Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: Apparatus for mixing two or more gases prior to entering a reaction chamber, reactor systems including the apparatus, and methods of using the apparatus and systems are disclosed. The systems and methods as described herein can be used to, for example, pulse a mixture of two or more precursors to a reaction chamber.

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

Abstract: Systems and methods determine alignment between a wire and a laser beam in laser joining. A system for checking alignment of a wire relative to a beam of a laser includes a controller configured to align, by tooling, the beam with a sensor system. A laser generates the beam across the wire, with the beam directed to the sensor system. The sensor system measures light intensity of the beam. A processor computes a feature parameter representative of an alignment between the wire and the beam. The processor determines whether the feature parameter is within the process specifications.

Abstract: Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.

Abstract: One embodiment provides an apparatus comprising a memory stack including multiple memory dies and a parallel processor including a plurality of multiprocessors. Each multiprocessor has a single instruction, multiple thread (SIMT) architecture, the parallel processor coupled to the memory stack via one or more memory interfaces. At least one multiprocessor comprises a multiply-accumulate circuit to perform multiply-accumulate operations on matrix data in a stage of a neural network implementation to produce a result matrix comprising a plurality of matrix data elements at a first precision, precision tracking logic to evaluate metrics associated with the matrix data elements and indicate if an optimization is to be performed for representing data at a second stage of the neural network implementation, and a numerical transform unit to dynamically perform a numerical transform operation on the matrix data elements based on the indication to produce transformed matrix data elements at a second precision.

Abstract: New and/or improved coatings, layers or treatments for porous substrates, including battery separators or separator membranes, and/or coated or treated porous substrates, including coated battery separators, and/or batteries or cells including such coatings or coated separators, and/or related methods including methods of manufacture and/or of use thereof are disclosed. Also, new or improved coatings for porous substrates, including battery separators, which comprise at least a matrix material or a polymeric binder, and heat-resistant particles with additional additives, materials or components, and/or to new or improved coated or treated porous substrates, including battery separators, where the coating comprises at least a matrix material or a polymeric binder, and heat-resistant particles with additional additives, materials or components are disclosed.

Abstract: A compound is disclosed that has a metal coordination complex structure having at least two ligands coordinated to the metal; wherein the compound has a first substituent R1 at one of the ligands' periphery; wherein a first distance is defined as the distance between the metal and one of the atoms in R1 where that atom is the farthest away from the metal among the atoms in R1; wherein the first distance is also longer than any other atom-to-metal distance between the metal and any other atoms in the compound; and wherein when a sphere having a radius r is defined whose center is at the metal and the radius r is the smallest radius that will allow the sphere to enclose all atoms in the compound that are not part of R1, the first distance is longer than the radius r by at least 2.9 ?.

Abstract: Female fiber optic connectors having a weatherproofing collar disposed rearward of a connection port opening that receives a fiber optic plug along with cable assemblies comprising the female fiber optic connector and with methods of making the same. The female fiber optic connectors comprise an actuator such as a rocker latch arm or the like disposed under the weatherproofing collar used for releasing or securing an external fiber optic plug that may be received in the connection port. The weatherproofing collar protects the actuator such as the rocker arm latch and surrounding area from dirt, debris, moisture and the like from ingress into the connector. One or more end caps may be used with the weatherproofing collar. The weatherproofing collar allows for a ruggedized fiber optic connector having a quick connect and release mechanism for the external fiber optic plug connector mated to the female fiber optic connector.

Abstract: Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.

Abstract: An apparatus to facilitate optimization of a convolutional neural network (CNN) is disclosed. The apparatus includes optimization logic to receive a CNN model having a list of instructions and including pruning logic to optimize the list of instructions by eliminating branches in the list of instructions that comprise a weight value of 0.

Abstract: An apparatus to facilitate workload scheduling is disclosed. The apparatus includes one or more clients, one or more processing units to processes workloads received from the one or more clients, including hardware resources and scheduling logic to schedule direct access of the hardware resources to the one or more clients to process the workloads.

Abstract: A power inverter assembly including first and second power inverter units configured to receive power from at least one energy source, and a portable structural platform to support the units. The units each have a terminals for connection to an electric power system, a solar panel arrangement, and a DC energy storage subsystem. The units are coupled to the platform. The first unit has a first pre-set AC power rating having a first maximum AC power output value for output to the power system and the second unit has a second pre-set AC power rating having a second maximum AC power output value for output to the power system to provide the assembly with a total maximum power output rating based on a combined total of the first and second pre-set AC power ratings. The energy source can include the power system, the solar panel arrangement, and the storage subsystem.

