Abstract: A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample with a target protein, generating a second image of the biological sample with a target nucleic acid sequence, and generating a composite image that provides the relative locations of both the target protein and the target nucleic acid sequence. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are systems and kits that comprise the means for executing the novel methods.

Abstract: Methods for selective inhibition control in semiconductor manufacturing are provided. An example method includes providing a substrate including a feature having one or more feature openings and a feature interior. A nucleation layer is formed on a surface of the feature interior. Based on a differential inhibition profile, a nonconformal bulk layer is selectively formed on a surface of the nucleation layer to leave a region of the nucleation layer covered, and a region of the nucleation layer uncovered by the nonconformal bulk layer. An inhibition layer is selectively formed on the covered and uncovered regions of the nucleation layer. Tungsten is deposited in the feature in accordance with the differential inhibition profile.

Abstract: A method includes determining, based on an image having an initial viewpoint, a depth image, and determining a foreground visibility map including visibility values that are inversely proportional to a depth gradient of the depth image. The method also includes determining, based on the depth image, a background disocclusion mask indicating a likelihood that pixel of the image will be disoccluded by a viewpoint adjustment. The method additionally includes generating, based on the image, the depth image, and the background disocclusion mask, an inpainted image and an inpainted depth image. The method further includes generating, based on the depth image and the inpainted depth image, respectively, a first three-dimensional (3D) representation of the image and a second 3D representation of the inpainted image, and generating a modified image having an adjusted viewpoint by combining the first and second 3D representation based on the foreground visibility map.

Abstract: An open application protocol for industrial equipment is disclosed. Disclosed techniques include: opening a connection between (a) an open application associated with a manufacturing execution system and (b) an instance of a data sharing interface operating on an industrial machine used in a surface mounting process, the open application being configured to communicate with any machine that implements the data sharing interface, regardless of machine type or manufacturer; discovering, by the open application via the connection, discoverable information associated with the industrial machine, the discoverable information including one or more of data items, events, commands, or alarms; and controlling, by the open application via the connection, operation of the industrial machine to control at least a portion of the surface mounting process.

Abstract: A case assembly selectively encases and displays a mobile communications device. The case assembly includes or incorporates a segmented cradle assembly configured to adjustably cradle variously sized mobile communications devices. The segmented cradle assembly includes an anterior panel, a posterior panel, and a plurality of device-holding cradle segments. Each device-holding cradle segment includes a panel-opposing portion and a device-cradling portion. The anterior panel is spaced from the posterior panel, and the panel-opposing portions are loosely sandwiched intermediate the anterior panel and the posterior panel. The panel-opposing portions are further attached to the panels by way of an elastic tether member. The cradle segments are displaceable relative to the panels and to one another via the elastic tether members for varying a distance between the device-holding cradle segments thereby being adjustable for receiving and cradling variously sized mobile communications devices.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Disclosed in certain embodiments are polymer compositions comprising a hybrid metal oxide particles and methods of preparing the same. In at least one embodiment, hybrid metal oxide particles comprise a continuous matrix of a first metal oxide having embedded therein an array of metal oxide particles comprising a second metal oxide. In at least one embodiment, the hybrid metal oxide particles are substantially non-porous.

Abstract: Disclosed in certain embodiments are polymer compositions comprising closed-cell metal oxide particles and methods of preparing the same. In at least one embodiment, a closed-cell metal oxide particle comprises a metal oxide matrix defining an array of closed-cells. Each closed-cell encapsulates a media-inaccessible void volume. The outer surface of the closed-cell metal oxide particle is defined by the array of closed-cells.

Abstract: Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Described herein are systems and methods for improving light-sheet microscopy with cost-effective and simplified components. Such cost-effective and simplified components can be implemented in a light focusing system, a light generation system, and/or in imaging system. The light focusing system can be improved by attaching a voice coil motor to a focusing lens to increase the imagable field of view. The light generation system can be improved with a multimode laser diode to increase the uniformity of the beam profile and to increase the usable optical power. The imaging system can be improved by using a fluid chamber with positive cylindrical optical window for minimizing spherical aberrations.

