Abstract: An apparatus includes two or more medical systems and a low impedance path. The two or more medical systems have respective electrical outputs and respective separate isolation grounds each isolated from power lines and from earth ground, wherein the two or more medical systems are electrically coupled one with the other via the patient. The low impedance path connects the separate isolation grounds of the medical systems to one another, causing one or more leakage currents to flow via the low impedance path instead of via the patient.

Abstract: A power line interference (PLI) suppression method includes receiving an input analog signal superimposed with PLI, and digitally estimating one or more harmonics of the PLI in real-time. Responsively to the one or more digitally estimated harmonics, one or more analog harmonic waveforms are outputted, that match the respective one or more harmonics of the PLI. The input analog signal and the one or more analog harmonic waveforms are received, and the superimposed PLI in the input analog signal is suppressed using the one or more analog harmonic waveforms. An analog output signal is outputted, that corresponds to the input analog signal having the suppressed PLI.

Abstract: Described herein are pharmaceutical formulations comprising multi-specific binding proteins that bind to NKG2D, CD16, and epidermal growth factor receptor (EGFR); and therapeutic uses of the multi-specific binding proteins and pharmaceutical formulations thereof for treating a disease, for example, cancer, in a patient in need thereof.

Abstract: Disclosed are engineered multicellular organisms. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.

Abstract: A system and method for cloud native discovery and protection. The method includes discovering instances of a plurality of cloud assets in a cloud native environment based on a plurality of application programming interface (API) endpoints in the cloud native environment, wherein the plurality of API endpoints is identified based on cloud credentials for each of the plurality of cloud assets; determining at least one cloud asset instance that lacks active security protection based on a configuration of at least one entity deployed in the cloud native environment; and reconfiguring at least a portion of the cloud native environment with respect to the at least one cloud asset instance that lacks active security protection.

Abstract: Methods and apparatuses for scheduling tasks with a job scheduler are disclosed. In one embodiment, the method comprises: tracking a number of active tasks for each key of a plurality of keys; writing, by a scheduler, a query to identify a next scheduled task among a plurality of scheduled tasks ordered by time in a task queue, the query having an index that excludes tasks associated with a list of one or more keys of the plurality of keys that have a count of active tasks greater than a first limit associated with each key; querying, by a scheduler, the task queue using the query to identify the next scheduled task among the plurality of scheduled tasks, the next scheduled task being associated with a key not excluded by the query; and executing the next scheduled task.

Abstract: Systems, devices and methods for performing medical procedures in the intestine of a patient are provided. A medical device for performing a treatment and/or a diagnostic procedure can include an elongate shaft assembly comprising at least a shaft assembly first section comprising a distal section of the shaft assembly, and a shaft assembly second section proximal to the first section, and a functional assembly positioned on the shaft assembly first section. Additional sections of the shaft assembly can be included, and each section can comprise a different construction, such as to achieve a different stiffness as described herein. Variable stiffness along the length of the shaft assembly can be provided to aid in translation of the device through the patient's GI tract (e.g. through the stomach and into the small intestine), as described herein.

Abstract: The present disclosure describes a number of anti-TNFR2 (tumor necrosis factor receptor 2) antibodies. These antibodies are TNFR2 agonists. In certain cases, these antibodies agonize TNFR2 in an Fc independent manner. These antibodies can modulate the proliferation and/or functions of regulatory T cells and myeloid-derived suppressor cells. In certain instances, these antibodies can be used to treat diseases such as GvHD or autoimmune diseases.

Abstract: A method and system are directed to designing a low-dropout regulator (LDO) circuit and using the LDO circuit to detect recycled counterfeit integrated circuits. The LDO circuit includes, in part, a reference path circuit and a stressed path circuit. Each of the reference path circuit and the stressed path circuit is coupled to a control signal that can enable the corresponding path circuit for the LDO. LDO parameters can then be measured while the reference path circuit and the stressed path circuit is enabled respectively. The difference between the LDO parameters measured while the reference path circuit is enabled and while the stressed path circuit is enabled is used to determine if an integrated circuit comprising the LDO circuit is a recycled counterfeit.

