Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.

Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.

Abstract: Polymer-cargo-complexes including cross-linked copolymers and cargo molecules bound to the copolymers by electrostatic interactions. The non-medical use thereof for transfection and to a kit including such polymer-cargo-complexes. The polymer-cargo-complexes for use in therapy, in particular for use in gene therapy or peptide/protein drug delivery. A method of preparing the polymer-cargo-complexes. A kit for preparing a polymer-cargo-complex of the invention.

Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.

Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.

Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.

Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.

Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.

Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.

Abstract: The subject of this application is the use of film-forming polyurethanes that are used in hair care agents or mixtures of these polyurethanes with other polymers in pharmaceutical preparations for dermal or transdermal administration of active ingredients, as well as patches and pharmaceutical preparations that contain these hair care polyurethanes.

Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.

Abstract: At least two devices are provided that can each form part of a system to inductively exchange power and data. One device is capable of inductively transmitting a power signal to a second device, and to receive feedback from the second device in order to regulate the power signal.

Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.

Abstract: An inductive signal interface comprises a coil assembly including one or more inductive coils, a bridge circuit including a plurality of switches, and control circuitry. The control circuitry is configured to individually operate the plurality of switches to enable the inductive signal interface to dynamically switch between a power-transmit mode and a power receive mode.

Abstract: Embodiments described herein include a computing device that is capable of inductive signal transfer with other computing devices. Such computing devices are provided a shield that protects the device and other components from electromagnetic interference and unwanted electrical affects resulting from the inductive signal transfer.

Abstract: An inductive signal interface comprises a coil assembly including one or more inductive coils, a bridge circuit including a plurality of switches, and control circuitry. The control circuitry is configured to individually operate the plurality of switches to enable the inductive signal interface to dynamically switch between a power-transmit mode and a power receive mode.

Abstract: At least two devices are provided that can each form part of a system to inductively exchange power and data. One device is capable of inductively transmitting a power signal to a second device, and to receive feedback from the second device in order to regulate the power signal.

Abstract: Embodiments described herein include a computing device that is capable of inductive signal transfer with other computing devices. Such computing devices are provided a shield that protects the device and other components from electromagnetic interference and unwanted electrical affects resulting from the inductive signal transfer.

Abstract: This invention relates to methods and compositions for increasing the bioavailability of pharmaceutical or lipophilic compounds. The invention further relates of methods of administering the compounds and compositions of the present invention to a human or animal.

Abstract: Compounds and compositions are disclosed for increasing the bioavailability of lipophilic drugs, and more specifically, to solubilizing lipophilic drugs using bioenhancers that cause no efflux inhibition or a desired degree of efflux inhibition. Methods of making and using such compositions are also disclosed.