Patents by Inventor Michael Luzzio

Michael Luzzio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating splicing
    Patent number: 11964971
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 23, 2024
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Brian Lucas, Tiansheng Wang, Jun Feng
  • Methods and compositions for modulating splicing
    Patent number: 11845744
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: December 19, 2023
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Brian Lucas, Daniel Brian Horne, Tiansheng Wang
  • COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230331718
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: January 31, 2023
    Publication date: October 19, 2023
    Inventors: Michael Luzzio, Brian Lucas, Tiansheng Wang
  • COMPOSITIONS AND METHODS FOR CORRECTION OF ABERRANT SPLICING
    Publication number: 20230227474
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 20, 2023
    Applicant: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Brian Lucas
  • METHODS AND COMPOSITIONS FOR SCREENING AND IDENTIFICATION OF SPLICING
    Publication number: 20230152257
    Abstract: Provided herein are structure-based screening platforms and methods to identify small molecules that can bind polynucleotides and/or complexes formed by polynucleotides and proteins. Structure-based screening platforms and methods to characterize interactions of small molecules with polynucleotides and/or with complexes formed by polynucleotides and proteins are also provided herein. Methods and compositions to identify small molecules that can bind polynucleotides and/or polynucleotide-protein complexes involved in RNA splicing are also provided herein.
    Type: Application
    Filed: September 25, 2018
    Publication date: May 18, 2023
    Inventors: Kathleen MCCARTHY, Michael LUZZIO
  • Methods and compositions for modulating splicing
    Patent number: 11603531
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: March 14, 2023
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230069804
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: August 2, 2021
    Publication date: March 2, 2023
    Inventors: Michael Luzzio, Brian Lucas, Tiansheng Wang
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230068499
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 29, 2021
    Publication date: March 2, 2023
    Inventors: MICHAEL LUZZIO, BRIAN LUCAS, TIANSHENG WANG, JUN FENG
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230067064
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: August 2, 2021
    Publication date: March 2, 2023
    Inventors: Michael Luzzio, Brian Lucas
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230059865
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: October 15, 2021
    Publication date: February 23, 2023
    Inventors: MICHAEL LUZZIO, Kathleen MCCARTHY, William HANEY
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230054781
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 23, 2023
    Inventors: Michael LUZZIO, Brian LUCAS
  • METHODS FOR MODULATING SPLICING
    Publication number: 20230025130
    Abstract: Described herein are methods of use of small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 26, 2023
    Inventors: Michael Luzzio, Kathleen McCarthy, Botao Liu
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230027684
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: August 2, 2021
    Publication date: January 26, 2023
    Inventors: Michael LUZZIO, Brian LUCAS, Daniel Brian HORNE
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230020922
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: August 2, 2021
    Publication date: January 19, 2023
    Inventors: Michael LUZZIO, Brian LUCAS
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230009712
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 12, 2023
    Inventors: Michael Luzzio, Brian Lucas, Daniel Brian Home, Tiansheng Wang
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20230008867
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: August 2, 2021
    Publication date: January 12, 2023
    Inventors: Michael LUZZIO, Brian LUCAS, Daniel Brian HORNE, Tiansheng WANG
  • METHODS AND COMPOSITIONS FOR MODULATING SPLICING
    Publication number: 20220403383
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Application
    Filed: April 12, 2021
    Publication date: December 22, 2022
    Inventors: Michael LUZZIO, Kathleen MCCARTHY, William HANEY
  • Compounds for the treatment of cancer
    Patent number: 11530207
    Abstract: Described herein are splice modifying compounds affecting splicing of mRNA, such as pre-mRNA, expressed from the FOXM1 gene, compositions comprising thereof, and methods using the same.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 20, 2022
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy
  • Methods and compositions for modulating splicing
    Patent number: 11434489
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: September 6, 2022
    Assignee: Skyhawk Therapeutics, Inc.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Methods and compositions for modulating splicing
    Patent number: 11326165
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: May 10, 2022
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney