Abstract: Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Abstract: Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Abstract: A device for intravascular intervention can comprise an intervention element and an elongate manipulation member. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The hooked portion can have a first segment, a second segment, and a bend between the first and second segments, with the first segment and the second segment located on different sides of the intervention element. At least one of the first segment or the second segment can have an extending portion that extends into a region that is (i) between a top side and a bottom side of the intervention element, and (ii) distal to a proximal part of the intervention element. The extending portion and the proximal part can be aligned such that a line extending in a proximal-distal direction intersects the extending portion and the proximal part.

Abstract: A self-expanding stent includes a proximal portion having a first cross-sectional area in an expanded state, a distal portion having a second cross-sectional area in an expanded state, a narrowed portion between the proximal portion and the distal portion, the narrowed portion comprising a cross-sectional area when in an expanded state that is less than the first cross-sectional area and the second cross-sectional area, wherein the narrowed portion is configured to increases flow velocity in the narrowed portion while reducing reduce pressure against a distal wall of the aneurysm by being axially disposed substantially between a proximal edge and a distal edge of an aneurysm neck or ostium, the flow traversing through the lumen of the self-expanding stent. In use, the self-expanding stent is positioned at the site of an aneurysm and expanded via release from a stent delivery device.

Abstract: An intravascular intervention system can include a manipulation member sized for insertion into a blood vessel and an intervention member coupled to the manipulation member. The manipulation member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length. The intervention member can be compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and be self-expandable from the collapsed configuration to an expanded configuration.

Abstract: An aneurysm therapy system, can include a catheter and an occlusive device. The catheter can have a proximal end, a distal end, and a lumen extending between the proximal and distal ends. The proximal end can include a self-expanding distal section, and the distal section can comprise a coil portion. The occlusive device can be disposed within the lumen and configured to reside in the aneurysm to restrict fluid flow within the aneurysm.

Abstract: A device for intravascular intervention can comprise an intervention element and an elongate manipulation member. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The hooked portion can have a first segment, a second segment, and a bend between the first and second segments, with the first segment and the second segment located on different sides of the intervention element. At least one of the first segment or the second segment can have an extending portion that extends into a region that is (i) between a top side and a bottom side of the intervention element, and (ii) distal to a proximal part of the intervention element. The extending portion and the proximal part can be aligned such that a line extending in a proximal-distal direction intersects the extending portion and the proximal part.

Abstract: A device for intravascular intervention can comprise an intervention element, an elongate manipulation member, and a joining element. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The joining element can substantially permanently attach the hooked portion to the intervention element.

Abstract: Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: A medical device is provided that includes a vessel-engaging member attached to a distal end of a delivery wire. The vessel-engaging member includes a plurality of rows, with each row having a plurality of struts arranged in an alternating pattern such that for each row, a first set of vertices is positioned on a proximal side, and a second set of vertices is positioned on a distal side. The vessel-engaging member further includes a plurality of single bridges positioned between adjacent rows, each of the bridges connecting a vertex of a first row with a corresponding vertex of an adjacent second row. The vessel-engaging member can also include a plurality of double bridges positioned between adjacent rows, each of the double bridges connecting a vertex of a first row with two adjacent vertices of an adjacent second row.

Abstract: A vascular remodeling device and methods for its use are provided. The device can be positionable at a junction of a bifurcation having an aneurysm and that defines afferent and efferent vessels. Ends of the device can be at least partially inserted into the aneurysm or can anchor the device by being at least partially inserted into efferent vessels. The device can act as a scaffolding to inhibit dislodging of objects out of the aneurysm. The device can permit perfusion to the efferent vessels. Embolic material can be inserted in the aneurysm before, during, and/or after positioning the device.

Abstract: An intraluminal device may be used at a bifurcation to anchor in an afferent vessel, allow perfusion to efferent vessels, and act as scaffolding to inhibit herniation of objects out of a neck of a bifurcation aneurysm. An intraluminal device may include a first side; a second side opposite the first side across a longitudinal axis of the intraluminal device; a proximal section configured to anchor in an afferent vessel; a distal section comprising a first wing and a second wing wherein, in an expanded state, the first wing extends from the first side to the second side and the second wing extends from the second side, through an opening of the first wing, and to the first side.

Abstract: An intravascular intervention system can include a manipulation member sized for insertion into a blood vessel and an intervention member coupled to the manipulation member. The manipulation member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length. The intervention member can be compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and be self-expandable from the collapsed configuration to an expanded configuration.

Abstract: A medical device is provided. The medical device includes a vessel-engaging member attached to a distal end of a delivery wire via a connection mechanism. The vessel-engaging member includes a plurality of rows and a plurality of bridges positioned between each adjacent row, each of the bridges connecting a vertex of a first row with a corresponding vertex of a second row. The vessel-engaging member further includes first and second tapered sections coupled to the connection mechanism, each of the tapered sections projecting from a proximal row and tapering in a direction from the proximal row toward the connection mechanism, each of the tapered sections having a length measured along a longitudinal axis, wherein the length of the first tapered section is less than the length of the second tapered section.

Abstract: A stent delivery system can include an elongate core member sized for insertion into a blood vessel. The core member can be configured to advance a stent toward a treatment location in the blood vessel. The core member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Abstract: A stent delivery system can include an elongate core member sized for insertion into a blood vessel. The core member can be configured to advance a stent toward a treatment location in the blood vessel. The core member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Abstract: Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Abstract: Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: A self-expanding stent includes a proximal portion having a first cross-sectional area in an expanded state, a distal portion having a second cross-sectional area in an expanded state, a narrowed portion between the proximal portion and the distal portion, the narrowed portion comprising a cross-sectional area when in an expanded state that is less than the first cross-sectional area and the second cross-sectional area, wherein the narrowed portion is configured to increases flow velocity in the narrowed portion while reducing reduce pressure against a distal wall of the aneurysm by being axially disposed substantially between a proximal edge and a distal edge of an aneurysm neck or ostium, the flow traversing through the lumen of the self-expanding stent. In use, the self-expanding stent is positioned at the site of an aneurysm and expanded via release from a stent delivery device.

Abstract: An intraluminal device may be used at a bifurcation to anchor in an afferent vessel, allow perfusion to efferent vessels, and act as scaffolding to inhibit herniation of objects out of a neck of a bifurcation aneurysm. An intraluminal device may include a first side; a second side opposite the first side across a longitudinal axis of the intraluminal device; a proximal section configured to anchor in an afferent vessel; a distal section comprising a first wing and a second wing wherein, in an expanded state, the first wing extends from the first side to the second side and the second wing extends from the second side, through an opening of the first wing, and to the first side.