Patents by Inventor Michael Mackett

Michael Mackett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
    Patent number: 7045313
    Abstract: Methods and compositions are provided for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes. Expression of foreign genes is obtained by combining vaccinia virus transcriptional regulatory sequence with uninterrupted foreign protein coding sequences in vitro to form a chimeric gene. The chimeric gene is flanked by DNA from a non-essential region of the vaccinia virus genome to provide sites for in vivo homologous recombination. These steps are facilitated by the construction of plasmids that contain multiple restriction endonuclease sites, next to the vaccinia transcriptional regulatory sequences, for insertion of any foreign protein coding sequence. Transfection procedures are used to introduce the DNA into cells where homologous recombination results in the insertion of the chimeric gene into a non-essential region of the vaccinia virus genome.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: May 16, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey Smith
  • Methods of immunization using recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 7045136
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 16, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Compositions containing recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 7015024
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses, also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 21, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 6998252
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 14, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Vaccine for vesicular stomatitis virus
    Patent number: 4738846
    Abstract: Synthetic vaccines for both the Indiana and New Jersey serotypes of vesicular stomatitis virus are provided. Recombinant vaccinia viruses are created with DNA sequences which encode antigenically active VSV proteins. Vaccinia virus sequences are inserted in plasmids and DNA sequences corresponding to encoding portions of the VSV genome are inserted into the plasmids with flanking vaccinia virus sequences. In cells transformed with such plasmids and also infected with vaccinia virus, homologous recombination occurs, producing the modified vaccinia viruses which act as vaccines encoding VSV proteins and inducing anti-VSV immune responses in inoculated animals.
    Type: Grant
    Filed: August 30, 1984
    Date of Patent: April 19, 1988
    Assignee: The Salk Institute for Biological Studies
    Inventors: John K. Rose, Bernard Moss, Tilahun Yilma, Michael Mackett