Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A system, method, and computer-readable medium for determining a root cause for a failure event. A failure of a product or system triggers a failure event. When the failure event is triggered, querying by one or more ML/DL path root cause engines is performed on stored failure incident data sets. The queried failure incident data sets are listed and ranked. Based on the ranking, a root cause is determined as to the failure event.

Abstract: Example data transmission methods and apparatus are described. One example method includes: An access point sends first indication information to a first station, where the first indication information indicates that the first station is accepted to obtain sensing information of a second station. The access point sends the sensing information of the second station to the first station, where the access point is a proxy of the first station, the proxy is configured to obtain the sensing information of the second station for the first station, the first station is a sensing by proxy (SBP) requesting station, and the second station is a SBP responding station.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Disclosed herein is a personal care composition. In particular, disclosed herein is a substantially anhydrous personal care composition comprising at least one non-volatile emollient oil having a boiling point of at least 215° C. at atmospheric pressure, a lipophilic material, and less than 25% antiperspirant active by weight of the composition, wherein the composition has reduced volatile silicones, and further wherein the composition is substantially free of emulsifier. The disclosed personal care composition is especially useful as an efficacious antiperspirant or deodorant stick with reduced volatile silicone content that provides parity payout and sensory benefits upon topical application to skin.

Abstract: In one embodiment, a method includes receiving a first user input from a first user, wherein the first user input comprises a partial request, presenting one or more suggested intent auto-completions corresponding to the partial request, receiving a selection by the first user of a first suggested intent auto-completion of the suggested intent auto-completions and a second user input, presenting one or more suggested slot auto-completions corresponding to one or more candidate slot-hypotheses corresponding to the second user input, respectively, wherein each of the candidate slot-hypotheses comprise a slot-suggestion, and wherein each suggested slot auto-completion comprises the second user input and the corresponding candidate slot-hypothesis, receiving a selection by the first user of a first suggested slot auto-completion of the suggested slot auto-completions, and presenting execution results of one or more tasks corresponding to the first suggested intent auto-completion and the first suggested slot auto

Abstract: A microwave includes an external enclosure having a top surface that defines a cooling air inlet and a cooling air outlet along a front edge thereof. An internal enclosure defines a cooking cavity within the external enclosure. A sidewall of the internal enclosure defines a first air passage, and a top wall of the internal enclosure defines a second air passage. A cooking component area is defined between the internal enclosure and the external enclosure adjacent the sidewall of the internal enclosure. A cooling fan is disposed within the cooking component area. The cooling fan is configured to direct air along a cooling air path from the cooling air inlet, through the cooking component area, through the cooking cavity, and to the cooling air outlet.

Abstract: The present disclosure provides autonomous vehicle systems and methods that include or otherwise leverage a motion planning system that generates constraints as part of determining a motion plan for an autonomous vehicle (AV). In particular, a scenario generator within a motion planning system can generate constraints based on where objects of interest are predicted to be relative to an autonomous vehicle. A constraint solver can identify navigation decisions for each of the constraints that provide a consistent solution across all constraints. The solution provided by the constraint solver can be in the form of a trajectory path determined relative to constraint areas for all objects of interest. The trajectory path represents a set of navigation decisions such that a navigation decision relative to one constraint doesn't sacrifice an ability to satisfy a different navigation decision relative to one or more other constraints.

Abstract: A heat transfer system to alternatively and/or simultaneously provide heating and cooling in a mobile vehicle that includes an electrical power source requiring heating and/or cooling during charging and/or operation and that includes a cabin that requires heat input during low temperature ambient conditions.

Abstract: The present application relates to substituted dyes containing bis-boron fused heterocycles and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

Abstract: A process for preparing cyanoethyltrimethoxysilane is performed via transesterification of cyanoethyltriethoxysilane with methanol in the presence of a catalyst. The cyanoethyltrimethoxysilane is useful as an adhesion promoter, a coupling agent, or a crosslinker. The cyanoethyltrimethoxysilane may be formulated in a polyorganosiloxane sealant composition.

Abstract: Emobidments of a curved glass article are disclosed herein. The curved glass article includes a glass sheet first and second major surfaces. The glass sheet is bent to define a curved region disposed between flat sections. The curved glass article also includes a carrier adhered to the glass sheet. The carrier includes longitudinal strips and lateral strips. The longitudinal strips define the radius of curvature of the curved region. The lateral strips extend between the longitudinal strips. The glass sheet deviates 0.3 mm or less from planar in the flat sections. The longitudinal strips each have a width Wlong of 2 mm or less. The first lateral strips each have a width Wlat of 20 mm or less. At least a portion of the width Wlat of each lateral strip is located in the curved region and a flat section.

Abstract: Embodiments of the present invention provide an acrylate-functionalized polysiloxane-bisphenol A polyether block copolymer for use as a toughener with thermosetting resins.

Abstract: The present disclosure generally relates to spin-orbit torque (SOT) magnetic tunnel junction (MTJ) devices comprising a doped bismuth antimony (BiSbE) layer having a (012) orientation. The devices may include magnetic write heads, read heads, or MRAM devices. The dopant in the BiSbE layer enhances the (012) orientation. The BiSbE layer may be formed on a texturing layer to ensure the (012) orientation, and a migration barrier may be formed over the BiSbE layer to ensure the antimony does not migrate through the structure and contaminate other layers. A buffer layer and interlayer may also be present. The buffer layer and the interlayer may each independently be a single layer of material or a multilayer of material. The buffer layer and the interlayer inhibit antimony (Sb) migration within the doped BiSbE layer and enhance uniformity of the doped BiSbE layer while further promoting the (012) orientation of the doped BiSbE layer.

Abstract: A system for predicting subject enrollment for a study includes a time-to-first-enrollment (TTFE) model and a first-enrollment-to-last-enrollment (FELE) model for each site in the study. The TTFE model includes a Gaussian distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression, and the FELE model includes a negative binomial distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression estimation.

Abstract: Systems, devices, and methods are provided for depth-guided structure from motion. A system may obtain a plurality of image frames from a digital content item that corresponds to a scene and determine, based at least in part on a correspondence search, a set of 2-D keypoints for the plurality of image frames. A depth estimator may be used to determine a plurality of dense depth map for the plurality of image frames. The set of 2-D keypoints and the plurality of dense depth maps may be used to determine a corresponding set of depth priors. Initialization and/or depth-regularized optimization may be performed using the keypoints and depth priors.

Abstract: A size of an optical aperture for an imaging system is adjustable. The size of the optical aperture can be adjusted based on refractive index matching, optical absorption, or near field coupling techniques. These techniques may also be used to provide a high speed optical shutter.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.