Patents by Inventor Michael Luzzio

Michael Luzzio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11326165
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: May 10, 2022
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Publication number: 20220098168
    Abstract: Provided herein are structure-based screening platforms and methods to identify small molecules that can bind polynucleotides and/or complexes formed by polynucleotides and proteins. Structure-based screening platforms and methods to characterize interactions of small molecules with polynucleotides and/or with complexes formed by polynucleotides and proteins are also provided herein. Methods and compositions to identify small molecules that can bind polynucleotides and/or polynucleotide-protein complexes involved in RNA splicing are also provided herein.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Inventors: KATHLEEN MCCARTHY, Michael Luzzio
  • Publication number: 20220048902
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 17, 2022
    Inventors: Michael LUZZIO, Brian LUCAS, Daniel Brian HORNE
  • Publication number: 20220048890
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 17, 2022
    Inventors: MICHAEL LUZZIO, Brian LUCAS
  • Publication number: 20220041599
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 10, 2022
    Inventors: MICHAEL LUZZIO, BRIAN LUCAS
  • Publication number: 20220024895
    Abstract: Provided herein are structure-based screening platforms and methods to identify small molecules that can bind polynucleotides and/or complexes formed by polynucleotides and proteins. Structure-based screening platforms and methods to characterize interactions of small molecules with polynucleotides and/or with complexes formed by polynucleotides and proteins are also provided herein. Methods and compositions to identify small molecules that can bind polynucleotides and/or polynucleotide-protein complexes involved in RNA splicing are also provided herein.
    Type: Application
    Filed: October 15, 2021
    Publication date: January 27, 2022
    Inventors: KATHLEEN MCCARTHY, MICHAEL LUZZIO
  • Patent number: 11162101
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: November 2, 2021
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Patent number: 11129829
    Abstract: Described herein are methods of use of small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 28, 2021
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, Botao Liu
  • Publication number: 20210292316
    Abstract: Described herein are splice modifying compounds affecting splicing of mRNA, such as pre-mRNA, expressed from the FOXM1 gene, compositions comprising thereof, and methods using the same.
    Type: Application
    Filed: April 10, 2019
    Publication date: September 23, 2021
    Inventors: Michael LUZZIO, Kathleen MCCARTHY
  • Patent number: 11091475
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: August 17, 2021
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Publication number: 20210171519
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: March 13, 2020
    Publication date: June 10, 2021
    Inventors: Michael Luzzio, Kathleen MCCARTHY, William HANEY
  • Patent number: 11021708
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: June 1, 2021
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Patent number: 11008572
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: May 18, 2021
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Publication number: 20200390765
    Abstract: Described herein are methods of use of small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: March 9, 2020
    Publication date: December 17, 2020
    Inventors: Michael Luzzio, Kathleen McCarthy, Botao Liu
  • Publication number: 20200277289
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: February 4, 2020
    Publication date: September 3, 2020
    Inventors: Michael LUZZIO, Kathleen MCCARTHY, William HANEY
  • Publication number: 20200247799
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Michael LUZZIO, Kathleen MCCARTHY, William HANEY
  • Publication number: 20200224199
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 16, 2020
    Inventors: Michael Luzzio, Kathleen Mccarthy, William Haney
  • Publication number: 20080234303
    Abstract: The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, salt thereof, wherein R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: December 20, 2006
    Publication date: September 25, 2008
    Inventors: Samit Bhattacharya, Michael Luzzio, Donn Wishka, Gonghua Pan, Arthur Brosius, Joel Arcari, James Southers, Kendra Nelson, Jun Xiao
  • Publication number: 20080051419
    Abstract: The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is a moiety of formula: and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, D, E, V, W, Y, R1, R2, R5, R6, L, and u are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I to a patient in need thereof, and to compositions for treating such disorders which contain the compounds of formula I. The invention also relates to methods of making the compounds of formula I.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 28, 2008
    Inventors: Matthew Corbett, Kevin Freeman-Cook, Goss Kauffman, Blaise Lippa, Michael Luzzio, Joel Morris
  • Publication number: 20060281774
    Abstract: The present invention relates to a compound of the formula 1 wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: August 17, 2006
    Publication date: December 14, 2006
    Inventors: John Kath, Michael Luzzio