Abstract: The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.

Abstract: The invention discloses a methodology for the culture of bladder cell lines and organoids from human bladder, both non-cancerous as well as cancer tissue.

Abstract: The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.

Abstract: A 3-gene prognostic panel has been identified that together accurately predicted the outcome of low Gleason score prostate tumors as either truly indolent or at a high risk of becoming aggressive. The 3-gene prognostic panel was validated on independent cohorts confirmed its independent prognostic value, as well as its ability to improve prognosis with currently used clinical nomograms. Expression of the 3-gene prognostic panel was determined by quantifying mRNA or protein encoded by the panel (collectively referred to as “prognostic biomarkers”). The prognostic biomarkers were discovered to be up-regulated in indolent tumors and down-regulated in aggressive forms of prostate cancer.

Abstract: The present invention encompasses methods for reprogramming fibroblast cells in culture, which are able to generate generic epithelial cells therefrom.

Abstract: The present invention is directed to an isolated population of luminal stem cells obtained from the prostate epithelium that express Nkx3.1. The invention is also directed to methods for diagnosing whether a patient is at risk of developing prostate cancer.

Abstract: A handheld electronic apparatus. The handheld electronic apparatus includes a first connecting member, a second connecting member, an operating member, a first holding member and a second holding member. The second connecting member is rotatably connected to the first connecting member. The operating member is rotatably connected to the second connecting member. The first holding member is rotatably connected to the first connecting member. The second holding member is rotatably connected to the first connecting member. The first and second holding members relatively rotate between a closed position and an open position. The invention thereby provides convenient use of communication, digital photography, PDA, and video game functions in a single device.

Abstract: The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a) contacting a biopsy tissue sample with a monoclonal antibody, or a fragment thereof, having an antigen-binding specific region for NKX3.1, under conditions permitting immunospecific binding between the monoclonal antibody, or a fragment thereof, and NKX3.1 in the sample; and (b) detecting whether immunospecific binding has occurred to detect the presence of NKX3.1 in the sample.

Abstract: The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a) contacting a biopsy tissue sample with a monoclonal antibody, or a fragment thereof, having an antigen-binding specific region for NKX3.1, under conditions permitting immunospecific binding between the monoclonal antibody, or a fragment thereof, and NKX3.1 in the sample; and (b) detecting whether immunospecific binding has occurred to detect the presence of NKX3.1 in the sample.

Abstract: The present invention pertains to a mutant mouse comprising a Nkx3.1 gene having a disruption in at least one exon. The disruption has been introduced into the genome of the mouse by homologous recombination in an embryonic stem cell. The disruption provides a null mutation which results in no expression of Nkx3.1 by the mouse and in defects in prostate ductal morphogenesis and secretory protein production in the mouse. The mouse displays prostatic epithelial hyperplasia and dysplasia. The present invention pertains to a method for screening for a drug, or other therapeutic intervention, useful for preventing or treating prostate cancer. The method comprises administering a drug, or other therapeutic intervention, to a mutant mouse predisposed towards prostate cancer; diagnosing the mutant mouse for prostate a cancer precursor; and comparing the mutant mouse with a control mutant mouse not treated with the drug, or other therapeutic intervention.

Abstract: A container/bulk cargo interchangeable system to allow a cargo ship's hold the versatility and option of storing and carrying either ISO containers entirely, or of storing and carrying bulk cargo or break bulk entirely, or of storing and carrying a combination of ISO containers and bulk cargo or break bulk. Sets of two flat platforms may be raised to their vertical upright positions to permit the entire storage of ISO containers; or the sets of flat platforms may be lowered to their horizontal dispositions for the entire storage thereon of bulk cargo or break bulk; or the requisite number of sets of flat platforms may be raised to their vertical upright positions and the remaining sets of flat platforms may be lowered to their horizontal dispositions for storage of ISO containers and bulk cargo or break bulk, respectively.