Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: A system for failure detection tools is disclosed. The system may include at least one user device, an application server, and a failure detection system, each of which may be in communication with one or more of the others via at least one network. The failure detection system may receive first data from a data source, process the first data to generate second data, apply a statistical modeling algorithm to make a prediction relating to the first data or the second data, and communicate data relating to the prediction and/or a trend related to the first data or the second data to the user device for displaying at least a portion of the data relating to the prediction and/or the trend on a display of the user device.

Abstract: A golf putter head having adjustability in weight and center of gravity. The putter head has a ball-striking front portion with a club face defining its width and height, a heal, a toe, and top and bottom surfaces defining the length of the front portion. The putter head has a front central axis extending through the center of gravity of the front portion and parallel to the top and bottom surfaces. A weight-and-balance-adjustment rear portion is connected to the front portion, which has a plurality of lengthwise-extending housings. Each housing includes an internal cavity constructed and arranged to removably contain at least one weighted slug. The putter head has a first center of gravity when the internal cavities are empty. The first center of gravity can be moved along the length, width and height of the putter by inserting weighted slugs in one or more of the cavities.

Abstract: A system for safe interaction between a human and an industrial machine includes a cyber-mechanical system. The cyber-mechanical system includes at least one industrial machine and a cyber-mechanical control system for processing inputs and producing control outputs for the at least one industrial machine; The system further includes a task planner configured to translate high level goals into scheduled tasks of the industrial machine. The system includes an interaction reasoner that identifies at least one interaction between the industrial machine and a human working in cooperation with the industrial machine. Output of the interaction reasoner is provided to an image generator that produces an interaction image. The interaction image represents information relating to one or more of the scheduled tasks of the industrial machine. An image projector associated with the industrial machine conveys information about the scheduled tasks of the associated industrial machine to the human.

Abstract: A multi-level programmable alerting system may be used with a fishing pole and a handheld device. The system includes a sensing device associatable with the fishing pole and an application associatable with the handheld device. The system detects and alerts an angler that fish are nibbling, biting, and/or striking.

Abstract: A system and method for operating a pipe loader for various applications in the drilling industry are provided. The pipe loader operates with a programmable and self-calibrating control system that allows the pipe loader to be programmed and/or to mimic previous operator-performed routes to automatically load one or more pipes from at least a first location and unload the one or more pipes at at least a second location. The pipe loader has a robotic arm with a vacuum head for engaging one or more pipes with suction. The movement of the robotic arm, along with the vacuum head, may be selectively controlled an operator or by the control system.

Abstract: An extruded railroad tie comprising a bottom, a first side and a second side essentially opposite each other and extending from opposite ends of the bottom and a top surface shaped to receive and support the bottom of a steel tie. The extruded tie is useful for support of railways in mines, tunnels and the like. The tie is compatible with steel ties and can withstand heavy loads, impacts, standing water, insects, bacteria, molds and the like. The tie is such that the steel tie associated with it is easily replaceable.

Abstract: A data card management system that consolidates and manages use of a plurality of single-function data cards using one, portable multifunction data card. The cardholder accesses the secure, internet-based system using a computer with access to the Internet. Once accessed, the user completes: (1) account registration; (2) card data collection from the user's single-function data cards; (3) profile creation defining how collected card data will be used; and (4) multifunction card data card activation choosing personalized features, which includes profiles, to be saved on the card subsequently issued to the user. Several multifunction data cards can be issued to one user account with access to the account's card data being dependent upon profiles stored on that card. The system also has the ability to assists the user in typical personal tasks, such as budgeting using a budget profile, and generating reports tracking the use of the multifunction data card.

Abstract: An improved railway frog having opposite side flangeways, each flangeway comprising a channel with an ending width greater than a corresponding channel width of a conventional frog. The improved frog channel further comprising a first segment and a second segment. The second segment having an outside wall angled greater than a corresponding first segment outside wall in relation to an inner wall of the channel.

Abstract: Apparatus and methods consistent with the present invention provide for identifying and processing mail using an identification code on a mailpiece as a redundant source of identification information in a mail sorting system. In one embodiment, this information is stored in a temporary database and used for the identification and processing of mail in a Remote Bar Code System (RBCS). In this embodiment, the identification code enables the automation of mail sorting and other processing tasks, reducing costs and delays in mail delivery services. In another embodiment, the identification and processing of mail occurs in an Identification Code Sorting (ICS) system. In this embodiment, a long-term database allows for mail sorting and other processing tasks on a national or global level.