Abstract: An optical ferrule assembly includes a hybrid optical ferrule having a glass portion assembled to a polymeric portion. The polymeric portion includes a groove for receiving and supporting an optical fiber having opposing open front and back ends. A light redirecting member includes an input surface for receiving light from the optical fiber and a light redirecting side. The open back end of the groove and the input surface define a recessed region therebetween. The glass portion includes an optically transparent glass insert disposed in the recessed region conforming in shape to an internal shape of the recessed region. An optical fiber is received and supported in the groove. The optical fiber includes a fiber end laser welded to the glass insert so that a central light ray from the optical fiber propagates through the glass insert before being received and redirected by the light redirecting side.

Abstract: Devices are provided for mechanically induced ventricular growth in a single ventricle patient that include a body comprising a plurality of springs coupled together to define an open upper end and a closed lower end, wherein the springs surround an interior region of the body sized to receive a portion of a patient's heart. The device may be secured over a portion of a patient's heart, e.g., overlying the left ventricular region, and the bias of the springs may apply strain to the myocardium of the heart to induce ventricular chamber growth.

Abstract: Methods and systems to validated physiologic waveform reliability and uses thereof are provided. A number of embodiments describe methods to validate waveform reliability, including blood pressure waveforms, electrocardiographic waveforms, and/or any other physiological measurement producing a continuous waveform. Certain embodiments output reliability measurements to closed loop systems that can control infusion rates of cardioactive drugs or other fluids in order to regulate blood pressure, cardiac rate, cardiac contractility, and/or vasomotor tone. Further embodiments allow for waveform evaluators to validate waveform reliability based on at least one waveform feature using data collected from clinical monitors using machine learning algorithms.

Abstract: Disclosed are embodiments of a video display input assembly including a mechanical rotatable bezel surrounding the video display. The video display input assembly is suitable for use in a gaming terminal, a gaming cabinet or a gaming machine, including as a retrofit to an pre-existing gaming machine. Direction and speed of a manual rotation of the bezel is detected and interpreted. The result may be used to control various aspects of operation of the gaming terminal, gaming cabinet or gaming machine, including providing input for game play. The video display may be updated in real-time to reflect the rotation of the bezel. A motor may be coupled to the rotatable bezel to provide resistance, assistance or operator feedback.

Abstract: A trailer for use with a towing vehicle having a first connector. The trailer includes a connector assembly, a plurality of wheels, and a trailer assist assembly. The connector assembly includes a second connector and at least one sensor. The second connector is configured to be coupled to the first connector to thereby couple the trailer to the towing vehicle. The at least one sensor is configured to detect forces applied to at least a portion of the connector assembly. The trailer assist assembly includes a control system and at least one electric motor. The control system is configured to control operation of the at least one electric motor, receive sensor signals from the at least one sensor, and use the sensor signals to determine when to operate the at least one electric motor. The at least one electric motor is operable to drive the plurality of wheels.

Abstract: Disclosed are embodiments of a video display input assembly including a mechanical rotatable bezel surrounding the video display. The video display input assembly is suitable for use in a gaming terminal, a gaming cabinet or a gaming machine, including as a retrofit to an pre-existing gaming machine. Direction and speed of a manual rotation of the bezel is detected and interpreted. The result may be used to control various aspects of operation of the gaming terminal, gaming cabinet or gaming machine, including providing input for game play. The video display may be updated in real-time to reflect the rotation of the bezel. A motor may be coupled to the rotatable bezel to provide resistance, assistance or operator feedback.

Abstract: Disclosed are embodiments of a video display input assembly including a mechanical rotatable bezel surrounding the video display. The video display input assembly is suitable for use in a gaming terminal, a gaming cabinet or a gaming machine, including as a retrofit to an pre-existing gaming machine. Direction and speed of a manual rotation of the bezel is detected and interpreted. The result may be used to control various aspects of operation of the gaming terminal, gaming cabinet or gaming machine, including providing input for game play. The video display may be updated in real-time to reflect the rotation of the bezel. A motor may be coupled to the rotatable bezel to provide resistance, assistance or operator feedback.