Abstract: A method of reducing convulsive seizure frequency in a human patient diagnosed with Dravet syndrome, comprising administering to the patient a therapeutically effective dose of fenfluramine or a pharmaceutically acceptable salt, base, acid or amine thereof, and repeating the administering over a period of days until the patient exhibits a significant reduction (e.g., 40% or greater) from baseline in convulsive seizure frequency. In some embodiments of the method, convulsive seizures are completely eliminated for 10 days or more, 20 days or more, 30 days or more, 50 days or more, 100 days or more.

Abstract: A method of reducing convulsive seizure frequency in a human patient diagnosed with Dravet syndrome, comprising administering to the patient a therapeutically effective dose of fenfluramine or a pharmaceutically acceptable salt, base, acid or amine thereof, and repeating the administering over a period of days until the patient exhibits a significant reduction (e.g., 40% or greater) from baseline in convulsive seizure frequency. In some embodiments of the method, convulsive seizures are completely eliminated for 10 days or more, 20 days or more, 30 days or more, 50 days or more, 100 days or more.

Abstract: A method of increasing an average time between seizures in a human patient diagnosed with Dravet syndrome, comprising administering to the patient a therapeutically effective dose of fenfluramine or a pharmaceutically acceptable salt, base, acid or amine thereof, and repeating the administering over a period of days until the patient exhibits an increase from baseline in average time between convulsive seizures of 6 hours, days weeks or more.

Abstract: An air cleaning element comprises a generally rectangular frame comprising a first two opposing sides and a second two opposing sides; a plurality of rods supported on and extending between the first two opposing sides, wherein each rod is offset from its two adjacent rods; and a wire mesh sheet that is generally rectangular and corrugated around the plurality of rods. The sheet extends to and between the two opposing sides.

Abstract: A method of varying the power output of a transmitter. The method includes providing bit-loading information associated with each tone of multiple tones, where the multiple tones include a first set of tones. The method also includes producing, for transmission, on the first set of tones a first set of constellation symbols based upon the bit-loading information. The method also includes producing a second set of constellation symbols for transmission, where there is a difference of n bits between the bit size of the second bit sequence constellation symbol on each tone of the second set of tones and the bit-loading information associated with each tone of the first set of tones, and where n is an integer greater than or equal to 0.

Abstract: A method of synchronizing a receiver with a transmitter. The method includes determining number of bits, j, for adjusting a bit stream, where the bit stream is generated from n tones and is dividable into codewords having a codeword length of N bytes, and the number of bits for adjusting the bit stream is determined based upon n and N. The method includes detecting a loss of synchronization indication. In response to detection of the loss of synchronization indication, the method includes adjusting the bit stream by j bits. The method includes determining whether synchronization has been regained. When synchronization has not been regained, the method includes adjusting the bit stream again by j bits. When synchronization has been regained, the method includes terminating adjustment of the bit stream.

Abstract: A method of varying the power output of a transmitter. The method includes providing bit-loading information associated with each tone of multiple tones, where the multiple tones include a first set of tones. The method also includes producing, for transmission, on the first set of tones a first set of constellation symbols based upon the bit-loading information. The method also includes producing a second set of constellation symbols for transmission, where there is a difference of n bits between the bit size of the second bit sequence constellation symbol on each tone of the second set of tones and the bit-loading information associated with each tone of the first set of tones, and where n is an integer greater than or equal to 0.

Abstract: A method of synchronizing a receiver with a transmitter. The method includes determining number of bits, j, for adjusting a bit stream, where the bit stream is generated from n tones and is dividable into codewords having a codeword length of N bytes, and the number of bits for adjusting the bit stream is determined based upon n and N. The method includes detecting a loss of synchronization indication. In response to detection of the loss of synchronization indication, the method includes adjusting the bit stream by j bits. The method includes determining whether synchronization has been regained. When synchronization has not been regained, the method includes adjusting the bit stream again by j bits. When synchronization has been regained, the method includes terminating adjustment of the bit stream.

Abstract: A system and method for reordering tones of a DMT signal within a communication system is described. Cross tone correlated noise in a received signal is identified and rearranged such that tones with correlated noise are spread out throughout the received signal before being processed by a decoder such as, Viterbi decoder. In an embodiment, two tones with the most correlated noise are placed at each end of the sequence of tones presented to the Viterbi decoder. In some embodiment, the tones with correlated noise can be spread such that two adjacent tones with correlated noise have a minimum distance of at least three tones between them at the input to the Viterbi decoder. In other embodiment, tones in the received signal can be processed in various kinds of interleavers for reordering according to the interleaver scheme.

Abstract: A receiver architecture featuring a decimation filter and a bypass around said decimation filter is disclosed along with a method for optimizing said receiver's sampling phase and programmable gain amplifier. Said method utilizes said receiver architecture to modify said receiver's receive path to simplify optimizations.

Abstract: A compliant spacer which, in use, is located between planar surfaces of two machine elements which are, in use, clamped together in an assembly, the spacer having a first generally planar face and a second oppositely facing generally planar face which is generally parallel to the first generally planar face, each of the first and second generally planar faces having a plurality of raised regions, the raised regions of the first face being offset with respect to the raised regions of the second face, so that as the two machine elements are clamped together with the spacer therebetween, the spacer deforms out of plane to maintain the clamping load in use, and each raised region including a bearing surface and edge regions where the raised region joins the respective planar face of the spacer, the bearing surface being generally planar and parallel to the first and second planar faces, and the edge regions of the raised regions melding smoothly into the respective planar face of the spacer without any sharp disc

Abstract: Modem selection of Reed-Solomon codeword configuration to maximize error-corrected data rate given channel analysis. A lookup table of maximal codeword size given parity bytes and channel MSE allows precomputation.

Abstract: A receiver architecture featuring a decimation filter and a bypass around said decimation filter is disclosed along with a method for optimizing said receiver's sampling phase and programmable gain amplifier. Said method utilizes said receiver architecture to modify said receiver's receive path to simplify optimizations.

Abstract: A thermoplastic elastomeric material comprising a hydrogenated copolymer of a conjugated diene characterised in that the copolymer before hydrogenation is a random copolymer of 70 to 99 mole % of at least one conjugated diene and 30 to 1 mole % of at least one vinyl aromatic compound, is of number average molecular weight of at least 100,000, and has a vinyl content of at most 40 mole % based on total monomers, and in that the copolymer is hydrogenated to an extent such that the mole percentage saturation is in the range 40 to 90%.