Abstract: Provided herein are methods for promoting biostasis or preservation of a cell, tissue or organ during cancer treatment or for transplantation comprising contacting the cell, tissue or organ with an agonist of the ?-opioid receptor, SNC-80, an or Donepezil. Further provided herein is a method of treating a hematological neoplastic disease.

Abstract: Methods and systems are provided for regulating the temperature of rear axle lubrication oil. In one example, a rear axle coolant system may include a coolant loop with a plurality of valves and sensors, regulating the coolant flow in heat exchange relationship with an exhaust gas heat recovery and storage system to deliver warm coolant to a rear axle heat exchanger to warm the rear axle lubrication oil. The method may regulate the components of the rear axle coolant system through a controller, receiving sensor input from the components of the coolant system.

Abstract: An auto-injector is provided which includes a housing with a syringe slidably received therein. The syringe has a barrel with a piston movable therein and a needle extending therefrom. The piston is releasably secured to one end of a plunger which is slidably secured within a body in the housing and is operable through a bias provided by a motive source. In use, the plunger moves under the bias from a loaded condition to a discharged condition to move the syringe so that the needle extends from a tip at an injection end of the housing and to slide the piston within the barrel to expel the contents of the syringe. The plunger is held in the loaded condition against the bias by a detent extending from the body and which can be selectively released by operation of an actuator when pressure is applied to the tip.

Abstract: Disclosed are apparatus, compositions, and methods for promoting regeneration of tissue on a subject such as a wounded, damaged, or injured appendage, or within a subject such as a wounded, damaged, or injured organ. The disclosed apparatus, composition, and methods include or utilize wearable sleeves and regenerative compositions.

Abstract: A system includes a signal generator, configured to pass a generated signal, which has two different generated frequencies, through a circuit including an intrabody electrode. The system further includes a processor, configured to identify, while the generated signal is passed through the circuit, a derived frequency, which is derived from the generated frequencies, on the circuit, and to generate, in response to identifying the derived frequency, an output indicating a flaw in the electrode. Other embodiments are also described.

Abstract: A data resolution system provides users with the ability to access and create associations between data items tagged in documents as part of an initial process of identifying data items to be tagged in the documents. Thus, the user that is adding tags to the documents is able to identify related data items from other data sources and create links with those data sources. This ability to identify links at the time of tagging reduces the need for later searching of data sources for related data items. Additionally, the system automatically stores information regarding each link so that information regarding the linked data items may be viewed alongside the original document and/or further information regarding the linked data item is easily accessible. Data items that are tagged in a document may be associated with data items representing the same object, but with different identifiers, names, etc. in external data sources.

Abstract: Methods and system for operating a thermal storage device of a vehicle system are provided. In one example, a method comprises estimating a temperature of a thermal battery after the battery and coolant included therein have reached thermal equilibrium, and determining a state of charge of the battery based on the estimated temperature and one or more chemical properties of two phase change materials included within the battery. Specifically, the thermal battery may include two phase change materials with different melting points for providing thermal energy to warm coolant in a vehicle coolant system.

Abstract: A method of forming a security device includes: a holographic image layer, diffusion element, and barrier layer. A region of the barrier layer includes a heat-transformable material. The method further includes selectively applying heat at a plurality of positions within the region of the barrier layer, in accordance with a predetermined pattern, so as to modify the heat-transformable material such that the region of the barrier layer is selectively rendered passable to the diffusible substance at each of the plurality of positions, thereby permitting diffusion of the diffusible substance between the regions of the diffusion element and the holographic image layer such that, at a plurality of positions within the region of the holographic image layer and corresponding to the predetermined pattern, the volume hologram is dimensionally modified so as to become viewable in a second observable colour, different from the first observable colour.

Abstract: A data resolution system provides users with the ability to access and create associations between data items tagged in documents as part of an initial process of identifying data items to be tagged in the documents. Thus, the user that is adding tags to the documents is able to identify related data items from other data sources and create links with those data sources. This ability to identify links at the time of tagging reduces the need for later searching of data sources for related data items. Additionally, the system automatically stores information regarding each link so that information regarding the linked data items may be viewed alongside the original document and/or further information regarding the linked data item is easily accessible. Data items that are tagged in a document may be associated with data items representing the same object, but with different identifiers, names, etc. in external data sources.