Abstract: A bone replacement material and methods for making and using the same are disclosed. In one embodiment, the bone replacement material comprises a viscous component. The bone replacement material also comprises a plurality of biodegradable inclusions, wherein the inclusions comprise polymers. The inclusions can comprise polymers with therapeutic agents. In other embodiments, the inclusions have a high surface to volume ratio.

Abstract: Methods and apparatus for non-invasively assessing physiological hard of soft tissue of human and other species are described. In a preferred embodiment, tissue is vibrationally stimulated in vivo through a frequency spectrum. The tissue reacts against the stimulus and the reaction is preferably measured and recorded. Based on analytical algorithms or comparisons with previously taken measurements, changes within the tissue can be detected and used for diagnostic purposes. Further embodiments describe the usage of the device and methods for in vivo intra-operative and post-operative implant evaluations and as a therapeutic tool.