Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: A method for providing a user agent (UA) with service identification data. The method includes an application server (AS) transmitting Session Initiation Protocol (SIP) data. The SIP data comprises an identifier of the AS and a service identifier for at least one service supported by the AS. The method further includes the UA receiving the SIP data.

Abstract: A method for performing initial registration is provided. The method includes receiving a server timeout message, the server timeout message including at least a field set to a value equal to a value received during a first registration. The method further includes initiating restoration procedures by performing an initial registration.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: The present disclosure involves systems, software, and computer implemented methods for automatically providing a lending offer for loyalty points based on a customer account analysis. One example method includes initiating an offer analysis for a customer account associated with a particular customer and storing an account balance and a point deficit balance. The offer analysis determines whether to provide an offer for a point loan, and is based on profile information of the customer, a current point balance, and a reward identified from the loyalty account. If an offer is to be provided, an offer for a loan of points equal to the difference between the current point balance of a loyalty account and the point value cost of the reward is transmitted to a client device of the customer. If accepted, the current point balance and the point deficit are both incremented by the amount of the offer.

Abstract: Disclosed is a buttock support for at least partial load-relief of the body weight of a person, the buttock support having two support regions adapted to receive at least part of a buttock region of the person. Also disclosed is a load-relief system having the aforementioned buttock support. The two support regions are separated from one another by a gap and are rounded. The gap separates the two support regions from one another centrally. The buttock support significantly simplifies the connection of a person to the aforementioned load-relief system to prepare for manual and/or automated physical therapy and also ensures that the thigh region, in particular the inner face of the thigh, and the groin region are accessible for further medical/therapeutic treatment by the medical staff.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: An aircraft includes a fuselage, a main entry door with an associated passenger loading zone, an auxiliary power unit (APU) in the fuselage, and an APU inlet assembly. The APU inlet assembly has an inlet duct, and inlet door, and means for redirecting sound waves coupled to or integrated with an interior side of the inlet door. The inlet duct has a first end coupled to the APU, and a second end associated with the inlet door. The inlet door moves between a closed position and an open position. The means for redirecting sound waves is positioned at a particular location on the interior side of the inlet door, and includes certain acoustic features and characteristics. The particular location and the acoustic features and characteristics cooperate to redirect sound waves generated by the APU away from the passenger loading zone when the inlet door is in the open position.

Abstract: A valve includes a valve body having a valve plunger barrel formed therein and configured to be mounted to a pump head of a fuel pump, a valve plunger arranged to perform reciprocal motion with respect to the valve plunger barrel, a drive assembly configured to cause the valve plunger to perform reciprocal motion, and a spacer configured to couple to the valve plunger to perform reciprocal motion together with the valve plunger and configured to interface with the pump head. The spacer has a spacer body with first and second opposing spacer surfaces and with a central aperture extending from the first to the second spacer surface and configured to receive the valve plunger therethrough. At least one of the first and second spacer surfaces includes one or more grooves recessed into the spacer body to reduce or inhibit cavitation of the interface of the spacer and pump head.

Abstract: A pump inlet valve includes a valve body and a plunger assembly. The valve body includes a valve body cavity. The plunger assembly is arranged within the valve body cavity and includes a plunger body, a plunger barrel formed at the plunger body so as to form a plunger barrel volume, and a plunger. The plunger is configured to move within the plunger barrel to thereby allow a fluid to flow past the plunger assembly when the plunger is in an open position and to inhibit the fluid from flowing past the plunger assembly when the plunger is in a closed position. The plunger is configured to allow continuous fluid communication between the plunger barrel volume and a supply inlet, through which fluid is supplied to the pump inlet valve.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: Apparatuses for immobilizing fuel injection apparatuses are disclosed. A coupling member couples a fuel injection apparatus with an injector body of an engine. The coupling member includes a top surface, a bottom surface, a side surface, and an opening extending from the top surface to the bottom surface. The opening receives the fuel injection apparatus. The coupling member also includes a protruding portion extending from the bottom surface or the side surface which comes into contact with the injector body to prevent rotational movement of the fuel injection apparatus.

Abstract: Process control systems for operating process plants are disclosed herein. The process control systems include control modules that are decoupled from the I/O architecture of the process plants using signal objects or generic shadow blocks. This decoupling is effected by using the signal objects or generic shadow blocks to manage at least part of the communication between the control modules and the field devices. Signal objects may convert between protocols used by control modules and field devices, thus decoupling the control modules from the I/O architecture. Generic shadow blocks may be automatically configured to mimic the operation of field devices within a controller executing the control modules, thus partially decoupling the control modules from the I/O architecture by using the shadow blocks to manage communication between the control modules and the field devices.

Abstract: The present disclosure provides a fuel injector, comprising: a body including a plurality of body alignment features; a nozzle including a plurality of nozzle alignment features and a plurality of nozzle holes for injecting fuel; and a plurality of alignment guides configured to mate with the plurality of body alignment features and the plurality of nozzle alignment features to align the nozzle with the body such that the plurality of nozzle holes is in a desired orientation relative to the body.

Abstract: A sock having a foot bed configured to expand at least two sizes on the National Association of Hosiery Manufacturers (NAHM) sock size measuring system while comfortably accommodating the foot of the wearer. The body portion and foot bed are mesh knit substantially entirely on the same needle cylinder using heavier body yarns, lighter denier nylon fibers and/or stronger spandex fibers than is typical for manufacturing socks.

Abstract: Aircraft, vibration isolation assemblies, and methods of assembling vibration isolation assemblies are provided. An aircraft includes a vibration isolation assembly. The vibration isolation assembly includes a mounting track, a plate, a clamp block, a vibration isolator, and a support fitting. The mounting track defines a cavity and includes flanges that define an opening to the cavity. The plate is configured to be positioned on the flanges outside of the cavity. The clamp block is configured to be fastened to the plate under the flanges of the mounting track within the cavity. The vibration isolator is configured to be laterally constrained by the clamp block within the cavity. The support fitting is configured to be secured to the vibration isolator outside of the cavity.

Abstract: A method for determining whether a patient may be enrolled into a clinical trial includes the steps of examining the patient's medical record from an electronic health record system, deriving a plurality of first concepts from the medical record, normalizing each concept in the plurality of first concepts to produce, for each normalization, a normalized concept, comparing each normalized concept to a list of study criteria, to indicate if the normalized concept meets the criteria, and if each criteria is met, indicating that the patient is not ineligible for enrollment in the clinical trial

Abstract: A method includes the steps of determining a first concept from a text of a medical record from an electronic health record system, the first concept relating to a patient, identifying a match to the first concept in a first list of concepts, wherein the first list of concepts is not a predetermined authority, referencing the first concept with an entity in a database of related concepts, identifying a match to a second concept in a second list of concepts, the second list of concepts not directly linked to the first list of concepts except by a relationship to the entity, wherein the second list of concepts is the predetermined authority, and providing the second concept as an identifier of the patient's medical record.

Abstract: Techniques for streaming big data in a process plant are disclosed. Generally, these techniques facilitate storage or communication of process control data, including alarms, parameters, events, and the like, in near real-time. Receivers of big data, such as big data historians or devices requesting specific data, are configured via an initial set of metadata, and thereafter receive updated metadata upon requesting it from the transmitting device, such as when the receiving device encounters an identifier in the data, which identifier was not defined in the metadata previously received.