Patents by Inventor Michael M. Becker
Michael M. Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240144286Abstract: Techniques for patient medical care are disclosed. These techniques include identifying a plurality of rules relating to a purchase of a medical item. The techniques further include selecting a first rule, of the plurality of rules, to apply to the purchase, including generating a specificity score for each of the plurality of rules, based on setting one or more bit values in each specificity score using matching criteria between the respective rule and the purchase and comparing the specificity scores for the plurality of rules. The techniques further include facilitating supply of the medical item to a patient based on completing the purchase using the selected first rule.Type: ApplicationFiled: October 26, 2023Publication date: May 2, 2024Inventors: Jennifer A. KEISER VOAS, Michael K. MILLER, Howard Ashley PIERCE-MORGAN, Dean BENNETT, Sam MAKONNEN, Stuart HOOD, Kim M. BECKER, Graham Macgregor PATERSON, Robert M. WRIGHT
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Patent number: 11035012Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.Type: GrantFiled: February 23, 2018Date of Patent: June 15, 2021Assignee: GEN-PROBE INCORPORATEDInventors: Reinhold Pollner, Mehrdad Majlessi, Susan Yamagata, Michael M. Becker, Mark Reynolds, Lyle Arnold
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Publication number: 20210102201Abstract: Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically to an immobilized probe via a specific binding pair that has one member on the capture probe and one member on the immobilized probe are disclosed. Compositions that include a capture probe that binds nonspecifically to a target nucleic acid and specifically to an immobilized probe via binding of members of a specific binding pair in a solution phase of a reaction mixture are disclosed.Type: ApplicationFiled: December 18, 2020Publication date: April 8, 2021Inventors: Michael M. Becker, Mehrdad R. Majlessi
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Publication number: 20210024982Abstract: The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target and/or contaminating nucleic acids. Target nucleic acids that have been selectively hybridized and captured using the current invention are then used in subsequent analysis, wherein the presence of non-target and/or contaminating nucleic acids that interfere with said subsequent analysis have been substantially reduced or eliminated, thereby providing improved analysis results.Type: ApplicationFiled: October 1, 2020Publication date: January 28, 2021Applicant: GEN-PROBE INCORPORATEDInventors: Michael M. BECKER, Kristin W. LIVEZEY, Wai-Chung LAM
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Patent number: 10900033Abstract: Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically to an immobilized probe via a specific binding pair that has one member on the capture probe and one member on the immobilized probe are disclosed. Compositions that include a capture probe that binds nonspecifically to a target nucleic acid and specifically to an immobilized probe via binding of members of a specific binding pair in a solution phase of a reaction mixture are disclosed.Type: GrantFiled: January 7, 2016Date of Patent: January 26, 2021Assignee: Gen-Probe IncorporatedInventors: Michael M. Becker, Mehrdad R. Majlessi
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Patent number: 10829801Abstract: The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target and/or contaminating nucleic acids. Target nucleic acids that have been selectively hybridized and captured using the current invention are then used in subsequent analysis, wherein the presence of non-target and/or contaminating nucleic acids that interfere with said subsequent analysis have been substantially reduced or eliminated, thereby providing improved analysis results.Type: GrantFiled: September 18, 2017Date of Patent: November 10, 2020Assignee: GEN-PROBE INCORPORATEDInventors: Michael M. Becker, Kristin W. Livezey, Wai-Chung Lam
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Patent number: 10724085Abstract: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products.Type: GrantFiled: February 22, 2018Date of Patent: July 28, 2020Inventors: Steven T. Brentano, Dmitry Lyakhov, Norman C. Nelson, James D. Carlson, Michael M. Becker, Lyle J. Arnold, Jr.
