumables such as plant matter is disclosed. Through grinding, vibration, and tamping, a number of cartridges are filled with natural consumables. Compressive forces applied via tamping, coupled with a constriction or obstruction within the cartridge, form a porous plug to which air flows freely but the consumables remain in place. The filling process minimizes oxidation and preserves the shelf life of the flower cartridge.

Abstract: A method and apparatus of limiting power of a boiling water nuclear reactor system includes a reactor pressure vessel, a reactor core disposed in the reactor pressure vessel, a core shroud surrounding the reactor core, a downcomer region disposed between an inner surface of the reactor pressure vessel and the core shroud, a steam line connected to an upper end of the reactor pressure vessel and a condenser system that receives steam from the reactor pressure vessel. A portion of the condenser system condensate is returned to the reactor pressure vessel of the boiling water reactor inside the core barrel above the core rather than into the downcomer. Returning the condensate in this way increases the effectiveness of an isolation condenser system or if the condensate is a portion of the feedwater from the main condenser it provides an effective means to regulate core flow and core power.

Abstract: A system is disclosed herein. The system includes a splitter board. The splitter board includes a microprocessor, a converter, and a bypass relay. The converter includes analog-to-digital circuitry and digital-to-analog circuitry. The bypass relay is configurable between a first state and a second state. In the first state, the bypass relay is configured to direct an input signal to the converter. The converter converts the input signal to a converted input signal and splits the converted input signal into a first portion and a second portion. The first portion is directed to the microprocessor. The second portion is directed to an output port of the splitter board for downstream processes. In the second state, the bypass relay is configured to cause the input signal to bypass the converter. The bypass relay directs the input signal to the output port of the splitter board for the downstream processes.

Abstract: A watertight electrical connection system to flat-wire conductors of a flexible circuit is described including a watertight electrical connector that houses connector terminals within a cavity. A contact surface of the watertight electrical connector is configured to mate with a connection area on a surface of the flexible circuit. The connection area is of variable thickness. A seal surrounds an opening to the cavity to form a watertight connection between the connector terminals and one or more of the flat-wire conductors within the connection area on the surface of the flexible circuit. A retainer fits over the flexible circuit and onto the watertight electrical connector to compress the seal and form the watertight connection between the surface of the flexible circuit and the contact surface, which is of variable thickness.

Abstract: An exposed secondary showerhead system configured to be supported by a conventional shower enclosure. The illustrative showerhead system includes an overhead conduit fluidly coupled to a conventional shower inlet pipe and to at least one showerhead.