Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Antisense oligonucleotides (ASOs) are provided which are capable of modulating splicing by preventing inclusion of an UNC13A cryptic exon into an UNC13A mature mRNA. Such ASOs may be used as a medicament, for example, to treat neurodegenerative disorders, particularly those associated with TDP-43 pathology.

Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.

Abstract: Apparatus for providing breathing assistance, the apparatus including a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user, two second openings provided in the oral cavity to allow air flow into and out of a posterior region of the oral cavity and two channels, each channel connecting a respective second opening to the at least one first opening and each channel passing at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway for the user, the airway at least partially bypassing the nasal passage and acting to replicate a healthy nasal passage and pharyngeal space.

Abstract: A radio-frequency excited carbon dioxide (CO2) or carbon monoxide (CO) gas laser includes two electrodes, which have passivated surfaces, within a sealed housing. Features in a ceramic slab or a ceramic cylinder located between the electrodes define a gain volume. Surfaces of the ceramic slab or the ceramic cylinder are separated from the passivated surfaces of the electrodes by small gaps to prevent abrasion thereof. Reducing compressive forces that secure these components within the housing further reduces abrasion, thereby extending the operational lifetime of the gas laser.

Abstract: A radio-frequency excited carbon dioxide (CO2) or carbon monoxide (CO) gas laser includes two electrodes, which have passivated surfaces, within a sealed housing. Features in a ceramic slab or a ceramic cylinder located between the electrodes define a gain volume. Surfaces of the ceramic slab or the ceramic cylinder are separated from the passivated surfaces of the electrodes by small gaps to prevent abrasion thereof. Reducing compressive forces that secure these components within the housing further reduces abrasion, thereby extending the operational lifetime of the gas laser.

Abstract: A frequency translating bi-directional amplifier (10) for extending radio coverage for digital mobile radio communication devices (200) on a trunked network using a digital modulation scheme, comprising: a field programmable gate array (FPGA) with local controller (CPU) and firmware (22) configured to analyse control channel messages of a downlink control channel and modify the control channel messages of the downlink control channel that contain traffic channel information; and an antenna (12) to transmit the modified control channel messages to the digital mobile radio communication devices (200) in order to change an operating frequency of the digital mobile radio communication devices (200) to use a predetermined set of frequencies that are repeatable by the bi-directional amplifier (10); wherein the operating frequency between the digital mobile radio communication devices (200) and the bi-directional amplifier (10) is different to an operating frequency between a donor base station (300) and the bi-dire

Abstract: A breathing assistance apparatus including a body shaped to be at least partially positioned within the oral cavity of a user, the body including: a bite configured to receive teeth of the user in use; an extra-oral opening that extends between lips of the user; an intra-oral opening provided in the oral cavity to allow airflow into and/or out of a posterior region of the oral cavity; and, at least one airway wall configured to define in combination with the bite an enclosed airway extending between the extra-oral and intra-oral openings.

Abstract: Apparatus for providing breathing assistance, the apparatus including a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user, two second openings provided in the oral cavity to allow air flow into and out of a posterior region of the oral cavity and two channels, each channel connecting a respective second opening to the at least one first opening and each channel passing at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway for the user, the airway at least partially bypassing the nasal passage and acting to replicate a healthy nasal passage and pharyngeal space.

Abstract: An apparatus is provided for breathing assistance that includes a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user. Two second openings are provided in the oral cavity to allow air flow into and out of a posterior region of the oral cavity and two channels, each channel connecting a respective second opening to the at least one first opening and each channel passing at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway for the user. The airway at least partially bypasses the nasal passage and acts to replicate a healthy nasal passage and pharyngeal space.

Abstract: A depository system operates in response to data bearing records. Information regarding planned future deposits is recorded, at least one record visible appearance feature is stored or generated, and data corresponding to the at least one record appearance feature is stored in associated relation with deposit data. The at least one record appearance feature is made visible on a deposit item. The deposit item is subsequently presented to a depository that includes an image sensor. The image sensor operates to read the at least one record appearance feature. At least one controller in the depository causes a determination to be made that at least one record appearance feature corresponds to a pre-registered deposit and such determination enables the deposit item to be received in the depository.

Abstract: An apparatus for providing breathing assistance includes first and second bodies configured to be positioned within an oral cavity of a user. Each of the first and second bodies includes a recess configured to receive a respective set of teeth of a user. An adjustable mounting is configured to interconnect the first and second bodies to thereby allow a relative position of the first and second bodies to be adjusted.

Abstract: A frequency translating bi-directional amplifier (10) for extending radio coverage for digital mobile radio communication devices (200) on a trunked network using a digital modulation scheme, comprising: a field programmable gate array (FPGA) with local controller (CPU) and firmware (22) configured to analyse control channel messages of a downlink control channel and modify the control channel messages of the downlink control channel that contain traffic channel information; and an antenna (12) to transmit the modified control channel messages to the digital mobile radio communication devices (200) in order to change an operating frequency of the digital mobile radio communication devices (200) to use a predetermined set of frequencies that are repeatable by the bi-directional amplifier (10); wherein the operating frequency between the digital mobile radio communication devices (200) and the bi-directional amplifier (10) is different to an operating frequency between a donor base station (300) and the bi-dire

Abstract: A depository system operates in response to data bearing records. Information regarding planned future deposits is recorded, at least one record visible appearance feature is stored or generated, and data corresponding to the at least one record appearance feature is stored in associated relation with deposit data. The at least one record appearance feature is made visible on a deposit item. The deposit item is subsequently presented to a depository that includes an image sensor. The image sensor operates to read the at least one record appearance feature. At least one controller in the depository causes a determination to be made that at least one record appearance feature corresponds to a pre-registered deposit and such determination enables the deposit item to be received in the depository.

Abstract: An apparatus for providing breathing assistance includes a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user. Two second openings are provided in the oral cavity to allow air flow into and out of a posterior region thereof. Two channels each connect a respective second opening to the at least one first opening. Each channel passes at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway at least partially bypassing the nasal passage to act to replicate a healthy nasal passage and pharyngeal space. A tongue retaining portion includes a cavity for receiving a portion of a tongue, the tongue retaining portion configured to retain the tongue in an extended position to project at least partially between the teeth.

Abstract: A depository system operates in response to data bearing records. Information regarding planned future deposits is recorded, at least one record visible appearance feature is stored or generated, and data corresponding to the at least one record appearance feature is stored in associated relation with deposit data. The at least one record appearance feature is made visible on a deposit item. The deposit item is subsequently presented to a depository that includes an image sensor. The image sensor operates to read the at least one record appearance feature. At least one controller in the depository causes a determination to be made that at least one record appearance feature corresponds to a pre-registered deposit and such determination enables the deposit item to be received in the depository.

Abstract: A depository system operates in response to data bearing records. Information regarding planned future deposits is recorded, at least one record visible appearance feature is stored or generated, and data corresponding to the at least one record appearance feature is stored in associated relation with deposit data. The at least one record appearance feature is made visible on a deposit item. The deposit item is subsequently presented to a depository that includes an image sensor. The image sensor operates to read the at least one record appearance feature. At least one controller in the depository causes a determination to be made that at least one record appearance feature corresponds to a pre-registered deposit and such determination enables the deposit item to be received in the depository.

Abstract: An apparatus is provided for breathing assistance that includes a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user. Two second openings are provided in the oral cavity to allow air flow into and out of a posterior region of the oral cavity and two channels, each channel connecting a respective second opening to the at least one first opening and each channel passing at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway for the user. The airway at least partially bypasses the nasal passage and acts to replicate a healthy nasal passage and pharyngeal space.