Patents by Inventor Michael M. Harpold

Michael M. Harpold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human calcium channel compositions and methods
    Patent number: 7414110
    Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: August 19, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human neuronal nicotinic acetylcholine receptor ?and ?
    Patent number: 7169895
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically ?6) and beta subunits (specifically ?3) are provided. In addition, combinations of a plurality of subunits (i.e., one or more of ?1, ?2, ?3, ?4, ?5, ?6 and/or ?7 subunits in combination with one or more of ?3 subunits are provided.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: January 30, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 7119067
    Abstract: Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding ?6 subunits and molecules encoding ?3 subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of ?1, ?2, ?3, ?4, ?5, ?6 and/or ?7 subunits in combination with one or more of ?3 subunits or such as one or more of ?2, ?3 and/or ?4 subunits in combination with an ?6 subunit are provided.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: October 10, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Nucleic acids encoding human calcium channel and methods of use thereof
    Patent number: 7063950
    Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: June 20, 2006
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams
  • Human calcium channel compositions and methods
    Publication number: 20040018510
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Application
    Filed: February 27, 2003
    Publication date: January 29, 2004
    Applicant: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Publication number: 20040002122
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically &agr;6) and beta subunits (specifically &bgr;3) are provided. In addition, combinations of a plurality of subunits (i.e., one or more of &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits are provided.
    Type: Application
    Filed: November 25, 2002
    Publication date: January 1, 2004
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor & subunit methods employing same
    Patent number: 6664375
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: December 16, 2003
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human calcium channel compositions and methods
    Patent number: 6653097
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Publication number: 20030138911
    Abstract: Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding &agr;6 subunits and molecules encoding &bgr;3 subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits or such as one or more of &bgr;2, &bgr;3 and/or &bgr;4 subunits in combination with an &agr;6 subunit are provided.
    Type: Application
    Filed: January 23, 2003
    Publication date: July 24, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Calcium channel compositions and methods
    Patent number: 6528630
    Abstract: Isolated nucleic acid encoding calcium channel &agr;1F-subunits, including subunits encoded by nucleic acid that arises as splice variants of primary transcripts, is provided. Cells and vectors containing the nucleic acid and methods for identifying compounds that modulate the activity of calcium channels that contain &agr;1F-subunits are also provided.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: March 4, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Williams, Kenneth A. Stauderman, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 6524789
    Abstract: Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding &agr;6 subunits and molecules encoding &bgr;3 subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits or such as one or more of &bgr;2, &bgr;3 and/or &bgr;4 subunits in combination with an &agr;6 subunit are provided.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: February 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor &agr;6 and &bgr;3 nucleic acid
    Patent number: 6485967
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically &agr;6) and beta subunits (specifically &bgr;3) are provided. In addition, combinations of a plurality of subunits (i.e., one or more of as &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Michael M. Harpold
  • Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
    Patent number: 6440681
    Abstract: Methods for identifying compounds which modulate the activity of human neuronal nicotinic acetylcholine receptors are provided. Invention methods employ DNAs encoding alpha and beta subunits of human neuronal nicotinic acetylcholine receptors, and the polypeptides encoded thereby. Test cells useful for conducting invention assays include mammalian and amphibian cells containing said DNA. Various combinations of subunits (i.e., one or more &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and &agr;7 subunits in combination with &bgr;2, &bgr;3 and/or &bgr;4 subunits) can be employed for the invention assays.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 27, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Publication number: 20020111463
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
    Type: Application
    Filed: June 27, 2001
    Publication date: August 15, 2002
    Applicant: MERCK & CO., INC.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human calcium channel compositions and methods
    Patent number: 6387696
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 14, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 6303753
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 16, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human calcium channel compositions and methods
    Patent number: 6096514
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 1, 2000
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Recombinant human calcium channel .beta..sub.4 subunits
    Patent number: 6090623
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the .alpha..sub.1A-1, .alpha..sub.1A-2, .alpha..sub.1E-1, .alpha..sub.1C-2, .alpha..sub.1E-3, .beta..sub.3-1, .beta..sub.2C, .beta..sub.2D, .beta..sub.2E and .beta..sub.4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: July 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • DNA and mRNA encoding an .alpha..sub.4 subunit of human neuronal nicotinic acetylcholine receptor and cells transformed with same
    Patent number: 6022704
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 8, 2000
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 5910582
    Abstract: Nucleic acid encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: June 8, 1999
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold