Patents by Inventor Michael Luzzio

Michael Luzzio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260226061
    Abstract: The present application discloses compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such as Spinocerebellar Ataxia 3 (SCA3 or Machado-Joseph Disease).
    Type: Application
    Filed: January 18, 2024
    Publication date: August 6, 2026
    Inventors: Hasane RATNI, Ingo KONETZKI, Brian LUCAS, Michael LUZZIO
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260226062
    Abstract: The present application discloses compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such as Spinocerebellar Ataxia 3 (SCA3 or Machado-Joseph Disease).
    Type: Application
    Filed: January 18, 2024
    Publication date: August 6, 2026
    Inventors: Hasane RATNI, Ingo KONETZKI, Brian LUCAS, Michael LUZZIO
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260224583
    Abstract: The present application discloses compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such as Spinocerebellar Ataxia 3 (SCA3 or Machado-Joseph Disease).
    Type: Application
    Filed: January 18, 2024
    Publication date: August 6, 2026
    Inventors: Hasane RATNI, Ingo KONETZKI, Brian LUCAS, Michael LUZZIO
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260217720
    Abstract: The present application discloses compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such as Spinocerebellar Ataxia 3 (SCA3 or Machado-Joseph Disease).
    Type: Application
    Filed: January 18, 2024
    Publication date: July 30, 2026
    Inventors: Hasane RATNI, Ingo KONETZKI, Brian LUCAS, Michael LUZZIO
  • Methods and compositions for modulating splicing
    Patent number: 12612397
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of the small molecule splicing modulator compounds for modulating splicing and treating disease and conditions. In one aspect, disclosed herein are small molecule splicing modulators having a structure of Formula (II), or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 28, 2026
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Brian Lucas, Daniel Brian Horne
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260027118
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: May 12, 2023
    Publication date: January 29, 2026
    Inventors: Brian Lucas, Tiansheng Wang, Hasane Ratni, Sivaraman Dandapani, Ingo Konetzki, Michael Luzzio
  • Methods and compositions for modulating splicing
    Patent number: 12522597
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: January 13, 2026
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Brian Lucas
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20260001889
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: May 12, 2023
    Publication date: January 1, 2026
    Inventors: Brian Lucas, Tiansheng Wang, Hasane Ratni, Sivaraman Dandapani, Ingo Konetzki, Michael Luzzio
  • Methods and compositions for modulating splicing
    Patent number: 12509460
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: December 30, 2025
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Brian Lucas
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250340570
    Abstract: Described herein are compounds of formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such a disease being, for example, Spinocerebellar Ataxia 3.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 6, 2025
    Inventors: Michael Luzzio, Brian Lucas, Sivaraman Dandapani, Hasane Ratni
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250340572
    Abstract: Described herein are compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes, such a disease being, e.g. Spinocerebellar Ataxia 3.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 6, 2025
    Inventors: Michael Luzzio, Brian Lucas, Ingo Konetzki
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250340571
    Abstract: Described herein are compounds of Formula (I) that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 6, 2025
    Inventors: Michael Luzzio, Brian Lucas, Ingo Konetzki
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250340564
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: November 4, 2022
    Publication date: November 6, 2025
    Inventors: Brian LUCAS, Michael LUZZIO, Hasane RATNI
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250304593
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: May 12, 2023
    Publication date: October 2, 2025
    Inventors: Brian Lucas, Tiansheng Wang, Hasane Ratni, Sivaraman Dandapani, Ingo Konetzki, Michael Luzzio
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250127789
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: November 4, 2022
    Publication date: April 24, 2025
    Inventors: Brian LUCAS, Michael LUZZIO, Sivaraman DANDAPANI, Hasane RATNI
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250129090
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: November 4, 2022
    Publication date: April 24, 2025
    Inventors: Brian LUCAS, Michael LUZZIO, Sivaraman DANDAPANI, Hasane RATNI
  • COMPOSITIONS USEFUL FOR MODULATING SPLICING
    Publication number: 20250101034
    Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: November 4, 2022
    Publication date: March 27, 2025
    Inventors: Brian LUCAS, Hasane RATNI, Ingo KONETZKI, Michael LUZZIO
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20250101016
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: February 27, 2024
    Publication date: March 27, 2025
    Inventors: Michael LUZZIO, Brian LUCAS, Tiansheng WANG, Jun FENG
  • Methods and compositions for modulating splicing
    Patent number: 11964971
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 23, 2024
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Brian Lucas, Tiansheng Wang, Jun Feng
  • Methods and compositions for modulating splicing
    Patent number: 11845744
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: December 19, 2023
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Brian Lucas, Daniel Brian Horne, Tiansheng Wang