Patents by Inventor Michael Litvack

Michael Litvack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of generating hemangioblasts
    Patent number: 12312598
    Abstract: A method of differentiating pluripotent stem cells into hemangioblasts comprising incubating the pluripotent stem cells in a first serum-free differentiation medium comprising bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor (VEGF) and stem cell factor (SCF) to induce differentiation of the pluripotent stem cells into hemangioblasts or hemangioblast-containing embryoid bodies is provided. The hemangioblasts or embryoid bodies may be cultured in a second differentiation medium comprising at least granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage colony stimulating factor (M-CSF) and interleukin-3 (IL-3) for a period of time sufficient to generate alveolar-like macrophages.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: May 27, 2025
    Assignee: The Hospital for Sick Children
    Inventors: Sheena Bouch, Michael Litvack, Martin Post
  • Mammalian alveolar macrophages derived from pluripotent cells
    Patent number: 12146161
    Abstract: Alveolar-like macrophages and a method for generating alveolar-like macrophages from hemangioblasts is provided. The method comprises the steps of: i) culturing the hemangioblasts in a hematopoietic-inducing medium comprising vascular endothelial growth factor (VEGF), stem cell factor (SCF) and interleukin-3 (IL-3) for a sufficient period of time to generate macrophages, and ii) culturing the macrophages in an alveolar macrophage-inducing medium comprising granulocyte macrophage colony stimulating factor (GM-CSF), and optionally macrophage colony stimulating factor (M-CSF), under suitable conditions and for a sufficient period of time to yield alveolar-like macrophages.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: November 19, 2024
    Assignee: The Hosptial for Sick Children
    Inventors: Martin Post, Michael Litvack
  • Method of Generating Hemangioblasts
    Publication number: 20220162556
    Abstract: A method of differentiating pluripotent stem cells into hemangioblasts comprising incubating the pluripotent stem cells in a first serum-free differentiation medium comprising bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor (VEGF) and stem cell factor (SCF) to induce differentiation of the pluripotent stem cells into hemangioblasts or hemangioblast-containing embryoid bodies is provided. The hemangioblasts or embryoid bodies may be cultured in a second differentiation medium comprising at el least granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage colony stimulating factor (M-CSF) and interleukin-3 (IL-3) for a period of time sufficient to generate alveolar-like macrophages.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 26, 2022
    Inventors: Sheena Bouch, Michael Litvack, Martin Post
  • MAMMALIAN ALVEOLAR MACROPHAGES DERIVED FROM PLURIPOTENT CELLS
    Publication number: 20210301256
    Abstract: Alveolar-like macrophages and a method for generating alveolar-like macrophages from hemangioblasts is provided. The method comprises the steps of: i) culturing the hemangioblasts in a hematopoietic-inducing medium comprising vascular endothelial growth factor (VEGF), stem cell factor (SCF) and interleukin-3 (IL-3) for a sufficient period of time to generate macrophages, and ii) culturing the macrophages in an alveolar macrophage-inducing medium comprising granulocyte macrophage colony stimulating factor (GM-CSF), and optionally macrophage colony stimulating factor (M-CSF), under suitable conditions and for a sufficient period of time to yield alveolar-like macrophages.
    Type: Application
    Filed: May 10, 2021
    Publication date: September 30, 2021
    Inventors: Martin Post, Michael Litvack
  • Mammalian alveolar macrophages derived from pluripotent cells
    Patent number: 11001806
    Abstract: Alveolar-like macrophages and a method for generating alveolar-like macrophages from hemangioblasts is provided. The method comprises the steps of: i) culturing the hemangioblasts in a hematopoietic-inducing medium comprising vascular endothelial growth factor (VEGF), stem cell factor (SCF) and interleukin-3 (IL-3) for a sufficient period of time to generate macrophages, and ii) culturing the macrophages in an alveolar macrophage-inducing medium comprising granulocyte macrophage colony stimulating factor (GM-CSF), and optionally macrophage colony stimulating factor (M-CSF), under suitable conditions and for a sufficient period of time to yield alveolar-like macrophages.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: May 11, 2021
    Assignee: The Hospital for Sick Children
    Inventors: Martin Post, Michael Litvack
  • Method of Treating Respiratory Tract Infection
    Publication number: 20200171085
    Abstract: A method of treating a respiratory viral infection in a mammal is provided. The method comprises administering to the mammal a therapeutically effective amount of alveolar-like macrophages, or an anti-viral factor produced by alveolar-like macrophages.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 4, 2020
    Inventors: Theo Moraes, Martin Post, Yuchen Cen, Michael Litvack
  • ALVEOLAR-LIKE MACROPHAGES AND METHOD OF GENERATING SAME
    Publication number: 20170335282
    Abstract: Alveolar-like macrophages and a method for generating alveolar-like macrophages from hemangioblasts is provided. The method comprises the steps of: i) culturing the hemangioblasts in a hematopoietic-inducing medium comprising vascular endothelial growth factor (VEGF), stem cell factor (SCF) and interleukin-3 (IL-3) for a sufficient period of time to generate macrophages, and ii) culturing the macrophages in an alveolar macrophage-inducing medium comprising granulocyte macrophage colony stimulating factor (GM-CSF), and optionally macrophage colony stimulating factor (M-CSF), under suitable conditions and for a sufficient period of time to yield alveolar-like macrophages.
    Type: Application
    Filed: August 9, 2017
    Publication date: November 23, 2017
    Inventors: Martin Post, Michael Litvack