Patents by Inventor Michael Loken

Michael Loken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting and confirming minimal disease
    Publication number: 20070020670
    Abstract: The present invention provides improved methods for detection of minimal disease. More specifically, the invention provides methods for combining cell sorting with clonality profiling to effectively lower sensitivity limits for disease detection and to provide independent confirmation of the tumor detection without the need for patient specific assay designs.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 25, 2007
    Applicant: HematoLogics, Inc.
    Inventors: Michael Loken, Barbara Zehentner-Wilkinson
  • Functional multi-drug resistance assay
    Publication number: 20060263834
    Abstract: The invention provides methods for determining multi-drug resistance activity of a tumor cell that is present in a heterogeneous mixture of normal cells. The present invention relates particularly to improved quantitative methods for characterizing multi-drug resistance of selected populations of cells, including hematopoietic cell populations containing malignant cells. More specifically, the invention provides flow immunocytometric methods for determining whether malignant hematopoietic cells are resistant to a chemotherapeutic drug and for identifying agents that inhibit multi-drug resistance activity in the malignant cells.
    Type: Application
    Filed: February 24, 2006
    Publication date: November 23, 2006
    Applicant: HematoLogics, Inc.
    Inventor: Michael Loken
  • System, method, and article for detecting abnormal cells using multi-dimensional analysis
    Publication number: 20060263833
    Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.
    Type: Application
    Filed: February 17, 2006
    Publication date: November 23, 2006
    Applicant: HematoLogics, Inc.
    Inventors: Michael Loken, Sanjaya Joshi
  • Method for collecting purified cells
    Publication number: 20060234275
    Abstract: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized.
    Type: Application
    Filed: March 28, 2006
    Publication date: October 19, 2006
    Applicant: HematoLogics, Inc.
    Inventor: Michael Loken
  • Method for collecting purified cells
    Publication number: 20050233362
    Abstract: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized.
    Type: Application
    Filed: March 30, 2005
    Publication date: October 20, 2005
    Applicant: HematoLogics, Inc.
    Inventor: Michael Loken
  • Method and device for producing extreme ultraviolet radiation and soft x-ray radiation
    Publication number: 20040183037
    Abstract: A method for generating extreme ultraviolet radiation and soft x-ray radiation with a gas discharge operated on the left branch of the Paschen curve, in particular, for EUV lithography,
    Type: Application
    Filed: March 26, 2004
    Publication date: September 23, 2004
    Inventors: Jurgen Klein, Willi Neff, Stefan Seiwert, Klaus Bergmann, Joseph Pankert, Michael Loken