Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention relates to compounds of formula (I): wherein A, RA1, RA2, RB, RC and RD are as defined herein, and associated aspects.

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein R, R1, R2 and RB are as defined herein.

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention relates to compounds of formula (IW-1) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA, RB, RC and RD are as defined herein.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A technique that unfolds the nMOS-tree multiplexer to improve the propagation delay and/or active power consumption is provided. The main idea is to replicate the nMOS element of the downstream buffer, where each replica is driven by a signal that originates from earlier stages of the nMOS-tree multiplexer. This way, when passing high logic values, signals from earlier stages directly drive the downstream buffer improving the delay or the slope of the transition edge (with beneficial effects for power consumption). The passing of low logic values is still performed in the original way by the nMOS tree and the pMOS element of the downstream buffer.

Abstract: A coarse-grain reconfigurable array that implements shift operations within its interconnection network is disclosed. The interconnection network of such a coarse-grain reconfigurable array contains partially or fully populated matrices of switches, where each such matrix of switches is obtained by merging a standard diagonal switch matrix with an array shift unit. The disclosed device provides better performance when the standard routing and shift functions are both required.

Abstract: A tread belt is molded and cured in a mold having a base plate and an inverted cup-shaped top plate. A plurality of inner segments are disposed in the mold. When the mold is closed outer surfaces of the inner segments form a cylindrical surface which is in contact with an inner surface of the tread belt. A first portion of the inner segments are follower segments, a second portion of the inner segments are leader segments, and means are provided for controlling radial movement of the inner segments. A plurality of outer segments are disposed in the mold. When the mold is closed the inner surfaces of the outer segments form a cylindrical surface which is in contact with an outer surface of the tread belt, and means are provided for controlling movement of the outer segments.

Abstract: A technique that unfolds the nMOS-tree multiplexer to improve the propagation delay and/or active power consumption is provided. The main idea is to replicate the nMOS element of the downstream buffer, where each replica is driven by a signal that originates from earlier stages of the nMOS-tree multiplexer. This way, when passing high logic values, signals from earlier stages directly drive the downstream buffer improving the delay or the slope of the transition edge (with beneficial effects for power consumption). The passing of low logic values is still performed in the original way by the nMOS tree and the pMOS element of the downstream buffer.

Abstract: The invention provides a tire mold having a first mold half, a second mold half, and a center ring portion formed of a plurality of tread segments. Each mold half has an inner surface machined with a sidewall molding portion and each of said tread segments having an inner surface having a tread molding portion, each tread molding portion terminating at a first split plane and a second split plane. Each of the center ring segments further comprise a first segment register surface for engagement with a first mold register surface of the first mold half; said center ring segments further comprising a second segment register surface for engagement with a second mold reverse register surface of the second mold half; and wherein each of said tread segments has a radially outward flange forming a hinge for rotatably mounting each tread segments to the second mold half.

Abstract: A tamper proof transdermal alcohol content monitoring device is made up of analog and digital sides which are securely attached to the human subject to be monitored. The analog side has a sampling circuit which draws a measured insensible skin perspiration sample from the skin of the subject and measured with an electrochemical fuel cell. A distance measurement of the device from the skin of the subject and temperature of the sample are monitored along with the transdermal alcohol content, and converted to digital signals which are transmitted to a modem when the monitor is in proximity to the modem. The signals are stored in the modem and uploaded to a central monitoring station. Automatic alerts may be sent from the central monitoring station to a supervising agency. The supervising agency may also access the information through secured dedicated websites via the Internet.

Abstract: An annular mold for curing an annular ring tread is disclosed. The annular mold has a plurality of radially movable and outwardly expandable inner segments for forming the inner surface of the tread and a plurality of radially movable and inwardly contracting outer segments for forming the tread outer surface. The radially outer segments are parallelograms. Each outer segment when in a closed molding position spans across one full radially inner segment and portions of two adjacent inner segments. The radially outer segments have inclined laterally extending edges relative to the axial direction of the mold while the circumferentially extending axially outer edges are perpendicular to the axial direction of the mold. The inclined laterally extending edges are inclined at least 5°, preferably about 10° relative to the axial direction. In the preferred embodiment the mold has 12 outer segments, each segment being of an arc length of about 30°.

Abstract: An annular mold for curing an annular ring tread is disclosed. The annular mold has a plurality of radially movable and outwardly expandable inner segments for forming the inner surface of the tread and a plurality of radially movable and inwardly contracting outer segments for forming the tread outer surface. The radially outer segments are parallelograms. Each outer segment when in a closed molding position spans across one full radially inner segment and portions of two adjacent inner segments. The radially outer segments have inclined laterally extending edges relative to the axial direction of the mold while the circumferentially extending axially outer edges are perpendicular to the axial direction of the mold. The inclined laterally extending edges are inclined at least 5°, preferably about 10° relative to the axial direction. In the preferred embodiment the mold has 12 outer segments, each segment being of an arc length of about 30°.