Abstract: Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Abstract: Progressive ammunition press system, components thereof, and associated methods. The press system may include a press control system integrated with the press. The press may include a case carriage including a case carrier supported by a bearing. Case retainer gates may be provided for retaining cases in the case carrier. A bullet feeding system can be arranged to permit bullet feeding and seating in a single station of the press. A primer feeder can be self-contained, gear-driven, and/or recirculating.

Abstract: A knife comprising a handle and a blade assembly. The blade assembly includes a blade, a tang, and blade assembly connection structure. The handle includes a receiver configured to receive the tang, and includes handle connection structure. The blade assembly connection structure and handle connection structure are arranged to releasably lock the blade assembly in an installed position on the handle with the tang in the tang receiver.

Abstract: Target hit indicator and associated components and methods. The target hit indicator includes a housing that houses various electronic components and supports at least one light source. The target hit indicator is mountable on a target and configured to detect hits on the target and to activate the at least one light source to indicate such hits.

Abstract: A knife comprising a handle and a blade assembly. The blade assembly includes a blade, a tang, and blade assembly connection structure. The handle includes a receiver configured to receive the tang, and includes handle connection structure. The blade assembly connection structure and handle connection structure are arranged to releasably lock the blade assembly in an installed position on the handle with the tang in the tang receiver.

Abstract: An inertia bullet remover and associated methods for removing a bullet from an ammunition casing. The inertia bullet remover includes a carriage for carrying the ammunition casing. The carriage is movable with respect to a base between a first position and a second position. Movement of the carriage is guided by a guide. Movement of the carriage is stopped by a stop, which causes the bullet to exit the ammunition casing via inertia.

Abstract: Disclosed are processes for manufacturing cross-linked cellulosic fibers and tissue products comprising cross-linked cellulosic fibers, manufactured by reacting an oxidized polyol, in particular, an oxidized sugar having at least two aldehyde groups with a plurality of cellulosic fibers to yield treated fibers and heating the treated fibers at a temperature greater than about 140° C. to cure the treated fibers. In particular, said sugar is sucrose and the oxidising agent comprises hydrogen peroxide. The instant cross-linked fibers are manufactured without well-known cross-linking agents such as formaldehyde or polycarboxylic acids, and have good brightness and color and resist yellowing. Furthermore, the cross-linked cellulosic fibers are generally free from off odors and the instant cross-linked cellulosic fibers have enhanced properties, such as improved wet bulk, compared to uncross-linked fibers.

Abstract: This invention relates to an RNA trans-splicing molecule (RTM) that targets human endogenous retrovirus (HERV) pre-mRNA. The RTM comprises (i) a binding region specific for a HERV pre-mRNA, (ii) a trans-splicing splice domain and (ill) a coding sequence for a suicide protein. The binding region of the RTM binds to HERV pre-mRNA in a cell, such that the coding sequence is trans-spliced through the trans- splicing domain with the HERV pre-mRNA, resulting in a chimeric mRNA causing the suicide protein to be expressed in the cell. RTMs of the invention may be useful in selectively killing cells that express HERV genes, for example cancer cells. RTMs, encoding nucleic acids, methods of treatment and associated methods and uses are provided.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes a slide bearing about which the ram of the ammunition press moves to provide smooth operation of the ammunition press. A configurable spent primer system is provided to enable a user to select how they want to collect spent primers or other debris from the ammunition press. According to a user's preference, the ammunition press can also be customized to provide a cam-over or non-cam-over sensation as the user operates the ammunition press. A light is integrated with the ammunition press for illuminating a shell holder that holds the ammunition shells (sometimes called cases). Components of the ammunition press and associated methods are also disclosed.

Abstract: According to an aspect of the present invention, there is provided a method for rendezvous with an orbiting object comprising: launching a tug and a servicer into a client orbit; separating the servicer from the tug; and docking the servicer with a client. According to another aspect of the present invention, there is provided system for rendezvous with an orbiting object comprising: a first spacecraft raft comprising a tug capable of towing a second spacecraft, wherein the second spacecraft is a servicer configured to dock with a tumbling client orbiting object.

Abstract: According to an aspect of the present invention, there is provided a method comprising: propelling a servicing spacecraft to an object; deploying one or more counter mass(es) away from a servicing spacecraft bus to offset the center of mass of the servicing spacecraft into an empty volume; approaching the object, by the servicing spacecraft; positioning the center of mass of the servicing spacecraft in approximately the same location as the center of mass of the object; imparting angular momentum to the servicing spacecraft to match the tumble rate of the object; and contacting the object with one or more mechanical attachments to the servicing spacecraft.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes a slide bearing about which the ram of the ammunition press moves to provide smooth operation of the ammunition press. A configurable spent primer system is provided to enable a user to select how they want to collect spent primers or other debris from the ammunition press. According to a user's preference, the ammunition press can also be customized to provide a cam-over or non-cam-over sensation as the user operates the ammunition press. A light is integrated with the ammunition press for illuminating a shell holder that holds the ammunition shells (sometimes called cases). Components of the ammunition press and associated methods are also disclosed.

Abstract: A shooting target thrower for throwing a shooting target includes a throwing arm rotatable about a throwing axis to throw the shooting target. A throwing spring is operatively coupled to the throwing arm and rotates the throwing arm to throw the shooting target. A drive train is operatively coupled to the throwing arm and includes a charge pedal and a fire pedal. The charge pedal rotates the throwing arm toward a cocked position. The fire pedal releases the throwing arm to rotate, under a force of the throwing spring, from the cocked position to throw the shooting target.

Abstract: A shooting target thrower for throwing a shooting target includes a throwing arm rotatable about a throwing axis to throw the shooting target. A throwing spring is operatively coupled to the throwing arm and rotates the throwing arm to throw the shooting target. A drive train is operatively coupled to the throwing arm and includes a charge pedal and a fire pedal. The charge pedal rotates the throwing arm toward a cocked position. The fire pedal releases the throwing arm to rotate, under a force of the throwing spring, from the cocked position to throw the shooting target.