Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: A push gateway brokers messages between backend services and client devices connected to the gateway. The gateway includes a plurality of messaging frontend servers, a messaging database, and a plurality of topic servers. The messaging frontend servers manage the socket connections connecting the client devices to the push gateway. The messaging frontend servers may further monitor the socket connections, collecting analytical data on the client devices and the connections. The messaging database is a key-value database that subscribes messaging frontend servers to topics. The topic servers receive publish requests from the backend servers to identify subscribed messaging frontend servers in the messaging database to push messages out to. The frontend messaging servers subsequently push out the message to the client devices subscribed to the topic.

Abstract: A door handle assembly includes a chassis, first and second trim plates, and a latch assembly. The chassis includes an interior chassis portion and an exterior chassis portion. The interior chassis portion is configured to extend from a first side of a door and includes at least one trim engagement mechanism. The exterior chassis portion is configured to extend from a second side of a door and includes at least one trim engagement mechanism. The first trim plate is configured to removably engage the first trim engagement mechanism, optionally via a trim plate adapter. The second trim plate is configured to removably engage the second trim engagement mechanism, also optionally via a trim plate adapter. The latch assembly extends between the exterior chassis portion and the interior chassis portion. The first trim engagement mechanism and the second trim engagement mechanism are capable of removably engaging with interchangeable trim plates.

Abstract: In particular embodiments, a computing system may capture a first image of a scene using a first camera of an artificial reality device. The system may capture a second image of the scene using a second camera and one or more optical elements of the artificial reality device. The second image may include an overlapping portion of multiple shifted copies of the scene. The system may generate an upsampled first image by applying a particular sampling technique to the first image. The system may generate a tiled image comprising a plurality of repeated second images by applying a tiling process to the second image. The system may generate an initial output image by processing the upsampled first image and the tiled image using a machine learning model. The system may generate a final output image by normalizing the initial output image using the upsampled first image.

Abstract: Susceptor assemblies having a susceptor base with a plurality of pockets formed in a surface thereof are described. Each of the pockets has a pocket edge angle in the range of 30 to 75° and a pocket edge radius in the range of 0.40±0.05 mm to 1.20 mm±0.05 mm. The pockets have a raised central region and an outer region that is deeper than the raised central region, relative to the surface of the surface of the susceptor base.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A Service Capability Exposure Function for a UE (U-SCEF) may be part of the UE's operating system (OS) and expose API's to applications that allow these applications to schedule data plane communications such as periodic sensor measurements or a firmware download. The U-SCEF communicates with an EPC Interworking Service that resides in the mobile network operator's (S)Gi-LAN. The EPC Interworking Service serves as an interface between the U-SCEF and the service capabilities that are exposed by the MNO via the SCEF. The U-SCEF may provide the EPC Interworking Service with information about the UE's anticipated communication schedule and mobility status. The EPC Interworking Service uses the services that are exposed by the SCEF to determine the optimal times for the UE to communicate, an optimal mobility management configuration, etc. The EPC Interworking Service negotiates a communication schedule with the EPC (SCEF) and policies on behalf of the U-SCEF.

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

Abstract: Alloyed metals, and techniques for creating parts from alloyed metals, are disclosed. An apparatus in accordance with an aspect of the present disclosure comprises an alloy. An additive manufacturing alloy in accordance with the present disclosure may comprise magnesium (Mg) that is between 2.0 and 5.3% by weight, manganese (Mn) that is between 0.01 and 4.0% by weight, silicon (Si) that is between 0.1 and 1.5% by weight, zirconium (Zr) that is between 0.01 and 2.0% by weight, and aluminum (Al). In some cases, the alloy such as described in the previous sentence might not include Mg.

Abstract: Methods, apparatus, and systems are described for improved edge network access for a UE. According to some aspects, a UE may receive a first Data Network Name (DNN) from an application and determine, based on a Data Network Name (DNN) Replacement Rule, the first DNN is associated with a second Data Network Name (DNN), where the first DNN and the second DNN are different. The UE may determine, based on the DNN Replacement Rule, to associate traffic from the application with a Protocol Data Unit (PDU) Session, where the PDU Session may be used to send data from the application to a network and the PDU Session is associated with the second DNN.