Abstract: A framework is used for delivering data to and from a system. The framework consists of different delivery vehicles or forms to carry different types of data to and from the system. The data contains configuration information. When storing the configuration information, the framework allows the configuration information from the system to be filled in the forms. The configuration information is converted into a Generalized Markup Language (GML) format.

Abstract: The present invention provides an electrical isolation apparatus having independently controllable contactors. The isolation apparatus includes a contactor for each phase or pole of an electrical device as well as each phase or pole of a load. Each contactor is constructed so that each includes multiple contact assemblies that may be independently controlled to open and close. Moreover, the contactors within a single contactor assembly or housing can be independently controlled so that the contacts of one contactor can be opened without opening the contacts of the other contactors in the contactor assembly. Additionally, the contactors are constructed and controlled such that a single line side contactor and a single load contactor open simultaneously when an open circuit condition is desired.

Abstract: Apparatus and methods consistent with the present invention provide for processing delivery item information in an identification code sorting system by an identification code server. In one embodiment, a primary identification code server receives an identification file containing identification information uniquely corresponding to a delivery item. In this embodiment, the primary identification code server processes the delivery item information and may send the identification file to a secondary identification code server. In another embodiment, a secondary identification code server receives an identification file from a primary identification code server and processes the delivery item information.

Abstract: Apparatus and methods consistent with the present invention provide for processing delivery item information in an identification code sorting system by an identification code server. In one embodiment, a primary identification code server receives an identification file containing identification information uniquely corresponding to a delivery item. In this embodiment, the primary identification code server processes the delivery item information and may send the identification file to a secondary identification code server. In another embodiment, a secondary identification code server receives an identification file from a primary identification code server and processes the delivery item information.

Abstract: A wire grid polarizer may be fabricated by forming plurality of substantially-straight metallic lines of predetermined periodicity ? on a thin film substrate A plurality of substantially straight nanometer-scale periodic surface relief structures is created on a surface of the substrate. The periodic surface relief structures cover a region greater than about 4 centimeters in length and greater than about 4 centimeters in width, wherein the periodicity ? is between about 10 nanometers and about 500 nanometers. One or more layers of material are formed on the periodic relief structures. The one or more layers include one or more conductor materials that form the plurality of substantially straight metallic lines over a region of the substrate greater than about 4 centimeters in length and greater than about 4 centimeters in width.

Abstract: A method for forming a plurality of parallel metal lines on a substrate of thin film elastomeric material and a wire grid polarizer formed by such method. A sacrificial layer is formed by coating the substrate with a water soluble polymer while the substrate is stretched. The existing tensile force is removed, leaving an undulating topology of buckled sacrificial layer material. A masking layer is then deposited at an oblique angle and then fractured into parallel lines of material by application of a second tensile force. Unmasked portions of the sacrificial layer are removed by dry etch. A metallic layer is then deposited and a lift off process employed to remove remaining portions of the sacrificial layer and materials deposited thereover. Upon removal of the second tensile force, the substrate returns to its unstressed length with metal lines of predetermined periodicity thereon.

Abstract: Apparatus and methods consistent with the present invention provide for processing mailpiece information in an identification code sorting system by an identification code server. In one embodiment, a primary identification code server receives an identification file containing identification information uniquely corresponding to a mailpiece. In this embodiment, the primary identification code server processes the mailpiece information and may send the identification file to a secondary identification code server. In another embodiment, a secondary identification code server receives an identification file from a primary identification code server and processes the mailpiece information.

Abstract: The present invention relates to an improved railway frog having opposite side flangeways, each flangeway comprising a channel with an ending width greater than a corresponding channel width of a conventional frog. The improved frog further comprising a segment with an outside wall angle greater than a corresponding segment wall angle of a conventional frog.

Abstract: Apparatus and methods consistent with the present invention provide for identifying and processing mail using an identification code on a mailpiece as a redundant source of identification information in a mail sorting system. In one embodiment, this information is stored in a temporary database and used for the identification and processing of mail in a Remote Bar Code System (RBCS). In this embodiment, the identification code enables the automation of mail sorting and other processing tasks, reducing costs and delays in mail delivery services. In another embodiment, the identification and processing of mail occurs in an Identification Code Sorting (ICS) system. In this embodiment, a long-term database allows for mail sorting and other processing tasks on a national or global level.