Abstract: Disclosed are methods for exploiting memory properties of biological systems such as gene regulatory networks (GNRs). The disclosed methods may be utilized in order to treat diseases and disorders and in order to promote health.

Abstract: In one embodiment, a medical system includes a catheter interface comprising electrode lines configured to be electrically connected to respective electrodes of a catheter, and a signal generation apparatus configured to generate signal pulses, each of the signal pulses comprising a carrier frequency and having a non-rectangular signal envelope, the signal generation apparatus being configured to time multiplex the signal pulses among the electrode lines.

Abstract: A method of identifying a subject having Kawasaki disease (KD), which includes discriminating the subject from a subject having another condition, for example other infectious and inflammatory conditions, such as those that present similar symptoms to KD. Also provided is a minimal gene signature employed in the method, as well as primers, probes and gene chips for use in the method.

Abstract: Aspects of the present application relate to systems and methods for automated web-based filter tuning. The method can include receiving information characterizing a plurality of attributes of a web server and normalizing the received information. The method can include identifying a set of relevant tags to the web server via comparison of the normalized received information to data contained in a tag database, and forming a set of signatures relevant to the web server based at least in part on the set of relevant tags. The method can include receiving an administrator selection of at least some of the set of signatures, enabling the selected at least some of the set of signatures for filtering of received web requests.

Abstract: An apparatus for stimulation of tissue regeneration at a site in tissue of a subject, the apparatus comprising: an outer sleeve having a tissue receiving end, a pressing member receiving end opposite the tissue receiving end, and an internal chamber configured for receiving the tissue; a pressing member; an inner sleeve disposed within the outer sleeve, the inner sleeve having an end for receiving the site of the tissue for regeneration, an engagement receiving end, opposite the end for receiving the site of the tissue for regeneration, for engaging the pressing member, and an internal chamber configured for receiving the site of the tissue for regeneration, wherein the internal chamber of the inner sleeve comprises a therapeutic composition, wherein the therapeutic composition comprises a growth factor, wherein the growth factor comprises (i) bone morphogenetic protein 2 (BMP2), or (ii) a bone morphogenetic protein and a vascular endothelial growth factor (VEGF).

Abstract: An apparatus includes two or more medical systems and a low impedance path. The two or more medical systems have respective electrical outputs and respective separate isolation grounds each isolated from power lines and from earth ground, wherein the two or more medical systems are electrically coupled one with the other via the patient. The low impedance path connects the separate isolation grounds of the medical systems to one another, causing one or more leakage currents to flow via the low impedance path instead of via the patient.

Abstract: An assistive device for a metered dose inhaler decreases the force required to operate the inhaler. The assistive device has a body with a passage for receiving a replaceable conventional metered dose inhaler assembly that has a canister and a transverse mouthpiece with an axis of the canister aligning approximately with that of the passage. At least two symmetrically arranged levers extend in a direction away from the body and parallel to an axis thereof. A proximal end of each lever is attached to the body such that the free opposite ends of the levers may be moved towards and away from each other. An inwardly directed cam surface on each of the lever exerts a force on an end of the canister in use to move the canister longitudinally to cause a dose of medicament to be dispensed from the canister. An optional dose counter may form part of the device.

Abstract: A power line interference (PLI) suppression method includes receiving an input analog signal superimposed with PLI, and digitally estimating one or more harmonics of the PLI in real-time. Responsively to the one or more digitally estimated harmonics, one or more analog harmonic waveforms are outputted, that match the respective one or more harmonics of the PLI. The input analog signal and the one or more analog harmonic waveforms are received, and the superimposed PLI in the input analog signal is suppressed using the one or more analog harmonic waveforms. An analog output signal is outputted, that corresponds to the input analog signal having the suppressed PLI.

Abstract: Various systems and methods for making biological robots are disclosed. An example system can include a well plate with a receptacle, a robotic assembly configured to form a biological robot in the receptacle by dispensing biological material into the receptacle, an insert positioned to interact with the receptacle including one or more components configured to stimulate to the biological robot, and a camera system configured to monitor the biological robot in the receptacle. The example system can further include a computing system configured to receive an input from a user indicative of a desired behavior of the biological robot, apply the user input as input to an artificial intelligence model, identify a stimulus for providing to the biological robot, and cause the insert to provide the stimulus to the biological robot.

