Patents by Inventor Michael Limbert

Michael Limbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
    Patent number: 5958413
    Abstract: A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1(5-oxo-hexyl)xanthine (known as Pentoxifylline or TRENTAL) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanized recombinant antibody or fragment.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: September 28, 1999
    Assignees: Celltech Limited, Hoechst Aktiengesellschaft
    Inventors: Hiristo Anagnostopulos, Ulrich Gebert, Heinz Hanel, Michael Limbert, Mark William Bodmer, Gerald Anthony Higgs
  • Glycopeptides, a process for their preparation and their use
    Patent number: 5763397
    Abstract: Desmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: June 9, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Michael Limbert
  • Glycopeptides a process for their preparation and their use
    Patent number: 5721208
    Abstract: Novel glycopeptides, a process for their preparation and their useDesmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Michael Limbert
  • Compounds 31668P and 31668U, a process for their production and their use
    Patent number: 5459141
    Abstract: Compounds 31668P and 31668U, a process for their production and their use.Compound 31668P and compound 31668U with the formulae ##STR1## have an antibiotic and an antitumor action.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: October 17, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laslo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Matthias Helsberg, Herbert Kogler, Michael Limbert, Dieter-Andreas Sukatsch, Ramaiyer R. Chandran, Bimal N. Ganguli
  • Tetracyclic antibiotics and processes for their preparation
    Patent number: 5405844
    Abstract: Tetracyclic antibiotics and processes for their preparation .beta.-Lactam antibiotics of the formula I, and their pharmaceutically tolerable salts ##STR1## where X is (CH.sub.2).sub.0-2, CR(a)R(b), O, SO.sub.0-2 or NR(c),R1, R2 and R3 are a multiplicity of substituents, are outstanding antibiotics with remarkably good antibacterial activity both against gram-positive and against gram-negative microorganisms. They have a high stability to renal dehydropeptidase.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: April 11, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Theo Wollmann, Michael Limbert, Astrid Markus
  • Pharmaceutical combination preparations containing cephalosporin and xanthine derivatives and their use
    Patent number: 5350753
    Abstract: Pharmaceutical combination preparations containing cefotaxime and at least one xanthine derivative are suitable for the treatment of bacterial infectious diseases and for the treatment of septic shock.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: September 27, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Klesel, Michael Limbert, Elmar Schrinner
  • Pharmaceutical formulation for the treatment of bacterial infections
    Patent number: 4919932
    Abstract: A pharmaceutical formulation having a synergistic anti-bacterial activity and comprising(a) a cephalosporin derivative or a physiologically acceptable salt or ester thereof and(b) a penem antibiotic of the basic structure (B) ##STR1## or a physiologically acceptable salt or ester thereof, a process for preparing such a formulation and its use for the treatment of bacterial infections.
    Type: Grant
    Filed: June 2, 1987
    Date of Patent: April 24, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Limbert, Elmar Schrinner, Gerhard Seibert
  • 1,3-thiazoles and their use as immunomodulators
    Patent number: 4762848
    Abstract: Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and pharmaceutical agents, which contain a sulfide of this type, for these indications.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: August 9, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Scheunemann, Walter Durckheimer, Jurgen Blumbach, Michael Limbert, Hans-Ulrich Schorlemmer, Gerhard Dickneite, Hans-Harald Sedlacek
  • Use of cephem compounds as immunomodulators
    Patent number: 4701452
    Abstract: The use of cephem compounds of the general formula I ##STR1## to increase the immunological responsiveness of mammals and formulations which contain an effective content of cephem compounds of the general formula I.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: October 20, 1987
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Limbert, Walter Durckheimer, Hans-Ulrich Schorlemmer, Gerhard Dickneite