Patents by Inventor Michael Luethy
Michael Luethy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240079092Abstract: Systems and methods for subject clinical condition evaluation using a plurality of modules are provided. Modules comprise features whose corresponding feature values associate with an absence, presence or stage of phenotypes associated with the clinical condition. A first dataset is obtained having feature values, acquired through a first technical background from respective subjects in transcriptomic, proteomic, or metabolomic form, for at least a first of the plurality of modules. A second training dataset is obtained having feature values, acquired through a technical background other than the first technical background, from training subjects of the second dataset, in the same form as for the first dataset, of at least the first module. Inter-dataset batch effects are removed by co-normalizing feature values across the training datasets, thereby calculating co-normalized feature values used to train a classifier for clinical condition evaluation of the test subject.Type: ApplicationFiled: November 6, 2023Publication date: March 7, 2024Inventors: Michael B. Mayhew, Ljubomir Buturovic, Timothy E. Sweeney, Roland Luethy, Purvesh Khatri
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Publication number: 20070118918Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: May 24, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizz, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070118917Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: May 24, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizz, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070113302Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: May 17, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizz, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070094748Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 26, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089187Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089194Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089192Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089193Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089184Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089195Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089185Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089188Abstract: The present invention provides molecular consrtucts and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089186Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089191Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbetson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089189Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Hovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089190Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070089196Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 19, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070083952Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 12, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizz, Yuanji Zhang, Liang Guo, Linda Lutfiyya
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Publication number: 20070083950Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: October 10, 2006Publication date: April 12, 2007Inventors: Shihshieh Huang, Thomas Malvar, Michael Luethy, Philip Miller, Larry Gilbertson, Edwards Allen, Sara Heisel, David Kovalic, James Roberts, Nancy Houmard, Alessandra Frizzi, Yuanji Zhang, Liang Guo, Linda Lutfiyya