Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: The present disclosure relates to viral particles for use in treating tauopathies, particularly Alzheimer's disease, by gene therapy. More specifically, the present invention relates to a viral particle for use in treating tauopathies by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebro sidase.

Abstract: The present disclosure relates to viral particles for use in treating synucleinopathies, particularly sporadic Parkinson Diseases by gene therapy. More specifically, the present invention relates to a viral particle for use in treating synucleinopathy by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebrosidase.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: A motor vehicle device includes a movable windowpane, which can be moved into a first end position, and an actuation mechanism having a touch-sensitive surface and by which a sliding movement of an operating element on the surface can be detected. The actuation mechanism cooperates with a drive of the windowpane in such a way that the windowpane is moved into the first end position when a sliding movement occurring at least in part in a predetermined first movement direction is detected.

Abstract: A piece of furniture, in particular in the form of a piece of display furniture and preferably in the form of a piece of display furniture for displaying goods, further preferably a piece of modular-construction furniture in the form of a rack or cabinet, comprising a plurality of furniture elements, designed preferably as display-furniture elements, in the form of surface-area elements (1, 2) and connecting elements (4), it being possible for the latter to be fitted on narrow sides of the surface-area elements (1, 2), wherein the connection on the narrow sides, it being possible for said connection to be released without the use of tools, takes place via a tongue structure which can be introduced into a groove structure, preferably via a tongue which can be introduced into a groove or via a multiple tongue, designed at least in the form of a double tongue, which can be introduced into a multiple groove, designed at least in the form of a double groove, and wherein the furniture elements (1, 2, 4) are secured

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: A motor vehicle device includes a movable windowpane, which can be moved into a first end position, and an actuation mechanism having a touch-sensitive surface and by which a sliding movement of an operating element on the surface can be detected. The actuation mechanism cooperates with a drive of the windowpane in such a way that the windowpane is moved into the first end position when a sliding movement occurring at least in part in a predetermined first movement direction is detected.

Abstract: A piece of furniture, in particular in the form of a piece of display furniture and preferably in the form of a piece of display furniture for displaying goods, further preferably a piece of modular-construction furniture in the form of a rack or cabinet, comprising a plurality of furniture elements, designed preferably as display-furniture elements, in the form of surface-area elements (1, 2) and connecting elements (4), it being possible for the latter to be fitted on narrow sides of the surface-area elements (1, 2), wherein the connection on the narrow sides, it being possible for said connection to be released without the use of tools, takes place via a tongue structure which can be introduced into a groove structure, preferably via a tongue which can be introduced into a groove or via a multiple tongue, designed at least in the form of a double tongue, which can be introduced into a multiple groove, designed at least in the form of a double groove, and wherein the furniture elements (1, 2, 4) are secured

Abstract: The present disclosure described a vehicle seat that includes a seat part with an elastic seat padding, a backrest part with an elastic backrest padding, and a seat cover for the seat part and a seat cover for the backrest part. The elastic seat padding has a primary seat padding part and at least one secondary seat padding part. The elastic backrest padding has a primary backrest padding part and at least one secondary backrest padding part. The secondary seat padding and the secondary backrest padding part are softer than the primary seat padding and the primary backrest padding part, respectively.

Abstract: The present disclosure described a vehicle seat that includes a seat part with an elastic seat padding, a backrest part with an elastic backrest padding, and a seat cover for the seat part and a seat cover for the backrest part. The elastic seat padding has a primary seat padding part and at least one secondary seat padding part. The elastic backrest padding has a primary backrest padding part and at least one secondary backrest padding part. The secondary seat padding and the secondary backrest padding part are softer than the primary seat padding and the primary backrest padding part, respectively.

Abstract: The present invention provides methods for adenoassociated virus-mediated site-specific integration of a transgene into a stem cell. Stem cells having a transgene integrated therein, and differentiated cells generated from the stem cells are also provided.

Abstract: Transgenic non-human animals with expanded mature B cell and plasma cell populations are described, as well as methods of using the transgenic non-human animals to screen for pharmaceutically active agents and to produce targeted antibodies.

Abstract: The invention relates to a rear axle arrangement for a heavy vehicle, e.g. a freight vehicle. The vehicle incorporates a number of wheels which bear the vehicle and an elongate chassis element which extends in the longitudinal direction of the vehicle. The rear axle arrangement incorporates at least one separate rear axle unit which includes a loadbearing frame structure and two of said wheels. The frame structure extends between a first end region and a second end region in the longitudinal direction of the vehicle and the first end region of the frame structure is designed to be connected to the elongate chassis element. In addition, the two wheels are suspended on the frame structure.

Abstract: Cab-over-engine freight vehicle with a driver's cab which is untiltable relative to the chassis and is situated above the vehicle's engine which is supported by the chassis. On each side of the vehicle there is a panel which is provided with steps, delineates the engine compartment laterally and is mounted pivotably on the chassis by means of a panel control arrangement which makes it possible to impart a displacement movement to the panel so that it swings outwards and rearwards in the longitudinal direction of the vehicle to an engine access position. Below the door of the driver's cab there is a cover which is hinged-mounted on the chassis and which in the closed position conceals the step panel situated inside it. The cab door and the cover below the door are detachably coupled with one another by a relative-motion absorbing control arrangement.

Abstract: A motor vehicle with a forward-mounted engine and a forward-situated air intake has a tubular chassis element running in the longitudinal direction of the vehicle. Between the air intake and the chassis element there is a guide arrangement for leading air into and through the chassis element past at least one major vehicle component, advantageously the vehicle's gearbox, situated inside the chassis element. Downstream from that major vehicle component there is an air outlet.

Abstract: The invention relates to a front axle arrangement for a heavy vehicle, e.g. a freight vehicle. The vehicle incorporates a number of wheels (42, 43) which bear the vehicle, and an engine unit (20) for the vehicle's propulsion and a longitudinal chassis element (6) which extends along the vehicle's longitudinal axis in the normal direction of forward movement of the vehicle. The front axle arrangement forms a separate front axle unit (11) incorporating a frame structure (12-15) which is intended to be connected to the longitudinal chassis element, and two of said wheels which are suspended in the frame structure. The front axle unit (11) is intended to bear the engine unit (20) in such a way that the latter extends in through a central aperture of the frame structure (12-15) and can at least partially be extracted from the front axle unit.

Abstract: A loadbearing structure for heavy vehicles, e.g. a freight vehicle, incorporates a box-shaped hollow unit (10) extending in the longitudinal direction of the vehicle. Wall elements (12, 14, 16, 18) of thin wall thickness are connected to one another to form the box-shaped unit (10). The invention provides a loadbearing structure (2) for heavy vehicles which is many times more rigid than conventional structures but is nevertheless of relatively low weight and is relatively easy and inexpensive to manufacture. The present invention also relates to a process for manufacturing a loadbearing structure for heavy vehicles.