Abstract: Embodiments of a vehicle interior system are disclosed. In one or more embodiments, the system includes a base with a curved surface, and a display or touch panel disposed on the curved surface. The display includes a cold-bent glass substrate with a thickness of 1.5 mm or less and a first radius of curvature of 20 mm or greater, and a display module and/or touch panel attached to the glass substrate having a second radius of curvature that is within 10% of the first radius of curvature. Methods for forming such systems are also disclosed.

Abstract: Video analytics are used to evaluate interactions between humans and animals and identify possible occurrences of animal abuse in an objective manner. The video analytics system processes successive video frames to identify objects of interest (e.g., humans, animals, tools/weapons, etc.), creates mathematical models of such objects (e.g., essentially stick-figure models), analyzes movements of such objects (e.g., the speed and/or directional motion of an object or portion of an object such as an arm or leg), determines mathematically and objectively whether or not the analyzed movements meet predetermined criteria for possible abuse (e.g., wherein the predetermined criteria can be mathematical models defining ethical and unethical movements), and outputs relevant information via a user interface (e.g., a list of possible abuse instances identifying the time and probability of possible abuse, from which the user can select an instance in order to view the corresponding video for human analysis).

Abstract: A refrigeration system and a lubricating method thereof. The refrigeration system (100) includes: a compressor (110), a condenser (120), an evaporator (130), and a lubrication circuit (200), the lubrication circuit including a post-lubrication flow path (230,240,260) connected from the compressor into the condenser and the evaporator respectively; and a pre-lubrication flow path (210,220,250) connected from the condenser and the evaporator into the compressor respectively; wherein after flowing from the condenser via the pre-lubrication flow path to the compressor for lubrication, a part of refrigerant for lubrication can flow back to the evaporator via the post-lubrication flow path; or after flowing from the evaporator via the pre-lubrication flow path to the compressor for lubrication, the part of refrigerant for lubrication can flow back to the condenser via the post-lubrication flow path.

Abstract: Techniques are described for preserving the inflight sessions failing over from a primary database to the replicated logical database of the primary database. In an implementation, prior to failover, when the primary database server receives a commit for a transaction, the process stores a commit indication that the transaction has been committed by performing a corresponding SQL command. The commit indication is replicated to the logical replica database by virtue of the replication of the SQL command and its execution on the logical replica database. Accordingly, the standby database server in the failover session may successfully request for the outcome of the transaction. Techniques are also described for the client-side LOB references to be preserved when failing over to the logical replica database, for AS OF queries preserved, and for versioning of checksums, signatures and structures across logical replicas.

Abstract: Systems and methods for generating a shared collaborative channel for collaboration are provided. In particular, a computing device may receive a request, from an originating member of an organization, to create the shared collaborative channel, the request including an invitee to be added to the shared collaborative channel. In response to receipt of the request, the computing device may provision a substrate group by creating a container associate with the shared collaborative channel including a substrate database associated with the shared collaborative channel, generate an invitation including a custom link to the shared collaborative channel for the invitee, and determine whether the invitee belongs to an originating collaboration team associated with the originating member based on the substrate database. If the invitee belongs to the originating collaboration team, the computing device may further update the substrate group to add the invitee as a new member of the shared collaborative channel.

Abstract: Spectral data associated with one or more regions of a surface of a substrate is identified. The substrate has been processed according to one or more first operations of a process recipe that is unknown to a system controller for the manufacturing system. The spectral data is provided as input to a machine learning model that is trained to predict, based on given spectral data, a respective process recipe associated with the substrate and one or more operations of the respective process recipe that have already been performed. A determination is made, based on one or more outputs of the machine learning model, that the substrate is associated with the process recipe and that one or more second operations are yet to be performed. The substrate is caused to be processed according to the one or more second operations of the process recipe.

Abstract: N-Acylated histidine dipeptides of formula are disclosed. The compounds are useful for treating breast cancer.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: Systems and methods for training models to improve fairness.