Abstract: A portable electronic device may include a housing having a wall defining an opening in the housing and at least a portion of four side surfaces of the portable electronic device. The portable electronic device may further include a display at least partially within the housing, a front cover positioned in the opening in the housing and over the display, the front cover defining a front surface, a peripheral side surface extending from the front surface and at least partially surrounded by the wall of the housing, and a notch that, together with a portion of the wall of the housing, defines an acoustic port of the portable electronic device. The electronic device may further include an acoustic port cover positioned at least partially in the acoustic port and a speaker at least partially within the housing and configured to direct sound through the acoustic port cover.

Abstract: A system and related methods thereof involving self-administration of an agent to an animal. In certain embodiments, the system comprises an enclosure for the confinement of an animal; a sensor that produces a signal when purposefully activated by the animal in said enclosure, wherein the purposefully activation defines a first behavior of the animal that is located at a first behavior location; and an agent dispenser that is configured to provide the agent in the enclosure in response to the sensor being purposefully activated, wherein the agent is provided remotely from the first behavior location so as to require the animal to travel to the remotely provided agent at a remote provision location, wherein the traveling defines a second behavior of the animal. The system and related methods thereof can be used to provide a model system to evaluate the behavioral and/or physiological response(s) to a self-administered agent.

Abstract: Serotonin neurons modulate most homeostatic Central Nervous System (CNS) functions while influencing the expression of behavioral traits such as mood, aggression and anxiety. Serotonin neuron dysfunction has been implicated in depression, addiction, autism and sudden infant death syndrome. This disclosure describes a straightforward, highly reproducible method for genetically accessing serotonin neurons and a sub-population of intestinal enterocytes, in vivo, using BAC-based transgenes that can be constructed using simple subcloning procedures. Compositions described herein include these transgenes and methods for making and using them to create transgenic mouse strains and identify serotonin and intestinal enterocytes without immunostaining.

Abstract: Serotonin neurons modulate most homeostatic Central Nervous System (CNS) functions while influencing the expression of behavioral traits such as mood, aggression and anxiety. Serotonin neuron dysfunction has been implicated in depression, addiction, autism and sudden infant death syndrome. This disclosure describes a straightforward, highly reproducible method for genetically accessing serotonin neurons and a sub-population of intestinal enterocytes, in vivo, using BAC-based transgenes that can be constructed using simple subcloning procedures. Compositions described herein include these transgenes and methods for making and using them to create transgenic mouse strains and identify serotonin and intestinal enterocytes without immunostaining.

Abstract: Apparatus for remote programming of an electronic device such as a video cassette recorder. A hand held portable programming unit stores intructions for the device as those instructions are entered through a key pad. These instructions are encoded into a form suitable for telecommunications to the device. A receiver unit which interfaces with the electric device receives the instructions and converts them into a form suitable for programming the device. When used in programming a video cassette recorder the instructions include the channel to be taped and the time and date the taping is to take place.