Patents by Inventor Michael Madaio

Michael Madaio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-alpha3(IV)nc1 monoclonal antibodies and animal model for human anti-glomerular basement membrane autoantibody disease
    Publication number: 20050107596
    Abstract: The present invention relates to methods of making a mouse model of human anti-GBM disease, to mice produced by such methods, and to human antibodies and antigen-binding portions thereof that specifically bind to ?3(IV) NC1 collagen. The present invention also relates to compositions comprising the above antibodies or portions thereof and methods of using such compositions for diagnosis, and to nucleic acid molecules encoding the above antibodies or portions thereof. The present invention further relates to methods of isolating compounds/peptides that specifically binds anti-?3(IV) NC1 antibodies, pharmaceutical compositions comprising these compounds/peptides and methods of using such compositions for diagnosis and treatment.
    Type: Application
    Filed: April 23, 2002
    Publication date: May 19, 2005
    Inventors: Michael Madaio, Michael Gallo
  • Immunization with plasmid encoding immunogenic proteins and intracellular targeting sequences
    Patent number: 6248565
    Abstract: Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: June 19, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William V. Williams, Michael Madaio, David B. Weiner
  • Plasmids encoding immunogenic proteins and intracellular targeting sequences
    Patent number: 6228621
    Abstract: Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: May 8, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William V. Williams, Michael Madaio, David B. Weiner