Abstract: A method of forming a security device includes: a holographic image layer, diffusion element, and barrier layer. A region of the barrier layer includes a heat-transformable material. The method further includes selectively applying heat at a plurality of positions within the region of the barrier layer, in accordance with a predetermined pattern, so as to modify the heat-transformable material such that the region of the barrier layer is selectively rendered passable to the diffusible substance at each of the plurality of positions, thereby permitting diffusion of the diffusible substance between the regions of the diffusion element and the holographic image layer such that, at a plurality of positions within the region of the holographic image layer and corresponding to the predetermined pattern, the volume hologram is dimensionally modified so as to become viewable in a second observable colour, different from the first observable colour.

Abstract: Techniques are provided herein for increased processing efficiencies in the end-to-end creative offering process. Namely, a uniform ingest process for creative assets yields uniformity across creative providers. Further, centralized ingest of campaign information and creative assets bridges independent systems involved in the creative offering process. In this manner, creative processing tasks, from creative ingest and quality control, to activation with the ad decisioning service and active creative/campaign reporting may be facilitated by a uniform central source of truth. This may result in increased processing efficiencies and reduced processing delay in offering creative assets, which, in turn, may increase revenues generated from the offered creative assets.

Abstract: Disclosed are engineered multicellular organisms. The disclosed organisms comprise an aggregate of ciliated cells, and the organisms move when the ciliated cells are actuated. The engineered multicellular organisms also are capable of kinematic self-replication. The engineered multicellular organisms are capable of moving a plurality of dissociated ciliated cells into piles of ciliated cells which form a multicellular organism comprising an aggregate of ciliated cells which moves when the ciliated cells are actuated. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms.

Abstract: A method of identifying a subject having Kawasaki disease (KD), which includes discriminating the subject from a subject having another condition, for example other infectious and inflammatory conditions, such as those that present similar symptoms to KD. Also provided is a minimal gene signature employed in the method, as well as primers, probes and gene chips for use in the method.

Abstract: Disclosed are methods and compositions for treating cell proliferative diseases and disorders including cancers such as glioblastoma. The disclosed methods and compositions may utilize or comprise one or more modulators of the bioelectric state of cells, such as, one or more potassium channel activators; a sodium channel inhibitor combined with an mTOR inhibitor; a sodium channel inhibitor combined with a proton pump inhibitor; a calcium channel inhibitor combined with an mTOR inhibitor; a proton pump inhibitor combined with an alkylating agent; or a combination of at least one potassium channel activator and one or more of an alkylating agent, calcium channel inhibitor, corticosteroid, mTOR inhibitor, proton pump inhibitor, and/or sodium channel inhibitor.

Abstract: Disclosed are engineered multicellular organisms. The disclosed organisms comprise an aggregate of ciliated cells, and the organisms move when the ciliated cells are actuated. The engineered multicellular organisms also are capable of kinematic self-replication. The engineered multicellular organisms are capable of moving a plurality of dissociated ciliated cells into piles of ciliated cells which form a multicellular organism comprising an aggregate of ciliated cells which moves when the ciliated cells are actuated. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms.

Abstract: The present disclosure provides compositions and methods for treating neurodevelopmental disorders, such as Rett syndrome and cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder.

Abstract: An annuloplasty implant is assembled at a valve of a heart of a subject by (1) transfemorally delivering, to the heart, a first subunit of the implant; and securing the first subunit to tissue of the heart by driving, into the tissue, a first anchor connected to the subunit by a flexible strip; and (2) subsequently, for multiple successive subunits of the implant, iteratively: (a) transfemorally delivering, to the heart, the successive subunit; and (b) securing the successive subunit to the tissue of the heart by driving, into the tissue, a respective anchor connected to the successive subunit by a respective flexible strip. The annuloplasty implant is subsequently contracted to contract the valve. Other embodiments are also described.

Abstract: An implant, disposed within a catheter, comprises a ring, anchors, and adjustment elements. The ring comprises struts arranged in a pattern of alternating peaks and troughs. Each strut has a first end-portion and a second end-portion. Each peak is defined by convergence of adjacent first end-portions disposed at an angle with respect to each other, and each trough is defined by convergence of adjacent second end-portions. Each of the anchors has a longitudinal axis, is coupled to the ring at a respective trough, and is configured to be driven along the longitudinal axis with respect to the trough and into tissue of the heart. Each of the adjustment elements is configured to adjust an angular disposition between a respective pair of the struts. A first adjustment element is coupled to its pair, and a second adjustment element is coupled to its pair distal to the first adjustment element.

Abstract: Described embodiments include an apparatus that includes an expandable structure, configured for insertion into a body of a subject, and a plurality of conducting elements coupled to the expandable structure. Each of the conducting elements comprises a respective coil and has an insulated portion that is electrically insulated from tissue of the subject, and an uninsulated portion configured to exchange signals with the tissue, while in contact with the tissue. Other embodiments are also described.