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Patent number: 10689712Abstract: Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares.Type: GrantFiled: September 8, 2017Date of Patent: June 23, 2020Assignee: GEN-PROBE INCORPORATEDInventors: Shannon K. Kaplan, Kristin W. Livezey, Michael M. Becker, James J. Hogan
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Patent number: 10415092Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: GrantFiled: January 27, 2017Date of Patent: September 17, 2019Assignee: GEN-PROBE INCORPORATEDInventors: Steven T. Brentano, Dmitry Lyakhov, James D. Carlson, Norman C. Nelson, Lyle J. Arnold, Michael M. Becker
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Patent number: 10407723Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: GrantFiled: May 15, 2017Date of Patent: September 10, 2019Assignee: GEN-PROBE INCORPORATEDInventors: Steven T. Brentano, Dmitry Lyakhov, James D. Carlson, Norman C. Nelson, Lyle J. Arnold, Michael M. Becker
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Patent number: 10316352Abstract: The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target and/or contaminating nucleic acids. Target nucleic acids that have been selectively hybridized and captured using the current invention are then used in subsequent analysis, wherein the presence of non-target and/or contaminating nucleic acids that interfere with said subsequent analysis have been substantially reduced or eliminated, thereby providing improved analysis results.Type: GrantFiled: May 13, 2009Date of Patent: June 11, 2019Assignee: GEN-PROBE INCORPORATEDInventors: Michael M. Becker, Kristin W. Livezey, Wai-Chung Lam
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Publication number: 20190024158Abstract: The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results.Type: ApplicationFiled: March 14, 2016Publication date: January 24, 2019Inventors: Michael M. BECKER, Kristin W. LIVEZEY, Wai-Chung LAM
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Patent number: 10167500Abstract: The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results.Type: GrantFiled: March 14, 2016Date of Patent: January 1, 2019Assignee: GEN-PROBE INCORPORATEDInventors: Michael M. Becker, Kristin W. Livezey, Wai-Chung Lam
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Patent number: 10119163Abstract: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products.Type: GrantFiled: March 2, 2016Date of Patent: November 6, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Steven T. Brentano, Dmitry Lyakhov, Norman C. Nelson, James D. Carlson, Michael M. Becker, Lyle J. Arnold, Jr.
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Publication number: 20180251862Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.Type: ApplicationFiled: February 23, 2018Publication date: September 6, 2018Inventors: Reinhold Pollner, Mehrdad Majlessi, Susan Yamagata, Michael M. Becker, Mark Reynolds, Lyle Arnold
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Publication number: 20180208981Abstract: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products.Type: ApplicationFiled: February 22, 2018Publication date: July 26, 2018Inventors: Steven T. BRENTANO, Dmitry LYAKHOV, Norman C. NELSON, James D. CARLSON, Michael M. BECKER, Lyle J. ARNOLD, JR.
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Patent number: 9970766Abstract: One embodiment includes an artificial vision system mounted on a platform. The system includes an image system comprising a video source that is configured to capture a plurality of sequential images. The image system also includes an image processing system configured, via at least one processor, to process the plurality of sequential images to calculate situational awareness (SA) data with respect to each of the plurality of sequential images and to convert the processed plurality of sequential images to visible images. The system further includes a video display system configured to display the visible images associated with the processed plurality of sequential images and to visibly identify the SA data relative to the platform.Type: GrantFiled: September 30, 2013Date of Patent: May 15, 2018Assignee: Northrop Grumman Systems CorporationInventors: Dustin D. Baumgartner, Bruce J. Schachter, Kathryn B. Stewart, Michael M. Becker
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Patent number: 9938590Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.Type: GrantFiled: September 16, 2011Date of Patent: April 10, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Reinhold Pollner, Mehrdad Majlessi, Susan Yamagata, Michael M. Becker, Mark Reynolds, Lyle Arnold
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Patent number: 9920382Abstract: Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares.Type: GrantFiled: November 11, 2015Date of Patent: March 20, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Shannon K. Kaplan, Kristin W. Livezey, Michael M. Becker, James J. Hogan
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Patent number: RE48909Abstract: The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results.Type: GrantFiled: April 29, 2019Date of Patent: February 1, 2022Assignee: GEN-PROBE INCORPORATEDInventors: Michael M. Becker, Kristin W. Livezey, Wai-Chung Lam