Abstract: The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Abstract: An electrode device for recording electrophysiological neurosignals in nervous tissue of a living being includes a bundle of insulated electrical cables, where each cable has an electrical wire made of electrically conductive material and an insulation layer which covers and insulates the electrical wire. An electrical connector connects the electrical wires to a recording device. A free end of the bundle of insulated electrical cables distant from the electrical connector includes an implantation section for implantation in the nervous tissue of the living being. An electrophysiological recording system will have at least one such electrode device and a computer program arranged for execution on a computer.

Abstract: A micro-electrode array (1) comprising a flexible substrate (2) and a multiplicity of electrodes (3) for electrically measuring neural activity is described. The electrodes (3) are arranged on the substrate (2), project from the plane of the substrate (2) and have a core (4). A plurality of measurement lines (9) that are electrically insulated from one another are arranged around the core (4). Adjacent to the end surface (7) of the core (4), at the end of the electrodes (3) there are a plurality of electrode surfaces (8) arranged in a manner distributed spatially around the end surface (7), said electrode surfaces in each case being electrically conductively connected to an associated measurement line (9). The micro-electrode array (1) is passivated with a polymer-containing material, such as e.g. polyimide, such that only the electrodes (3) electrically contact neural tissue with their electrode surfaces (8, E1, E2).

Abstract: The invention relates to a method for obtaining brain wave data using a microelectrode array, comprising a plurality of electrodes for electrically measuring brain waves and an integrated optical stimulation unit for stimulating brain regions by means of optical signals, wherein the stimulation unit has one or more electrical light sources, and wherein the method includes stimulating neurons of the brain via optical signals produced by the light sources, recording a response of the neurons to the stimulation via the electrodes, unambiguously assigning the recorded response to individual optical stimulation signals provided by the light source, and determining an unambiguous correlation between the optical stimulation signals and resulting brain waves measured by the electrodes.

Abstract: The invention relates to an optical stimulation device for stimulating nerve cells, wherein the stimulation device has at least one implant component, which is designed for implanting in a natural inner cavity of the body of a living being, through which cavity a bodily fluid flows, having the following features: a) the implant component has at least one supporting structure, which can be expanded in a radial direction for fastening in the natural inner cavity, b) a plurality of light sources is fastened to the supporting structure, which light sources are designed to emit light in the radial direction with respect to the supporting structure, c) a plurality or electrodes is fastened to the supporting structure, which electrodes are designed to capture electrical body signals, d) the supporting structure has a plurality of openings and/or channels, through which the bodily fluid can flow after implantation in the body.

Abstract: The invention relates to a microelectrode array, comprising a plurality of electrodes for electrically measuring brain waves and an integrated optical stimulation unit for stimulating brain regions by means of optical signals, wherein the stimulation unit has one or more electrical light sources.

Abstract: A micro-electrode array (1) comprising a flexible substrate (2) and a multiplicity of electrodes (3) for electrically measuring neural activity is described. The electrodes (3) are arranged on the substrate (2), project from the plane of the substrate (2) and have a core (4). A plurality of measurement lines (9) that are electrically insulated from one another are arranged around the core (4). Adjacent to the end surface (7) of the core (4), at the end of the electrodes (3) there are a plurality of electrode surfaces (8) arranged in a manner distributed spatially around the end surface (7), said electrode surfaces in each case being electrically conductively connected to an associated measurement line (9). The micro-electrode array (1) is passivated with a polymer-containing material, such as e.g. polyimide, such that only the electrodes (3) electrically contact neural tissue with their electrode surfaces (8, E1, E2).

Abstract: The invention relates to an optical stimulation device for stimulating nerve cells, wherein the stimulation device has at least one implant component, which is designed for implanting in a natural inner cavity of the body of a living being, through which cavity a bodily fluid flows, having the following features: a) the implant component has at least one supporting structure, which can be expanded in a radial direction for fastening in the natural inner cavity. b) a plurality of light sources is fastened to the supporting structure, which light sources are designed to emit light in the radial direction with respect to the supporting structure, c) a plurality or electrodes is fastened to the supporting structure, which electrodes are designed to capture electrical body signals, d) the supporting structure has a plurality of openings and/or channels, through which the bodily fluid can flow after implantation in the body.

Abstract: An implantable medical device includes an integrated or connectable implantable three-dimensional acceleration sensor, and a ballistocardiogram (BCG) capturing unit that is connected or connectable to the acceleration sensor. The BCG evaluation unit processes an acceleration signal provided by the acceleration sensor and derives a BCG from the 3D accelerometer output signal. A BCG evaluation unit is connected to the BCG capturing unit, and is designed to evaluate a BCG provided by the BCG capturing unit and supply an output signal representing stroke volume.

Abstract: A medical device includes a preload determination unit for determining the preload of a ventricle for a cardiac cycle and providing a preload value representing the preload; a contractility determination unit for determining the contractility of the ventricle for the cardiac cycle and providing a contractility value representing the contractility; and an evaluation unit connected to the preload determination unit and the contractility determination unit, with the evaluation unit being configured to evaluate contractility values versus associated preload values.

Abstract: A first plurality of images of a scene may be captured. Each image of the first plurality of images may be captured using a different TET. Based at least on the first plurality of images, a long TET, a short TET, and a TET sequence that includes the long TET and the short TET may be determined. A second plurality of images of the scene may be captured. The images in the second plurality of images may be captured sequentially in an image sequence using a sequence of TETs corresponding to the TET sequence. Based on one or more images in the image sequence, an output image may be constructed.

Abstract: An implantable cardiac stimulator includes at least one first sensing unit for detecting intrinsic cardiac activities of a first ventricle, at least one ventricular stimulation unit for stimulating a second ventricle, and a stimulation control unit connected to the first sensing unit. The stimulation unit processed output signals of the first sensing unit and generates control signals for the stimulation units. The stimulation control unit derives a current intrinsic RR interval from detected ventricular intrinsic cardiac activities R of the first ventricle, and to determine from the RR interval a delay interval ?, which begins with a ventricular event of the first ventricle and at the end of which the stimulation control unit triggers a stimulation of the second ventricle (unless it is suppressed).

Abstract: An electromedical implant for monitoring a thoracic property of a living being is provided that includes a detector arrangement including an impedance measuring unit and an electrode arrangement, which are equipped to capture a measurement signal associated with the thoracic property in the form of an impedance signal; a monitoring arrangement, which is connected to the detector arrangement and equipped to generate a parameter from the measurement signal that is indicative of the thoracic property, and an evaluation unit, which is connected to the monitoring arrangement and equipped to determine an evaluation result regarding the thoracic property based on the parameter. According to the invention, the electrode arrangement comprises at least a plurality of mutually isolated electrodes, which are disposed on the housing and operatively connected by way of the impedance measuring unit and which can be separately controlled, wherein an electrode body has a strip shape.

Abstract: A monitoring device for a patient for predicting a cardiovascular anomaly and a method for operating a monitoring device is provided. Furthermore, an implantable electrotherapy device, such as an implantable cardiac pacemaker, an implantable cardioverter, or an implantable defibrillator, having a monitoring device are also provided. In an embodiment, the monitoring device acquires a value change of a hemodynamic parameter, which occurs as a result of a detected value change of a state parameter, for example, as a result of an activation or deactivation of a cardiac resynchronization therapy. By suitable evaluation of the value change of the hemodynamic parameter, the monitoring device can output an evaluation result signal which is indicative of an imminence of a cardiovascular anomaly, such as a cardiac decompensation, long beforehand and with high specificity.

Abstract: A system which generates a warning signal in the event of looming pulmonary edema and/or looming decompensation. The system has an impedance detection unit for determining impedance values, which represent a transthoracic impedance course, and an impedance analysis unit (78), which is connected to the impedance detection unit. The impedance analysis unit (78) is implemented to determine the degree of modulation for a particular impedance course detected by the impedance detection unit.

Abstract: An implant predicts decompensation of a patient's heart based on an acoustic pressure measurement. The implant includes first and second acoustic transducers, which are matched to each other and which rest in/on the patient's thorax. The first acoustic transducer emits an acoustic signal which has at least one first signal portion having a first frequency. The second acoustic transducer is designed to receive and re-emit the emitted acoustic signal, or to reflect it, such that the first acoustic transducer receives the emitted acoustic signal. A signal processing unit communicates with at least one of the two acoustic transducers and determines an attenuation value as a function of the attenuation of the received acoustic signal versus the originally emitted acoustic signal, and provides a prediction signal as a function of a comparison of the attenuation value to a threshold value, wherein the prediction signal indicates the development of decompensation.

Abstract: A monitoring apparatus having a signal input for signals representing measurement values of one or more physiological parameters, and an evaluation and processing unit connected to the signal input. The evaluation and processing unit is designed to select, or differently weight, individual values from the values received for further processing based on one or more criteria such that measurement values raising doubts as to the validity thereof are not selected or given a very low weighting.

Abstract: A heart stimulation system comprises an electrode lead comprising at least one stimulation electrode a stimulation pulse generator adapted to generate electric stimulation pulses and being connected to said electrode lead for delivering electric stimulation pulses to at least one chamber of a heart via said stimulation electrode, and a control unit that is connected to said stimulation pulse generator. The electrode lead is a coronary sinus lead adapted to be placed inside the coronary sinus of a human heart and comprises an ultrasonic transducer that is adapted to measure a velocity of blood flow across a mitral valve of a human heart and that is placed on said coronary sinus lead such that the ultrasonic transducer is placed in the coronary sinus or the great cardiac vein when the coronary sinus lead is in its implanted state.

Abstract: Embodiments relate to a heart monitor, which is connected to or can be connected to at least one sensor for pressure and volume data or equivalent substitute variables and which comprises an evaluation unit for processing at least one input signal reflecting the temporal course of pressure and volume data or equivalent substitute variables of the heart. The evaluation unit is configured such that it segments the input signal in accordance with individual completed cardiac cycles and examines segments of the input signal obtained in this way as to whether a particular segment of the input signal represents a PV diagram, which corresponds to specified quality conditions regarding the direction of circulation, morphology and distance between a starting and end values.

Abstract: An electromedical implant (100, 101, 102, 103) for monitoring a cardiac blood flow (B1) of a patient includes a detector (10, 10?, 10?) which obtains a first measurement signal (S1) associated with the cardiac blood flow (B1) and a second measurement signal (S2) associated with the epithoracic, peripheral blood flow (B2). A monitoring assembly (20) then generates a first parameter (P1) from the first measurement signal (S1) which is indicative of a time (tsys) at which blood is ejected from the heart, and a second parameter (2) from the second measurement signal (S2) which is indicative of a time (tgef) of a blood pulse in the thoracic tissue which is associated with the ejection of blood. An evaluation unit (30) then generates a pulse transit time (?t=tgef?tsys) from the first parameter (P1) and the second parameter (P2).