Abstract: Methods of generating a mobility assessment for a subject are provided. Aspects of the methods include: instructing the subject to perform an activity including an oscillatory motion; generating a visual recording of the subject performing the activity using a recording device; extracting time series data from the visual recording using a dynamic algorithm; generating one or more musculoskeletal movement biomarkers from the time series data; and producing the mobility assessment for the subject from the one or more musculoskeletal movement biomarkers. Also provided are systems for use in practicing methods of the invention.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Abstract: Methods of lowering blood glucose and treating Type 2 diabetes in a subject by increasing expression or activity of phosphodiesterase 4D isoform 3 (PDE4D3) in adipocytes of the subject are described. In some instances, expression of PDE4D3 in adipocytes is increased by administering a vector that expresses PDE4D3 specifically in adipocytes, or via gene editing by introduction of a PDE4D3-encoding nucleic acid into adipocytes. Use of small molecule activators of PDE4D3 that are targeted to adipocytes is also described.

Abstract: A scattering-type scanning near-field optical microscope at cryogenic temperatures (cryo-SNOM) configured with Akiyama probes for studying low energy excitations in quantum materials present in high magnetic fields. The s-SNOM is provided with atomic force microscopy (AFM) control, which predominantly utilizes a laser-based detection scheme for determining the cantilever tapping motion of metal-coated Akiyama probes, where the cantilever tapping motion is detected through a piezoelectric signal. The Akiyama-based cryo-SNOM attains high spatial resolution, good near-field contrast, and is able to perform imaging with a significantly more compact system capable of handling simultaneous demands of vibration isolation, low base temperature, precise nano-positioning, and optical access. Results establish the potential of s-SNOM based on self-sensing piezo-probes, which can easily accommodate near-IR and far-infrared wavelengths and high magnetic fields.

Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

Abstract: A system includes a dynamic compressor and a controller having a processor and a memory. The compressor includes a first compressor stage having a first variable inlet guide vane (VIGV) and a second compressor stage having a second VIGV. The memory stores instructions that program the processor to operate the compressor at a current speed, a first position of the first VIGV, and a second position of the second VIGV to compress the working fluid, and to determine if a condition is satisfied. If the condition is not satisfied, the processor is programmed to continue to operate the compressor at the current speed, the first position of the first VIGV, and the second position of the second VIGV. If the condition is satisfied, the processor is programmed to change the second position of the second VIGV to a third position and maintain the first position of the first VIGV.

Abstract: The disclosed technology addresses the need in the art to enable users to broadcast a status that indicates that a user is inviting others to join their livestream, such that they are either prepared to livestream or is livestreaming. An invite-to-join status may be limited to the specific friends and community members of the user's choosing. If the user has no viewer yet, the user will not broadcast a livestream and will continue with what they are doing, such as playing a game or watching a movie. Once a first viewer joins, then the user screen may be broadcasted into a livestream.

Abstract: A computer-implemented method to send targeted messages based on a driver's intent. The method includes identifying, by a sending vehicle, one or more additional vehicles in the vicinity of the sending vehicle, including a first vehicle. Monitoring a set of data related to a current scenario for the sending vehicle and determining, based on a current scenario, an intent score for the sending vehicle. The method includes activating a horn device associated with the sending vehicle. The method further includes determining, in response to the activating, the intent score is above an intent threshold for the first vehicle. The method includes generating, in response to the intent score being above the intent threshold, a message; and sending, to a target vehicle, the message. Further aspects of the present disclosure are directed to systems and computer program products containing functionality consistent with the method described above.

Abstract: Tamper-proof gateways are described. A gateway comprises a date intake module, a data transmission module, a tamper switch and a controller. The data intake module couples to one or more data generation devices. The data transmission module is configured to transmit sense information generated by the one or more data generation devices to a network. The tamper switch is configured to generate an alert signal in response to sensing tampering of the tamper-proof gateway. The controller is configured to: 1) place the tamper-proof gateway in a secure state in response to receiving the alert signal from the tamper switch, and 2) withdraw the tamper-proof gateway from the secure state in response to receiving authentication information. Withdrawing the gateway from the secure state may comprise placing the tamper-proof gateway in a first privileged state or a second privileged state.